Results 1 to 10 of about 18,821 (217)

Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats [PDF]

Journal of Circadian Rhythms, 2018
The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine
Hiroshi Kawai, Natsumi Kodaira, Chika Tanaka, Takuya Ishibashi, Naomi Kudo, Yoichi Kawashima, Atsushi Mitsumoto   +6 more
doaj   +4 more sources

Possible involvement of keratinocyte-derived microvesicle particles in human photosensitivity disorders. [PDF]

Photochem Photobiol
In this model, ROS generated by UVB result in PAFR agonists acting upon the PAFR resulting in MVP generation release via the enzyme aSMase. In photosensitivity, there are increased ROS, resulting in augmented PAF agonists and increased MVP release. This process can be blocked by aSMase inhibitors.
Annamraju R, Owens MS, Thyagarajan A, Corbin DA, Sherwin CMT, Bryant J, Fisher GW, Owens WR, Ketter A, Umerani A, Rohan CA, Kemp MG, Crow RK, Travers JB.   +13 more
europepmc   +2 more sources

Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway

Neural Regeneration Research, 2016
Retinal ganglion cell (RGC) degeneration is irreversible in glaucoma and tyrosine kinase receptor B (TrkB)-associated signaling pathways have been implicated in the process.
Ming-lei Han, Guo-hua Liu, Jin Guo, Shu-juan Yu, Jing Huang   +4 more
doaj   +2 more sources

The effect of imipramine on the behavior of albino mice in presence of selenium

Libyan International Medical University Journal, 2016
Introduction: Imipramine, a tricyclic antidepressant used in the treatment of depression, anxiety, and other mental condition. Selenium is useful in managing depression and anxiety.
S Aburawi, S Baayo
doaj   +2 more sources

Antidepressant and Anxiolytic Effect of Tramadol as Compared to Imipramine, in Acute and Chronic Dosage in Rats

Journal of Aziz Fatimah Medical and Dental College, 2022
Objective: To assess the anti-depressant and anxiolytic effect of tramadol as compared to imipramine (approved antidepressant) in acute and chronic doses in rats.
Fiza Soomro, Nasreen Kazi, Aatir Hanif Rajput, Sadat Memon   +3 more
doaj   +1 more source

Further characterization of the effect of the prototypical antidepressant imipramine on the microstructure of licking for sucrose.

PLoS ONE, 2021
We previously reported that treatment with the prototypical antidepressant imipramine induced a dose-dependent reduction of the ingestion of a 10% sucrose solution, due to reduction of the licking burst number, thus suggesting reduced motivation and/or ...
Paolo S D'Aquila, Adriana Galistu
doaj   +1 more source

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

Frontiers in Oncology, 2021
BackgroundAnti-depressants have been reported to own anti-tumor potential types of cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not been elucidated.
Po-Fu Yueh, Yuan-Hao Lee, I-Tsang Chiang, I-Tsang Chiang, I-Tsang Chiang, Wei-Ting Chen, Keng-Li Lan, Keng-Li Lan, Cheng-Hsien Chen, Fei-Ting Hsu   +9 more
doaj   +1 more source

Effects of imipramine on cancer patients over-expressing Fascin1; description of the HITCLIF clinical trial

Frontiers in Oncology, 2023
BackgroundTumor invasion and metastasis are responsible for the majority of cancer-related deaths. The identification of molecules involved in these processes is crucial to design effective treatments that can halt the progression of cancer.
Antonio Asensi-Cantó, Antonio Asensi-Cantó, Antonio Asensi-Cantó, Edith Rodríguez-Braun, Asunción Beltrán-Videla, Ana María Hurtado, Ana María Hurtado, Pablo Conesa-Zamora, Pablo Conesa-Zamora   +8 more
doaj   +1 more source

Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats

Journal of Pharmacological Sciences, 2003
: The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats.
Yoshihisa Kitamura, Hiroaki Araki, Kazuhiko Shibata, Yutaka Gomita, Yoshiro Yoshiro   +4 more
doaj   +1 more source

Imipramine Accelerates Nonalcoholic Fatty Liver Disease, Renal Impairment, Diabetic Retinopathy, Insulin Resistance, and Urinary Chromium Loss in Obese Mice

Veterinary Sciences, 2021
Imipramine is a tricyclic antidepressant that has been approved for treating depression and anxiety in patients and animals and that has relatively mild side effects.
Geng-Ruei Chang, Po-Hsun Hou, Chao-Min Wang, Jen-Wei Lin, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Chee-Hong Chan, Yu-Chen Wang   +8 more
doaj   +1 more source