Results 51 to 60 of about 4,715 (140)

Olanzapine / fluoxetine combination for treatment resistant depression : efficacy and clinical utility

open access: yes, 2008
Antidepressant monotherapy is a first-line treatment for depression; however, not all sufferers will adequately respond to treatment. When treating a patient with treatment-resistant depression, the clinician needs to consider all factors which may ...
Beasley   +47 more
core   +1 more source

Contribution of physiological dynamics in predicting major depressive disorder severity

open access: yesPsychophysiology, Volume 62, Issue 2, February 2025.
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès   +11 more
wiley   +1 more source

P2X7 receptor: an emerging target in central nervous system diseases. [PDF]

open access: yes, 2014
The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a potential drug target because of its widespread involvement in inflammatory diseases as a key regulatory element of the inflammasome complex.
Illes, P., Sperlágh, Beáta
core   +1 more source

Alteration of Forebrain Neurogenesis after Cervical Spinal Cord Injury in the Adult Rat [PDF]

open access: yes, 2012
Spinal cord injury (SCI) triggers a complex cellular response at the injury site, leading to the formation of a dense scar tissue. Despite this local tissue remodeling, the consequences of SCI at the cellular level in distant rostral sites (i.e.
Marie-Solenne eFELIX   +8 more
core   +1 more source

The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions [PDF]

open access: yes, 2010
The present work represents a detailed description of our current understanding and knowledge of the epidemiology, etiopathogenesis and clinical manifestations of mood disorders, their comorbidity and overlap, and the effect of variables such as gender ...
Konstantinos N Fountoulakis   +245 more
core   +1 more source

Energy Expenditure Due to Physical Activity Is Not Increased to Achieve Intended Weight Loss [PDF]

open access: yes, 2015
Reduced physical activity and almost unlimited availability of food are major contributors to the development of obesity. With the decline of strenuous work, energy expenditure due to spontaneous physical activity has attracted increasing attention.
Burkert, Silke   +3 more
core   +2 more sources

Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]

open access: yes, 2003
Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
core   +1 more source

Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats [PDF]

open access: yes, 2014
BACKGROUND: Many neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Susceptibility to stress and depression is individually different.
Craig R Tomlinson   +7 more
core   +1 more source

Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]

open access: yes, 2018
Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core   +1 more source

Neurotrophins and neuronal plasticity in the action of antidepressants and morphine [PDF]

open access: yes, 2007
Neuronal plasticity is a well characterized phenomenon in the developing and adult brain. It refers to capasity of a single neuron to modify morphology, synaptic connections and activity.
Sairanen, Mikko
core  

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