Results 41 to 50 of about 66,382 (184)
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang +12 more
wiley +1 more source
Treatments for pregestational chronic conditions during pregnancy: emulating a target trial with a treatment decision design [PDF]
arXiv, 2023 As a solution to methodologic challenges inherent to estimating causal effects of exposures in early pregnancy, we suggest emulating a target trial using a treatment decision design, wherein time zero is centered around clinical landmarks where treatment decisions may occur, such as the date of preconception counseling or prenatal care initiation ...
arxiv
Antimicrobial Agents and Chemotherapy, 2020 Echinocandins are a first-line therapy for Candida infections through their ability to inhibit the synthesis of polymer β-(1,3)-d-glucan. However, there has been an emergence of multidrug-resistant fungal species necessitating the development of novel ...
S. Chu +5 more
semanticscholar +1 more source
Pharmacological Treatment of Neuropsychiatric Symptoms in Huntington's Disease: A Systematic Review
Movement Disorders Clinical Practice, Volume 12, Issue 4, Page 418-431, April 2025.ABSTRACT Background Studies focusing on the treatment of neuropsychiatric symptoms (NPS) in Huntington's disease (HD) are scarce and show a wide variation in design, outcome measures and methodological quality. The effectiveness of pharmacological treatment of NPS in HD has not been systematically reviewed so far.
Ruben L. Andriessen +5 more
wiley +1 more source
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
History, background, concepts and current use of comedication and polypharmacy in psychiatry [PDF]
, 2013 Based on a careful literature search a review is presented of the history, background, concepts and current use of comedication and polypharmacy in psychiatry.
Grohmann, R. +5 more
core +1 more source
British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa +13 more
wiley +1 more source
An efficient multiple imputation algorithm for control-based and delta-adjusted pattern mixture models using SAS [PDF]
Statistics in Biopharmaceutical research 2016, 2016 In clinical trials, mixed effects models for repeated measures (MMRM) and pattern mixture models (PMM) are often used to analyze longitudinal continuous outcomes. We describe a simple missing data imputation algorithm for the MMRM that can be easily implemented in standard statistical software packages such as SAS PROC MI.
arxiv +1 more source
Use of second-generation antipsychotic agents for sleep and sedation: a provider survey.
Sleep, 2013 OBJECTIVES Anecdotal evidence suggests that second-generation antipsychotic agents are increasingly used to treat sleep problems. This study sought to quantify the proportion of new prescriptions for second-generation antipsychotic agents started for ...
Eric D A Hermes +2 more
semanticscholar +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.UB exerts antidepressant activity and its modulation of microglia activation and neuroinflammation, balanced M1/M2 polarization via the SIRT1‐FOXO1 axis. ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) and its regulatory role in microglia‐
Cuilan Liu +14 more
wiley +1 more source