Results 51 to 60 of about 4,667 (141)

Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline

British Journal of Pharmacology, Volume 182, Issue 7, Page 1466-1486, April 2025.
Background and Purpose Alterations in tryptophan‐kynurenine (TRP‐KYN) pathway are implicated in major depressive disorder (MDD). α7 nicotinic acetylcholine (α7nACh) receptor regulates the hypothalamic–pituitary–adrenal (HPA) axis. We have shown that deficiency of kynurenine 3‐monooxygenase (KMO) induces depression‐like behaviour via kynurenic acid ...
Masaya Hasegawa, Kazuo Kunisawa, Bolati Wulaer, Hisayoshi Kubota, Hitomi Kurahashi, Takatoshi Sakata, Honomi Ando, Suwako Fujigaki, Hidetsugu Fujigaki, Yasuko Yamamoto, Taku Nagai, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Catalytic enantioselective arylations: boron to zinc exchange as a powerful tool for the generation of transferable aryl groups [PDF]

, 2008
The transmetalation between boron and zinc is of great importance for application in organic synthesis, since it allows the formation of new carbon-carbon bonds between organometallic units and electrophiles.
BRAGA, Antonio L., LÜDTKE, Diogo S., PAIXÃO, Márcio W.   +2 more
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Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway

CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.
UB exerts antidepressant activity and its modulation of microglia activation and neuroinflammation, balanced M1/M2 polarization via the SIRT1‐FOXO1 axis. ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) and its regulatory role in microglia‐
Cuilan Liu, Di Zhao, Guoxing Yu, HengWei Du, Lihong Xu, Yifan Cao, Minghu Cui, Wentao Wang, Dan Wang, Jing Liu, Fantao Meng, Fengai Hu, Wei Li, Jing Du, Chen Li   +14 more
wiley   +1 more source

Treatments for spasticity and pain in multiple sclerosis: a systematic review [PDF]

, 2003
Objectives: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness.
Beard, S.M., Hunn, A., Wight, J.
core   +1 more source

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 3, Page 922-938, March 2025.
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning   +7 more
wiley   +1 more source

Contribution of physiological dynamics in predicting major depressive disorder severity

Psychophysiology, Volume 62, Issue 2, February 2025.
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès, Spyridon Kontaxis, Sara Siddi, Mar Posadas‐de Miguel, Concepción de la Cámara, Maria Luisa Bernal, Thais Castro Ribeiro, Pablo Laguna, Llorenç Badiella, Raquel Bailón, Josep Maria Haro, Jordi Aguiló   +11 more
wiley   +1 more source

Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats [PDF]

, 2014
BACKGROUND: Many neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Susceptibility to stress and depression is individually different.
Craig R Tomlinson, Despina Sanoudou, Dimitris Nasias, Margarita Papandreou, Marianna Kouskou, Panagiotis A Tsonis, Pothitos M Pitychoutis, Zeta Papadopoulou-Daifoti   +7 more
core   +1 more source

Alteration of Forebrain Neurogenesis after Cervical Spinal Cord Injury in the Adult Rat [PDF]

, 2012
Spinal cord injury (SCI) triggers a complex cellular response at the injury site, leading to the formation of a dense scar tissue. Despite this local tissue remodeling, the consequences of SCI at the cellular level in distant rostral sites (i.e.
Marie-Solenne eFELIX, Natalia ePopa, Mehdi eDJELLOUL, José eBoucraut, Patrick eGauthier, Sylvian eBauer, Sylvian eBauer, Valery A Matarazzo, Valery A Matarazzo   +8 more
core   +1 more source

Neurotrophins and neuronal plasticity in the action of antidepressants and morphine [PDF]

, 2007
Neuronal plasticity is a well characterized phenomenon in the developing and adult brain. It refers to capasity of a single neuron to modify morphology, synaptic connections and activity.
Sairanen, Mikko
core  

Cognitive behavioural therapy for anxiety disorders in children and adolescents [PDF]

, 2018
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To carry out a meta‐analysis of identified studies to determine whether CBT leads to remission of 1) the primary child/adolescent anxiety disorder and 2) all ...
Achenbach, Ale, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, American Psychiatric Association, Angold, APA, Barrett, Barrington, Beck, Beidel, Bennett, Birmaher, Bittner, Brown, Cartwright-Hatton, Chorpita, Copeland, Crowe, Essau, Essau, Evans, Fineberg, Galla, Gillies, Greca, Higgins, Hill, Hirshfeld-Becker, Holland, James, James, Keeton, Kendall, Kendall, Kendall, Kendall, Kendall, Kovacs, Kushner, Last, Last, Lyneham, March, Masia-Warner, Merikangas, Moher, Monga, Murphy, Myers, NICE, O'Kearney, Pennant, Peris, Peris, Pine, Polanczyk, Rao, Reardon, Reaven, Reynolds, Reynolds, Sanchez-Garcia, Schleider, Schneider, Settipani, Shaffer, Silverman, Silverman, Silverman, Southam-Gerow, Spence, Spielberger, Thirlwall, Ung, Waite, Waite, Wang, Warner, Warwick, Waters, White, Whiteside, Wood, World Health Organization (WHO), World Health Organization (WHO), Young   +87 more
core   +1 more source