Results 71 to 80 of about 154,417 (308)

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Drug–drug interactions involving antidepressants: focus on desvenlafaxine [PDF]

, 2018
Yvette Low,1 Sajita Setia,2 Graca Lima3 1Department of Pharmacy, National University of Singapore, Singapore; 2Medical Affairs, Pfizer Pte. Ltd., Singapore; 3Global Medical Affairs, Asia-Pacific Region, Pfizer, Hong Kong Abstract: Psychiatric and ...
Lima G, Low Y, Setia S
core  

Antidepressants in adolescence

Australian Prescriber, 2022
In adolescence, antidepressants are second-line treatment options after psychological therapy for anxiety and obsessive compulsive disorder. They may be first- or second-line options for severe cases of major depressive disorder. The response to antidepressant treatment is generally good for anxiety and obsessive compulsive disorder, but is less ...
openaire   +2 more sources

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Antidepressants in pregnancy and breastfeeding [PDF]

, 2007
Copyright © 2007 Australian Prescriber Reproduced with permission from Australian Prescriber The document attached has been archived with permission from the publisher/copyright holder.Maternal depression and anxiety during pregnancy and the early years ...
Anna Sved Williams, Sved-Williams, A.
core   +1 more source

Could antidepressants increase mood and immunity at the same time?

Frontiers in Psychiatry
A review of scientific literature suggests that the use of antidepressants can be broadly extended to address various forms of stress and inflammation as an adjunctive therapy that enhances host resistance.
Francis Lavergne, Therese M. Jay
doaj   +1 more source

The antidepressant debate [PDF]

British Journal of Psychiatry, 2002
There has been an extensive debate recently in the North American medical literature and general press concerning the efficacy of antidepressant drugs. Little of this has reached the European press.
openaire   +2 more sources

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Exercise for depression [PDF]

, 2008
Background Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychotherapy, but some people may prefer alternative approaches such as exercise.
McMurdo, Marion, Greig, Carolyn; id_orcid, Greig, Carolyn A., Marion McMurdo, Morley, Wendy, McMurdo, Marion E.T., Paul Campbell, Mead, Gillian E., Gillian E Mead, Wendy Morley, Lawlor, Debbie A., Debbie A Lawlor, Campbell, Paul, Carolyn A Greig   +13 more
core   +1 more source