Results 31 to 40 of about 20,972 (210)

Imipramine in agoraphobia

Comprehensive Psychiatry, 1986
Abstract This article briefly and selectively reviews recent controlled trials of imipramine in agoraphobia. It is concluded that (1) imipramine enhances the effects of exposure treatments of agoraphobia probably due to facilitation of the process of habituation underlying repeated/prolonged exposure to phobic stimuli, (2) that imipramine doses in ...
openaire   +2 more sources

Imipramine decreases oesophageal pain perception in human male volunteers

, 1998
Background—Visceral hyperalgesia is a hallmark of functional gastrointestinal disorders. Antidepressants improve symptoms in these patients, although their mode of action is unclear.
P O Katz, D O Castell, P L Peghini
core   +1 more source

Effects of Tibetan medicine metacinnabar (β-HgS) combined with imipramine or sertraline on depression-like symptoms in mice

Frontiers in Pharmacology, 2022
Depression is a common mood disorder that has exhibited an increased incidence rate worldwide, but the overall clinical efficacy of antidepressants remains unsatisfactory.
Yajun Qiao, Yajun Qiao, Yajun Qiao, Cen Li, Cen Li, Ming Zhang, Ming Zhang, Xingfang Zhang, Xingfang Zhang, Lixin Wei, Lixin Wei, Keshen Cao, Xiaoyuan Zhang, Hongtao Bi, Tingting Gao, Tingting Gao   +15 more
doaj   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Studies on ¹⁴C-imipramine Metabolism in the Isolated Perfused Rat Liver

, 1974
An analytical procedure for the measurement of 14C-imipramine and its metabolites in liver, bile, and perfusion fluid has been studied using the isolated perfused rat liver technique. The extraction efficiency and specificity have been found to be high (
G. D. Bellward, Mervin Moldowan
core   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source

The CYP2C19(star)17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients

, 2010
CYP2C19 converts the tricyclic antidepressant imipramine to its active metabolite desipramine, which is subsequently inactivated by CYP2D6. The novel CYP2C19(star)17 allele causes ultrarapid metabolism of CYP2C19 substrates.
Rij, SVV, Gelder, Teun, Schenk, PW, van Vliet, M, Mathot, RAA, Bruijn, Jan, Vulto, Arnold; id_orcid, Fessem, Mariane, Lindemans, Jan, van Schaik, Ron   +9 more
core   +2 more sources

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Imipramine and its metabolites in human brain

, 1973
A quantitative and qualitative thin-layer chromatographic study of the distribution of imipramine and its metabolites in 13 different regions of the brain in a fatal case of intoxication has been made. A quantitative thin-layer chromatographic method for
Lars F Gram, Johs Christiansen
core   +1 more source