Results 41 to 50 of about 391,178 (335)

The reported use and effectiveness of Hypericum (St John’s wort) on affective symptoms in a depression self-help group [PDF]

, 2002
A recent meta-analysis suggested that Hypericum perforatum (St John’s wort) is an effective treatment for mild to moderate depression and may have a superior side-effect profile to some antidepressant drugs.
Baldwin, D.S., Dyson, R., Jenkins, G., Mayers, A.G., Tiernan, A.   +4 more
core   +1 more source

Analgesic Mechanisms of Antidepressants for Neuropathic Pain

International Journal of Molecular Sciences, 2017
Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects ...
H. Obata
semanticscholar   +1 more source

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data [PDF]

, 2017
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear.
Altemus, Margaret, Anderson, Page, Andersson, Erik, Cukor, Judith, Davis, Michael, DCS Anxiety Consortium, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Fernández de la Cruz, Lorena, Finck, Claudia, Frumento, Paolo, Geffken, Gary R., Geller, Daniel, Gerardi, Maryrose, Golfels, Fabian, Goodman, Wayne K., Guastella, Adam J., Gutner, Cassidy, Hendriks, Gert-Jan, Heyman, Isobel, Hofmann, Stefan G., Jovanovic, Tanja, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., Lewin, Adam B., Mataix-Cols, David, McConnell, Harry, McNamara, Joseph P., Monzani, Benedetta, Murphy, Tanya K., Norrholm, Seth, Otto, Michael W., Plag, Jens, Pollack, Mark H., Pérez-Vigil, Ana, Ressler, Kerry J., Rodebaugh, Thomas L., Rosenfield, David, Rothbaum, Barbara O., Rück, Christian, Scheeringa, Michael S., Siewert-Siegmund, Anja, Smits, Jasper A.J., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Thuras, Paul, Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna   +56 more
core   +1 more source

Should antidepressants be used for major depressive disorder?

BMJ evidence-based medicine, 2019
Background Major depressive disorder is estimated by the WHO to affect more than 300 million people globally, making depression the leading cause of disability worldwide. Antidepressants are commonly used to treat depression. Objective The study aimed to
J. Jakobsen, C. Gluud, I. Kirsch
semanticscholar   +1 more source

Is depression a real risk factor for acute myocardial infarction mortality? A retrospective cohort study [PDF]

, 2019
Background: Depression has been associated with a higher risk of cardiovascular events and a higher mortality in patients with one or more comorbidities.
Baldo, V., Baldovin, T., Bertoncello, C., Buja, A., Casale, P., Cocchio, S., Fonzo, M., Furlan, P.   +7 more
core   +1 more source

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

Molecular Psychiatry, 2018
Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown.
Anne Gulbins, F. Schumacher, K. A. Becker, B. Wilker, Matthias Soddemann, F. Boldrin, C. Müller, M. Edwards, Michael Goodman, C. Caldwell, B. Kleuser, J. Kornhuber, I. Szabó, E. Gulbins   +13 more
semanticscholar   +1 more source

Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants’ Efficacy and Harm

Frontiers in Psychiatry, 2017
BackgroundIn current psychiatric practice, antidepressants are widely and with ever-increasing frequency prescribed to patients. However, several scientific biases obfuscate estimates of antidepressants’ efficacy and harm, and these are barely recognized
Michael P. Hengartner
doaj   +1 more source

Molecular mechanisms of rapid-acting antidepressants: New perspectives for developing antidepressants

Pharmacological Research, 2023
Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional antidepressants usually require several weeks of continuous administration to exert clinically significant therapeutic effects, while about two-thirds of the ...
Tao Chen, Ling Cheng, Jingwen Ma, Jiyuan Yuan, Chao Pi, Linjin Xiong, Jinglin Chen, Huiyang Liu, Jia Tang, Yueting Zhong, Xiaomei Zhang, Zerong Liu, Ying Zuo, Hongping Shen, Yumeng Wei, Ling Zhao   +15 more
doaj   +1 more source

Influence of mirtazapine on salivary cortisol in depressed patients [PDF]

, 2003
Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C., Hennig, J., Laakmann, G., Schule, C.   +3 more
core   +1 more source