Antidepressant monotherapy is a first-line treatment for depression; however, not all sufferers will adequately respond to treatment. When treating a patient with treatment-resistant depression, the clinician needs to consider all factors which may ...
Beasley +47 more
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Contribution of physiological dynamics in predicting major depressive disorder severity
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès +11 more
wiley +1 more source
P2X7 receptor: an emerging target in central nervous system diseases. [PDF]
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a potential drug target because of its widespread involvement in inflammatory diseases as a key regulatory element of the inflammasome complex.
Illes, P., Sperlágh, Beáta
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Alteration of Forebrain Neurogenesis after Cervical Spinal Cord Injury in the Adult Rat [PDF]
Spinal cord injury (SCI) triggers a complex cellular response at the injury site, leading to the formation of a dense scar tissue. Despite this local tissue remodeling, the consequences of SCI at the cellular level in distant rostral sites (i.e.
Marie-Solenne eFELIX +8 more
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The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions [PDF]
The present work represents a detailed description of our current understanding and knowledge of the epidemiology, etiopathogenesis and clinical manifestations of mood disorders, their comorbidity and overlap, and the effect of variables such as gender ...
Konstantinos N Fountoulakis +245 more
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Energy Expenditure Due to Physical Activity Is Not Increased to Achieve Intended Weight Loss [PDF]
Reduced physical activity and almost unlimited availability of food are major contributors to the development of obesity. With the decline of strenuous work, energy expenditure due to spontaneous physical activity has attracted increasing attention.
Burkert, Silke +3 more
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Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]
Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
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Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats [PDF]
BACKGROUND: Many neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Susceptibility to stress and depression is individually different.
Craig R Tomlinson +7 more
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]
Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
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Neurotrophins and neuronal plasticity in the action of antidepressants and morphine [PDF]
Neuronal plasticity is a well characterized phenomenon in the developing and adult brain. It refers to capasity of a single neuron to modify morphology, synaptic connections and activity.
Sairanen, Mikko
core

