Results 41 to 50 of about 4,667 (141)

Strategic use of new generation antidepressants for depression: SUN(^_^)D study protocol [PDF]

, 2011
Background After more than half a century of modern psychopharmacology, with billions of dollars spent on antidepressants annually world-wide, we lack good evidence to guide our everyday decisions in conducting antidepressant treatment of patients with ...
Toshi A Furukawa, Tatsuo Akechi, Shinji Shimodera, Mitsuhiko Yamada, Kazuhira Miki, Norio Watanabe, Masatoshi Inagaki, Naohiro Yonemoto   +7 more
core   +1 more source

Interventions for treating anxiety after stroke [PDF]

, 2017
Background Approximately 20% of stroke patients experience clinically significant levels of anxiety at some point after stroke. Physicians can treat these patients with antidepressants or other anxiety-reducing drugs, or both, or they can provide ...
Ahlsiö, Akerlund, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Ayerbe, Baldwin, Beck, Beck, Beck, Bjelland, Boeijen, Broomfield, Campbell Burton, Campbell Burton, Campbell Burton, Castillo, Chaiyawat, Chan, Craig, DerSimonian, Doogan, Fernandez, Gelder, Golding, Guilan, Guyatt, Hackett, Hackett, Hamilton, Hamilton, Hatano, Hoffmann, House, Hyde, Ihle-Hansen, Immink, Intercollegiate Stroke Working Party, Jorm, Jouzi, Karaiskos, Kerr, Kimura, Kongkasuwan, Kulishova, Langhorne, Lepine, Li, Liu, Mahoney, Maier, Max, Menlove, Mikami, Mok, Montgomery, Morrison, National Institute for Health and Care Excellence, Peng, Riedel-Heller, Rijswijk, Rorsman, Shimoda, Wade, Wang, Ware, Wittchen, Wu, Wu, Xue, Yates, Ye, Zarit, Zhang, Zigmond   +75 more
core   +5 more sources

The Global Landscape of Neuropsychiatric Prescribing Practices of Nurses: A Scoping Review

International Journal of Mental Health Nursing, Volume 34, Issue 4, July 2025.
ABSTRACT Mental healthcare service access in South Africa is currently strained due to, among others, shortages of specialised mental healthcare professionals. The National Strategic Plan for HIV, TB and STIs (2023‐2028) recommends enabling nurses to diagnose, prescribe and dispense neuropsychiatric medication for promoting mental health services.
M. Naidoo, C. J. Filmalter, W. Cordier
wiley   +1 more source

Dual alpha2C/5HT1A receptor agonist allyphenyline induces gastroprotection and inhibits fundic and colonic contractility [PDF]

, 2016
Allyphenyline, a novel α2-adrenoceptor (AR) ligand, has been shown to selectively activate α2C-adrenoceptors (AR) and 5HT1A receptors, but also to behave as a neutral antagonist of α2A-ARs.
A Fletcher, A Robert, AE Knaus, AJ Farre, AM Caballero-Plasencia, C Blandizzi, C Cardinaletti, DB Bylund, E Sangiovanni, EJ Dickson, F Bello Del, F Bello Del, F Gentili, F Ponti De, Fabio Del Bello, GB Glavin, GE Boeckxstaens, GR Davies, H Miwa, J Sallinen, J Tack, J Tack, J Tack, J Tack, J Tack, JD Altman, JF Tack, JJ Meana, JR Docherty, K Fülöp, K Gyires, K Gyires, K Gyires, K Gyires, K Gyires, K Gyires, K Gyires, K Hoshino, K Müllner, K Takeuchi, K Takeuchi, Klára Gyires, KP Makaritsis, L Hein, L Laine, L Oudenhove Van, L Xue, L Xue, L Zhang, László Köles, M Bardou, M Kaji, M Nagata, M Philipp, M Philipp, M Ubaldi, Mahmoud Al-Khrasani, Maria Pigini, N Shujaa, P Janssen, P Malfertheiner, PA Crassous, R Krysiak, RE Link, RM Sullivan, S Kwiecien, S Kwiecien, S Szabo, SA El-Maraghy, SJ Kim, Szabina Sipos, T Kemmerly, T Umezawa, T Yoshikawa, TA Voronina, TK Smith, Viktória E. Tóth, WD Paton, Y Tache, Zoltán S. Zádori, ZS Zádori, Ágnes Fehér   +81 more
core   +1 more source

The Blue Light‐Responsive Lateral Pathway of the Retinohypothalamic Tract Promotes Endocannabinoid‐Driven Modulation of Orexin Neurons

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Blue light stimulation of ipRGCs leads to endocannabinoid‐mediated modulation of orexin neuron activity via the retinohypothalamic network. (1) In the first step, blue light‐induced glutamate release from VGluT1/CB1‐positive input depolarizes the OX‐A neuron (red) in the PFH; (2) This depolarization triggers the biosynthesis and release of 2‐AG (green ...
Nicola Forte, Roberta Imperatore, Brenda Marfella, Alessandro Nicois, Roberta Verde, Letizia Palomba, Vincenzo Di Marzo, Luigia Cristino   +7 more
wiley   +1 more source

The Role of Norepinephrine and Its α-Adrenergic Receptors in the Pathophysiology and Treatment of Major Depressive Disorder and Schizophrenia: A Systematic Review [PDF]

, 2017
Norepinephrine (NE) is recognized as having a key role in the pathophysiology of major depressive disorder (MDD) and schizophrenia, although its distinct actions via α-adrenergic receptors (α-ARs) are not well defined.
Anna Eramo, Keva Gwin, Ruth A. Duffy, Steve J. Offord, Vladimir Maletic   +4 more
core   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Pharmacological Treatment of Neuropsychiatric Symptoms in Huntington's Disease: A Systematic Review

Movement Disorders Clinical Practice, Volume 12, Issue 4, Page 418-431, April 2025.
ABSTRACT Background Studies focusing on the treatment of neuropsychiatric symptoms (NPS) in Huntington's disease (HD) are scarce and show a wide variation in design, outcome measures and methodological quality. The effectiveness of pharmacological treatment of NPS in HD has not been systematically reviewed so far.
Ruben L. Andriessen, Mayke Oosterloo, Jory Molema, Maud M.J. Daemen, David E.J. Linden, Albert F.G. Leentjens   +5 more
wiley   +1 more source

Energy Expenditure Due to Physical Activity Is Not Increased to Achieve Intended Weight Loss [PDF]

, 2015
Reduced physical activity and almost unlimited availability of food are major contributors to the development of obesity. With the decline of strenuous work, energy expenditure due to spontaneous physical activity has attracted increasing attention.
Burkert, Silke, Elbelt, Ulf, Knoll, Nina, Schuetz, Tatjana   +3 more
core   +2 more sources