Results 31 to 40 of about 3,329 (118)

Mechanism of action of antidepressive agents

, 2013
Antidepresivi koje se danas koriste u liječenju depresije povećavaju raspoloživost monoamina. Taj učinak postižu na različite načine, najčešće sprječavanjem ponovne pohrane monoamina, blokadom enzima za razgradnju, ili blokadom receptora.
Šagud, Marina, Mihaljević-Peleš, Alma, Vuksan-Ćusa, Bjanka, Brataljenović, Tomo   +3 more
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Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.
Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Taku Nagai, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Antidepresivos de nueva generación en neuropatía diabética dolorosa

, 2011
The incidence of diabetic neuropathy increases with the duration of diabetes and the degree of hyperglycaemia. Pain is one of the mostcommon and incapacitating symptoms of diabetic neuropathy and itspharmacological control is complex.
Carlos B. Moreno, Ángela M. Gutiérrez-Álvarez   +1 more
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Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology

, 2014
This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and clinical management, including recognition, acute ...
den Boer, J.A., Fineberg, N.A., Bandelow, B., Davies, S., Nutt, David J, Wee, N. van der, Fineberg, Naomi, Scott, Jan, O'Neill, C., Anderson, I.M., Nutt, D.J., O’Neill, C., Scott, J., Allgulander, Christer, Christmas, D.M., Christmas, David M, Fineberg, N., Davies, Simon, Allgulander, C., Anderson, Ian M., McCrone, P., Wittchen, H-U, Christmas, David M., van der Wee, N., Anderson, Ian M, Malizia, A., Nutt, David J., O'Neill, Catherine, Baldwin, D.S., Lidbetter, N., Lidbetter, Nicky, Bandelow, Borwin, Nabarro, Daniel, Malizia, Andrea, McCrone, Paul, van der Wee, Nic, Wittchen, Hans-Ulrich, Baldwin, David S., Baldwin, David S, den Boer, Johan A, Nabarro, D., Boer, J.A. den, Wittchen, H.U., Fineberg, Naomi A., den Boer, Johan A.   +44 more
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Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
UB exerts antidepressant activity and its modulation of microglia activation and neuroinflammation, balanced M1/M2 polarization via the SIRT1‐FOXO1 axis. ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) and its regulatory role in microglia‐
Cuilan Liu, Di Zhao, Guoxing Yu, HengWei Du, Lihong Xu, Yifan Cao, Minghu Cui, Wentao Wang, Dan Wang, Jing Liu, Fantao Meng, Fengai Hu, Wei Li, Jing Du, Chen Li   +14 more
wiley   +1 more source

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 3, Page 922-938, March 2025.
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning   +7 more
wiley   +1 more source

Contribution of physiological dynamics in predicting major depressive disorder severity

Psychophysiology, Volume 62, Issue 2, February 2025.
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès, Spyridon Kontaxis, Sara Siddi, Mar Posadas‐de Miguel, Concepción de la Cámara, Maria Luisa Bernal, Thais Castro Ribeiro, Pablo Laguna, Llorenç Badiella, Raquel Bailón, Josep Maria Haro, Jordi Aguiló   +11 more
wiley   +1 more source

Role of G protein coupled inwardly rectifier K+ channels (GIRK) on the neurobiology depression [PDF]

, 2012
353 págs.[EN] Major depression is a recurrent or chronic mood disorder with impaired psychosocial function, and an increased tendency of relapse for patients who fail to reach remission. In industrialized societies, it affects 15% of the population being
Fernández Aedo, Irrintzi
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In-vitro-effects of antidepressants on mitochondrial respiratory chain complexes in human hippocampus and prefrontal cortex

, 2012
Ausgehend von Literaturdaten, die auf einen möglichen Zusammenhang zwischen dem Auftreten extrapyramidal-motorischer Störungen (EPMS) unter Neuroleptika- Therapie und hemmenden Effekten dieser Psychopharmaka auf die Enzymkomplexe der mitochondrialen ...
Schellhaas, Barbara
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Investigação do efeito do ácido ascórbico em modelos animais preditivos de ação antidepressiva [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Ascorbic acid, commonly known as vitamin C, is a water-soluble antioxidant vitamin that participates in a wide ...
Binfaré, Ricardo Wabner
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