Results 21 to 30 of about 20,494 (215)

Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

Frontiers in Oncology, 2021
BackgroundAnti-depressants have been reported to own anti-tumor potential types of cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not been elucidated.
Po-Fu Yueh, Yuan-Hao Lee, I-Tsang Chiang, I-Tsang Chiang, I-Tsang Chiang, Wei-Ting Chen, Keng-Li Lan, Keng-Li Lan, Cheng-Hsien Chen, Fei-Ting Hsu   +9 more
doaj   +1 more source

Effects of imipramine on cancer patients over-expressing Fascin1; description of the HITCLIF clinical trial

Frontiers in Oncology, 2023
BackgroundTumor invasion and metastasis are responsible for the majority of cancer-related deaths. The identification of molecules involved in these processes is crucial to design effective treatments that can halt the progression of cancer.
Antonio Asensi-Cantó, Antonio Asensi-Cantó, Antonio Asensi-Cantó, Edith Rodríguez-Braun, Asunción Beltrán-Videla, Ana María Hurtado, Ana María Hurtado, Pablo Conesa-Zamora, Pablo Conesa-Zamora   +8 more
doaj   +1 more source

Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats

Journal of Pharmacological Sciences, 2003
: The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats.
Yoshihisa Kitamura, Hiroaki Araki, Kazuhiko Shibata, Yutaka Gomita, Yoshiro Yoshiro   +4 more
doaj   +1 more source

Imipramine Accelerates Nonalcoholic Fatty Liver Disease, Renal Impairment, Diabetic Retinopathy, Insulin Resistance, and Urinary Chromium Loss in Obese Mice

Veterinary Sciences, 2021
Imipramine is a tricyclic antidepressant that has been approved for treating depression and anxiety in patients and animals and that has relatively mild side effects.
Geng-Ruei Chang, Po-Hsun Hou, Chao-Min Wang, Jen-Wei Lin, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Chee-Hong Chan, Yu-Chen Wang   +8 more
doaj   +1 more source

Protomer of Imipramine Captured in Cucurbit[7]uril

, 2023
Small molecules possessing multiple proton-accessible sites are important not only to many biological systems but also to host–guest chemistry; their protonation states are causal to boosting or hindering specific host–guest interactions.
Hochan Lee (1372293), Kimoon Kim (1563838), Jiyeon Lee (77903), Jongcheol Seo (1355487), Hyerim Kim (5843204), Deepak R. Boraste (13923614)   +5 more
core   +2 more sources

EFFECT OF ESTRADIOL, IMIPRAMINE AND FLUOXETINE ON BRAIN SEROTONIN LEVELS IN OVARIECTOMIZED-INDUCED OSTEOPOROTIC RATS [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2017
Aim: The present study aimed to determine the effect of Estradiol, Imipramine and Fluoxetine on brain serotonin levels in ovariectomized-induced osteoporotic rats and to investigate the effect of previous treatments on Electron Microscope results in ...
Nora Zakaria
doaj   +1 more source

Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells

Journal of Pharmacological Sciences, 2003
We previously reported that NG108-15 cells contain intrinsic serotonin 2C receptor (5-HT2CR). The effects of imipramine, a 5-HT2CR antagonist, on cell growth, cell viability, and the 5-HT2CR mRNA level were investigated in this study.
Monrudee Sukma, Michihisa Tohda, Hiroshi Watanabe   +2 more
doaj   +1 more source

Beta-adrenergic receptor blockers effects on the antinociceptive action of imipramine against thermal induced pain in albino mice

Libyan International Medical University Journal, 2016
Introduction: Tricyclic antidepressant have been shown to be effective in treatment of pain of varying etiology, monoaminergic system seems to be implicated in this phenomena.
H A Zawia, F A Blaou, A S Elhwuegi
doaj   +1 more source

Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes

Journal of Pharmacological Sciences, 2012
Depression is one of the most prevalent and livelihood-threatening forms of mental illnesses and the neural circuitry underlying depression remains incompletely understood.
Katsura Takano, Hiroshi Yamasaki, Kenji Kawabe, Mitsuaki Moriyama, Yoichi Nakamura   +4 more
doaj   +1 more source

Intratympanic dexamethasone as an adjuvant to oral imipramine hydrochloride (Tofranil, a TCA) 25 mg twice daily in management of idiopathic unilateral subjective tinnitus

The Egyptian Journal of Otolaryngology, 2019
Background In this report, we summarize our clinical experience with intratympanic (IT) dexamethasone treatment for control of idiopathic unilateral tinnitus when used as an adjunct treatment with Tricyclic antidepressant (TCA) imipramine hydrochloride ...
Tamer A. Abo El Ezz, Fathy N. Fattoh, Tahany Rabie   +2 more
doaj   +1 more source