Overstated association between adolescent physical fitness and adulthood depression risk due to familial factors. [PDF]
J Intern MedAbstract Objective Examine the association between adolescent cardiorespiratory fitness and future risk of depression and dispensation of antidepressants, including the role of familial confounding. Methods A cohort study with sibling‐comparisons based on Swedish men who participated in mandatory military conscription examinations from 1972 to 1995 ...
Ballin M +4 more
europepmc +2 more sources
Lithium Augmentation in Treatment-Resistant Depression: A Qualitative Review of the Literature. [PDF]
PharmacotherapyABSTRACT Depression is the leading cause of disability worldwide, affecting people of all ages. Both pharmacological and non‐pharmacological therapies are available for its treatment. However, some patients do not respond to first‐line pharmacological interventions, referred to as treatment‐resistant depression (TRD).
Acero-González A +8 more
europepmc +2 more sources
PET studies of the serotonin system in major depression and its treatment [PDF]
, 2014 The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants.
Tiger, Mikael
core +1 more source
Insuficiência Hepática Aguda Induzida pela Trazodona e Diazepam [PDF]
, 2016 Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the
Barroso, E +5 more
core +1 more source
Cost-effectiveness analysis of pharmaceutical treatment options in the first-line management of major depressive disorder in Belgium [PDF]
, 2014 The objective of this study was to assess the cost effectiveness of commonly used antidepressants as first-line treatment of major depressive disorder (MDD) in Belgium.
Annemans, Lieven +5 more
core +2 more sources
Antidepressants versus placebo for depression in primary care [PDF]
, 2009 Background Concern has been expressed about the relevance of secondary care studies to primary care patients specifically about the effectiveness of antidepressant medication.
Arroll, Bruce +7 more
core +3 more sources
Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]
, 2018 Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V +15 more
core +2 more sources
Automatic summarization of MEDLINE citations for evidence-based medical treatment: A topic-oriented evaluation [PDF]
, 2008 As the number of electronic biomedical textual resources increases, it becomes harder for physicians to find useful answers at the point of care. Information retrieval applications provide access to databases; however, little research has been done on ...
Fiszman, Marcelo +3 more
core +1 more source
Transgenerational inheritance of paternal neurobehavioral phenotypes: stress, addiction, ageing and metabolism [PDF]
, 2015 Epigenetic modulation is found to get involved in multiple neurobehavioral processes. It is believed that different types of environmental stimuli could alter the epigenome of the whole brain or related neural circuits, subsequently contributing to the ...
Arias-Carrión, Oscar +9 more
core +1 more source
Which placebo to cure depression? A thought-provoking network meta-analysis [PDF]
, 2013 BACKGROUND: Antidepressants are often considered to be mere placebos despite the fact that meta-analyses are able to rank them. It follows that it should also be possible to rank different placebos, which are all made of sucrose.
Anne Solène Maria +5 more
core +3 more sources