Psychological Adverse Events and Associated Safety Profiles of Doxepin: A Pharmacovigilance Study Using VigiBase. [PDF]
Lee CY +6 more
europepmc +1 more source
Repeated intranasal esketamine augmentation in treatment-resistant obsessive-compulsive disorder with comorbid major depressive disorder: a prospective case series. [PDF]
López-Rodríguez S +6 more
europepmc +1 more source
The Effect of Use of Tricyclic Antidepressants or Serotonin-Norepinephrine Reuptake Inhibitors Versus Selective Serotonin Reuptake Inhibitors on the Risk of Urinary Tract Infection Among People With Multiple Sclerosis: A Nested Case-Control Study. [PDF]
Leung MWY +5 more
europepmc +1 more source
Mirtazapine Versus Other Antidepressive Agents for Depression
BACKGROUND: Mirtazapine has a unique mechanism of antidepressive action and is one of the commonly used antidepressants in clinical practice. OBJECTIVES: The aim of the present review was to assess the evidence on the efficacy and acceptability of ...
Andrea Cipriani +2 more
exaly +2 more sources
The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis
Antidepressive agents are one of the fastest-growing classes of prescribed drugs. However, the effects of antidepressive agents on bone density are controversial.
Ulrich Schweiger +2 more
exaly +2 more sources
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Azetidine derivatives of tricyclic antidepressant agents
Journal of Medicinal Chemistry, 1979Tricyclic derivatives of azetidine were synthesized and screened for their potential antidepressant activity. The active series had the tricyclic ring attached to position 1 and a basic group in position 3 of the azetidine. The most interesting compounds were comparable to the reference standards for reserpine antagonism in mice, the most active being ...
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Tricyclic Antidepressants in Obsessive-Compulsive Disorder Antiobsessional or Antidepressant Agents?
The Journal of Nervous and Mental Disease, 1983The response to tricyclic antidepressants of eight obsessive-compulsive patients was assessed at pretreatment and at 4, 8, and 12 weeks of treatment, with the aim of delineating differential rates of improvement, or desynchrony, between the various symptoms. Change in obsessive-compulsive symptoms paralleled change in depression and anxiety, suggesting
M, Mavissakalian, L, Michelson
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Antidepressants II: tricyclic agents
2002Abstract Tricyclic antidepressants (TCA) were first synthesized in the 1940s by chemists looking for drugs to act as sedatives, antihistamines, and anti-parkinsonian drugs (Baldessarini, 1996). Use in depression was first reported in the late 1950s, and hundreds of studies have confirmed their effectiveness in adult populations.
Karl Gundersen, Barbara Geller
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The authors explored the relationship between the antiobsessional and antidepressant effects of tricyclic drugs in primary obsessive-compulsive disorders. Study 1 consisted of a controlled 12-week trial with clomipramine (N = 7) and placebo (N = 5); study 2 analyzed the pooled data from 15 patients uniformly selected and treated with either ...
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