Results 121 to 130 of about 1,519,564 (181)

Azetidine derivatives of tricyclic antidepressant agents

Journal of Medicinal Chemistry, 1979
Tricyclic derivatives of azetidine were synthesized and screened for their potential antidepressant activity. The active series had the tricyclic ring attached to position 1 and a basic group in position 3 of the azetidine. The most interesting compounds were comparable to the reference standards for reserpine antagonism in mice, the most active being ...
P, Melloni, A, Della Torre, M, Meroni, A, Ambrosini, A C, Rossi   +4 more
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Tricyclic Antidepressants in Obsessive-Compulsive Disorder Antiobsessional or Antidepressant Agents?

The Journal of Nervous and Mental Disease, 1983
The response to tricyclic antidepressants of eight obsessive-compulsive patients was assessed at pretreatment and at 4, 8, and 12 weeks of treatment, with the aim of delineating differential rates of improvement, or desynchrony, between the various symptoms. Change in obsessive-compulsive symptoms paralleled change in depression and anxiety, suggesting
M, Mavissakalian, L, Michelson
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Combined intoxication with tricyclic antidepressive and neuroleptic agents.

, 1996
We report the case of a patient who co-ingested a tricyclic antidepressant (2500 mg of doxepin) and a neuroleptic drug (3500 mg of prothipendyl). Following overdose either agent can affect the central nervous and cardiovascular systems, inducing arrhythmias, conduction disturbances and hypotension.
Diltoer, Marc, Poelmans, Luc, Hubloue, Ives, Spapen, Herbert, Huyghens, Luc   +4 more
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Antidepressants II: tricyclic agents

2002
Abstract Tricyclic antidepressants (TCA) were first synthesized in the 1940s by chemists looking for drugs to act as sedatives, antihistamines, and anti-parkinsonian drugs (Baldessarini, 1996). Use in depression was first reported in the late 1950s, and hundreds of studies have confirmed their effectiveness in adult populations.
Karl Gundersen, Barbara Geller
openaire   +1 more source

Tricyclic antidepressants in obsessive-compulsive disorder: antiobsessional or antidepressant agents? II

American Journal of Psychiatry, 1985
The authors explored the relationship between the antiobsessional and antidepressant effects of tricyclic drugs in primary obsessive-compulsive disorders. Study 1 consisted of a controlled 12-week trial with clomipramine (N = 7) and placebo (N = 5); study 2 analyzed the pooled data from 15 patients uniformly selected and treated with either ...
M, Mavissakalian, S M, Turner, L, Michelson, R, Jacob   +3 more
openaire   +2 more sources

Tricyclic Neovibsanin Scaffold (TCNS) as an Effective Antidepressant Agent

Drug Research, 2015
Neovibsanin type natural products were found to display neurite outgrowth activity in PC12 cells. This suggests that such type of compounds could be promising candidates for the development of novel therapeutic agents to treat neurological diseases.
D-D, Qiao, G-L, Mi, M-Q, Tang
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Antidepressant agents: from tricyclics to serotonin uptake inhibitors

Psychological Medicine, 1998
Background. The number of antidepressant drugs available in the market has grown rapidly in the last few years. The present paper underlines some of the pre-clinical and clinical problems that call close attention from the regulatory authorities when approving new drugs.Methods. We present here a review of the literature.Results.
Garattini S., BARBUI, Corrado, Saraceno B.   +2 more
openaire   +3 more sources

Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents

Annals of Allergy, Asthma & Immunology, 2006
Aromatic anticonvulsant agents such as carbamazepine and phenytoin can induce anticonvulsant hypersensitivity syndrome (AHS) at a frequency of 1 in 10,000 to 1 in 1,000 treated patients. The hypersensitivity syndrome is a potentially life-threatening adverse drug reaction with multiorgan involvement, and incidental reexposure must be strictly avoided ...
Cornelia S, Seitz, Petra, Pfeuffer, Petra, Raith, Eva B, Bröcker, Axel, Trautmann   +4 more
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ChemInform Abstract: AZETIDINE DERIVATIVES OF TRICYCLIC ANTIDEPRESSANT AGENTS

Chemischer Informationsdienst, 1979
AbstractAuf dem im Formelschema skizzierten Wegen werden Azetidin‐Derivate wie (IV) und (X) dargestellt.
P. MELLONI, A. D. TORRE, M. MERONI, A. AMBROSINI, A. C. ROSSI   +4 more
openaire   +1 more source

Combined intoxication with a tricyclic antidepressive agent and a neuroleptic.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 1997
We report the case of a patient who co-ingested a tricyclic antidepressant (2500 mg of doxepin) and a neuroleptic drug (3500 mg of prothipendyl). Following overdose either agent can affect the central nervous and cardiovascular systems, inducing arrhythmias, conduction disturbances and hypotension.
M W, Diltoer, L W, Poelmans, I, Hubloue, H D, Spapen, V, Maes, L P, Huyghens   +5 more
openaire   +1 more source