Efficacy of bupropion and cognitive behavioral therapy in the treatment of methamphetamine use disorder: a systematic review and meta-analysis [PDF]
Objectives: We assessed the efficacy of cognitive behavioral therapy and bupropion compared to cognitive behavioral therapy alone for methamphetamine use disorder. Methods: The selection criteria for this systematic review study with meta-analysis were
Luis Fernando Maya Apuy +2 more
doaj +1 more source
Adjunctive antidepressive pharmacotherapy in schizophrenia patients
Depressive symptoms during long-term course of schizophrenia constitute an important and frequent clinical problem. They may occur either as stand-alone major depressive episodes (MDEs) or as part of the schizophrenic negative syndrome.
M. Zink
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Anxiolytic and antidepressant effect of zinc on rats and its impact on general behavioural parameters [PDF]
Background/Aim. Zinc is an essential element which has considerable interaction with gamma-aminobutyric acid A type receptors (GABAA) and glutamate receptors in the central nervous system (CNS).
Samardžić Janko +8 more
doaj +1 more source
BackgroundAntidepressant treatment is one of the most effective ways of relieving or curing depressive symptoms in patients with major depressive disorder (MDD).
Li Duan +7 more
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Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Belelli, Delia +3 more
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Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]
Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash +4 more
core +2 more sources
Antidepressant drugs and the response in the placebo group: the real problem lies in our understanding of the issue [PDF]
In a recent paper, Horder and colleagues (Horder et al., 2010, J Psychopharmacol 25: 1277–1288) have suggested that the mainproblem in the Kirsch analysis is methodological. We argue that the results are similar irrespective of the method used.
Bech P +8 more
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Clinical relevance and treatment possibilities of bipolar rapid cycling [PDF]
Bipolar rapid cycling (RC) is defined as 4 or more affective episodes within 1 year. It has been postulated that RC is related to a poor response to lithium, to the same extent as mixed episodes or other atypical symptoms of the illness.
Amann, B. +3 more
core +1 more source
Management of bipolar depression
Patients with bipolar disorder spend more time in a depressed than manic state, even with individualized treatment. To date, bipolar depression is often misdiagnosed and ineffectively managed both for acute episodes and residual symptoms.
Jae Seung Chang, Kyooseob Ha
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Smoking and antidepressants pharmacokinetics: a systematic review [PDF]
Despite an increasingly recognized relationship between depression and smoking, little is known about how smoking influences antidepressant response and treatment outcomes.
Donato, H +3 more
core +1 more source

