Results 41 to 50 of about 4,715 (140)

The Blue Light‐Responsive Lateral Pathway of the Retinohypothalamic Tract Promotes Endocannabinoid‐Driven Modulation of Orexin Neurons

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Blue light stimulation of ipRGCs leads to endocannabinoid‐mediated modulation of orexin neuron activity via the retinohypothalamic network. (1) In the first step, blue light‐induced glutamate release from VGluT1/CB1‐positive input depolarizes the OX‐A neuron (red) in the PFH; (2) This depolarization triggers the biosynthesis and release of 2‐AG (green ...
Nicola Forte, Roberta Imperatore, Brenda Marfella, Alessandro Nicois, Roberta Verde, Letizia Palomba, Vincenzo Di Marzo, Luigia Cristino   +7 more
wiley   +1 more source

Class effect of pharmacotherapy in bipolar disorder: fact or misbelief? [PDF]

, 2011
BACKGROUND: Anecdotal reports suggests that most clinicians treat medications as belonging to a class with regard to all therapeutic indications; this means that the whole 'class' of drugs is considered to possesses a specific therapeutic action.
Eduard Vieta, Konstantinos N Fountoulakis, Xenia Gonda, Zoltan Rihmer   +3 more
core   +3 more sources

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

MedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes, Patrizia Rubini, Henning Ulrich, Hai‐Yan Yin, Yong Tang   +4 more
wiley   +1 more source

Perillaldehyde Improves Parkinson‐Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study uncovers that stress granules (SGs) are involved in the pathogenesis of Parkinson's disease (PD). Perillaldehyde (PAE) can improve Parkinson‐like deficits in preclinical models by directly binding to G3BP and instigating liquid–liquid phase separation (LLPS) of G3BP.
Minglv Fang, Lingling Luo, Youjia Chen, Ying Liu, Yingxuan Yan, Fei Wang, Yan Zou, Huanhu Zhu, Xiaojun Wu, Zhigang Jin, Cheng Huang, Yu Zhang, Shengjie Fan   +12 more
wiley   +1 more source

Pharmacological Treatment of Neuropsychiatric Symptoms in Huntington's Disease: A Systematic Review

Movement Disorders Clinical Practice, Volume 12, Issue 4, Page 418-431, April 2025.
ABSTRACT Background Studies focusing on the treatment of neuropsychiatric symptoms (NPS) in Huntington's disease (HD) are scarce and show a wide variation in design, outcome measures and methodological quality. The effectiveness of pharmacological treatment of NPS in HD has not been systematically reviewed so far.
Ruben L. Andriessen, Mayke Oosterloo, Jory Molema, Maud M.J. Daemen, David E.J. Linden, Albert F.G. Leentjens   +5 more
wiley   +1 more source

Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.
Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Taku Nagai, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Cognitive behavioural therapy for anxiety disorders in children and adolescents [PDF]

, 2018
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To carry out a meta‐analysis of identified studies to determine whether CBT leads to remission of 1) the primary child/adolescent anxiety disorder and 2) all ...
Achenbach, Ale, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Angold, APA, Barrett, Barrington, Beck, Beidel, Bennett, Birmaher, Bittner, Brown, Cartwright-Hatton, Chorpita, Copeland, Crowe, Essau, Essau, Evans, Fineberg, Galla, Gillies, Greca, Higgins, Hill, Hirshfeld-Becker, Holland, James, James, Keeton, Kendall, Kendall, Kendall, Kendall, Kendall, Kovacs, Kushner, Last, Last, Lyneham, March, Masia-Warner, Merikangas, Moher, Monga, Murphy, Myers, NICE, O'Kearney, Pennant, Peris, Peris, Pine, Polanczyk, Rao, Reardon, Reaven, Reynolds, Reynolds, Sanchez-Garcia, Schleider, Schneider, Settipani, Shaffer, Silverman, Silverman, Silverman, Southam-Gerow, Spence, Spielberger, Thirlwall, Ung, Waite, Waite, Wang, Warner, Warwick, Waters, White, Whiteside, Wood, World Health Organization (WHO), World Health Organization (WHO), Young   +87 more
core   +1 more source

Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
UB exerts antidepressant activity and its modulation of microglia activation and neuroinflammation, balanced M1/M2 polarization via the SIRT1‐FOXO1 axis. ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) and its regulatory role in microglia‐
Cuilan Liu, Di Zhao, Guoxing Yu, HengWei Du, Lihong Xu, Yifan Cao, Minghu Cui, Wentao Wang, Dan Wang, Jing Liu, Fantao Meng, Fengai Hu, Wei Li, Jing Du, Chen Li   +14 more
wiley   +1 more source

Antidepressants for insomnia in adults [PDF]

, 2018
Background Insomnia disorder is a subjective condition of unsatisfactory sleep (e.g. sleep onset, maintenance, early waking, impairment of daytime functioning).
Adam, Ahmed, Altena, Auld, Aversa Lopes, Baglioni, Balter, Bon, Botros, Boyle, Breslau, Buscemi, Buysse, Carney, Chen, Cheuk, Chevalier, Committee on Safety of Medicines, Corruble, Edinger, Everitt, Fairweather, Fava, Ferrero, Finnerty, Friedmann, Gillin, Hajak, Hajak, Hamilton, Herman, Ishigooka, Ivgy-May, Ivgy-May, Karsten, Kaynak, Khazaie, Krystal, Krystal, Krystal, Krystal, Krystal, Krystal, Lai, Lankford, LeBlanc, Leger, Lemoine, Mayer, Mayers, Mellinger, Miljatovic, Moher, Moon, Morin, Morin, Morin, Morin, Morlock, Mychaskiw, Neckelmann, NIH, Nissen, Ohayon, Palesh, Palomaki, Perlis, Philip, Reynolds, Riemann, Riemann, Rios Romenets, Roth, Roth, Rush, Ruwe, Saarto, Sateia, Satterlee, Scharf, Shell, Shirazi, Sivertsen, Stein, Stein, Stephenson, Thaler, Vgontzas, Wade, Walsh, Walsh, Ware, Wilson, Wilson, World Health Organization, Wu, Zhou   +96 more
core   +1 more source

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 3, Page 922-938, March 2025.
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning   +7 more
wiley   +1 more source