Results 61 to 70 of about 66,382 (184)

Transgenerational inheritance of paternal neurobehavioral phenotypes: stress, addiction, ageing and metabolism [PDF]

, 2015
Epigenetic modulation is found to get involved in multiple neurobehavioral processes. It is believed that different types of environmental stimuli could alter the epigenome of the whole brain or related neural circuits, subsequently contributing to the ...
Arias-Carrión, Oscar, Campos, Carlos, Hou, Gonglin, Li, Ang, Machado, Sergio, Ouyang, Huan, Rocha, Nuno, So, Kwok Fai, Sun, Xin, Yuan, Ti-Fei   +9 more
core   +1 more source

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

Journal of Medicinal Chemistry, 2012
On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial properties.
A. Nagle, Tao Wu, K. Kuhen, Kerstin Gagaring, Rachel Borboa, C. Francek, Zhong Chen, David M. Plouffe, Xuena Lin, Christopher Caldwell, J. Ek, S. Skolnik, Fenghua Liu, Jianling Wang, Jonathan Chang, Chun Xing Li, Bo Liu, T. Hollenbeck, T. Tuntland, J. Isbell, Tiffany Chuan, Philip B. Alper, Christoph Fischli, R. Brun, Suresh B. Lakshminarayana, M. Rottmann, T. Diagana, E. Winzeler, R. Glynne, D. Tully, A. Chatterjee   +30 more
semanticscholar   +1 more source

Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways

Brain and Behavior, Volume 15, Issue 1, January 2025.
Agmatine significantly reduced tremors, ameliorated anxiety‐like behaviors, and attenuated harmaline‐induced locomotor deficits. At the molecular level, agmatine significantly suppressed the overexpression of Lingo‐1 elicited by harmaline. Moreover, IL‐6 expression was attenuated to an extent comparable to control levels.
Zeynab Pirmoradi, Zahra Esmaili, Mohsen Nakhaie, Kristi A. Kohlmeier, Mohammad Shabani, Moazamehosadat Razavinasab, Mehran Ilaghi   +6 more
wiley   +1 more source

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Journal of Medicinal Chemistry
Despite the record-breaking discovery, development and approval of vaccines and antiviral therapeutics such as Paxlovid, coronavirus disease 2019 (COVID-19) remained the fourth leading cause of death in the world and third highest in the United States in
C. Allerton, Joel T. Arcari, L. Aschenbrenner, Melissa Avery, B. Bechle, Mohammad Amin Behzadi, B. Boras, Leanne M. Buzon, Rhonda D. Cardin, Natasha R Catlin, Anthony A Carlo, Karen J. Coffman, A. Dantonio, Li Di, Heather Eng, Kathleen A. Farley, R. Ferre, Steven S Gernhardt, Scott A Gibson, S. Greasley, Siennah R. Greenfield, B. Hurst, A. Kalgutkar, Emi Kimito, L. Lanyon, Gabrielle H Lovett, Yajing Lian, Wei Liu, Luis A Martínez Alsina, Stephen Noell, R. Obach, Dafydd R Owen, Nandini C Patel, Devendra K. Rai, M. Reese, H. Rothan, Sylvie Sakata, M. Sammons, Jean Sathish, Raman Sharma, C. Steppan, J. Tuttle, P. Verhoest, Liuqing Wei, Qingyi Yang, Irina Yurgelonis, Yuao Zhu   +46 more
semanticscholar   +1 more source

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han, Zheng Zhao, Tinghui Mao, Man Gao, Xue Yang, Yan Gao   +5 more
wiley   +1 more source

ADN-1184, a monoaminergic ligand with 5-HT_{6/7} receptor antagonist action, exhibits activity in animal models of anxiety [PDF]

, 2016
Behavioral and psychological symptoms of dementia (BPSD) include apathy, sleep problems, irritability, wandering, elation, agitation/aggression, and mood disorders such as depression and/or anxiety.
Bieńkowski, Przemysław, Jastrzębska-Więsek, Magdalena, Kołaczkowski, Marcin, Mierzejewski, Paweł, Partyka, Anna, Wasik, Anna, Wesołowska, Anna   +6 more
core   +1 more source

Cognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
All patients underwent a 3‐week intervention of combined electromagnetic stimulation. Scale assessments and magnetic resonance imaging data collection were performed before and after the intervention, followed by scale assessments at the eighth week.
Hetong Zhou, Minmin Wang, Ting Xu, Xiaomei Zhang, Xudong Zhao, Lili Tang, Pengfei Zhao, Dandan Wang, Jianbo Lai, Fei Wang, Shaomin Zhang, Shaohua Hu   +11 more
wiley   +1 more source

Antidepressant use and the risk of mood instability [PDF]

, 2020
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Teodoro, Tomás
core   +1 more source

Novel treatment options in depression and psychosis

Neuropsychiatric Disease and Treatment, 2018
Eva Ceskova, Petr Silhan Department of Psychiatry, University Hospital Ostrava, Ostrava, Czech Republic Abstract: In spite of tremendous development in central nervous system research, current treatment is suboptimal, especially in severe mental ...
Ceskova E, Silhan P
doaj  

Which placebo to cure depression? A thought-provoking network meta-analysis [PDF]

, 2013
BACKGROUND: Antidepressants are often considered to be mere placebos despite the fact that meta-analyses are able to rank them. It follows that it should also be possible to rank different placebos, which are all made of sucrose.
Anne Solène Maria, Bruno Falissard, Bruno Millet, Florian Naudet, Jean Michel Reymann, Philippe Charlier   +5 more
core   +3 more sources