Results 41 to 50 of about 32,815 (232)
Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer’s disease pathology in the 5xFAD mouse
Acta Neuropathologica Communications, 2023 In Alzheimer’s disease (AD), reactive astrocytes produce extracellular vesicles (EVs) that affect mitochondria in neurons. Here, we show that Aβ-induced generation of the sphingolipid ceramide by acid sphingomyelinase (A-SMase) triggered proinflammatory ...Simone M. Crivelli, Zainuddin Quadri, Hemendra J. Vekaria, Zhihui Zhu, Priyanka Tripathi, Ahmed Elsherbini, Liping Zhang, Patrick G. Sullivan, Erhard Bieberich +8 moredoaj +1 more sourceA Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells
Advanced Science, EarlyView.A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk +13 morewiley +1 more sourcePost hoc analyses of the impact of previous medication on the efficacy of lisdexamfetamine dimesylate in the treatment of attention-deficit/hyperactivity disorder in a randomized, controlled trial [PDF]
, 2014 David R Coghill,1 Tobias Banaschewski,2 Michel Lecendreux,3 César Soutullo,4 Alessandro Zuddas,5 Ben Adeyi,6 Shaw Sorooshian7 1Division of Neuroscience, University of Dundee, Dundee, UK; 2Child and Adolescent Psychiatry and Psychotherapy, Central Alessandro Alessandro Zuddas, Ben Adeyi, Cesar Soutullo, David Coghill, Katharine Murkett, Michel Lecendreux, Shaw Sorooshian, Tobias Banaschewski +7 morecore +6 more sourcesSecreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus
Advanced Science, EarlyView.This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin +11 morewiley +1 more sourceChlorpromazine versus placebo for schizophrenia [PDF]
, 2014 BackgroundChlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia.ObjectivesTo review the effects of chlorpromazine compared with placebo, for the treatment of schizophrenia.Search methodsWe searched the ...Abrams, Abse, Acker, Adams, Affleck, Agarwal, Ahmed, Akimoto, Alpert, Alpert, Alson, Altman, Aman, American Psychiatric Association, American Psychiatric Association, Amin, Ananth, Andrews, Ashcroft, Awad, Ayers, Azima, B, Bagadia, Baker, Ban, Ban, Becker, Beech, Belmont, Benaim, Bennett, Birchwood, Bishop, Bland, Blumberg, Blumberg, Boer, Boissel, Bollini, Borison, Borison, Boullin, Bowes, Bressler, Brizer, Burnett, Cabrera Gomez, Caffey, Caffey, Caffey, Caldwell, Campbell, Campbell, Cardone, Casey, Casey, Chacon, Chacon, Childers, Chong, Chouinard, Chouinard, Chouinard-G, Claghorn, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Clark, Cobb, Cohen, Cole, Cole, Coons, Cooper, Cowden, Crane, Crane, Crane, Crow, Curry, Cutler, Dally, Danion, Daston, Daston, Davies, Davis, Dean, Dean, Denber, Denber, Denber, Desager, Divine, Donner, Douglas, Downing, Dube, Egger, Eitan, Ekdawi, Elbourne, Elkes, Engelhardt, Engelhardt, Engelhardt, Engelhardt, Engelhardt, Feldman, Fink, Fink, Fink, Fleming, Fleming, Foote, Forrest, Freed, Freedman, Freedman, Freedman, Freeman, Freeman, Freeman, Friedhoff, Fromm, Furukawa, Gaitz, Galbrecht, Galdi, Gallant, Gallant, Gardner, Gardos, Gardos, Gardos, Garfield, Garmezy, Gauthier, Gendron, Gibbs, Gibbs, Gilgash, Godwin-Austen, Goldberg, Goldberg, Goldberg, Goldberg, Goldberg, Goldberg, Goldman, Good, Graupner, Graupner, Green, Green, Greenberg, Griffiths, Grozier, Grygier, Gulliford, Guy, Guy, Gwynne, Hall, Hambrecht, Hamill, Hamilton, Hammond, Hamner, Hankoff, Hankoff, Hanlon, Hanlon, Harper, Hartley, Hartley, Hartley, Hartley, Hartmann, Haskell, Heilizer, Hekimian, Herrera, Herrmann, Herrmann, Herz, Higgins, Hill, Hine, Hoffer, Hoffer, Hogarty, Hogarty, Hogarty, Hogarty, Hogarty, Hogarty, Hollis, Hollister, Hollister, Hollister, Holt, Honigfeld, Hopkin, Hrushka, Huang, Hughes, Hurst, Hussar, Itil, Itil, Jadad, Jenicek, Jia, Johnstone, Johnstone, Jones, Jones, Joseph, Joshi, Jusic, Kabes, Kammerer, Kane, Kaplan, Kaplan, Kay, Kendler, Keskiner, Kim, Kimbell, King, King, Klein, Klein, Klein, Klein, Klein, Kopell, Kordas, Kornetsky, Kornetsky, Kornetsky, Kornetsky, Korol, Kovitz, Kramer, Kugler, Kupfer, Kurland, Kurland, Kurland, Kurland, Kurland, Kurland, Laborit, Lampe, Latz, Laurian, Leff, Leff, Leszek, Letemendia, Leucht, Leucht, Leucht, Levenstein, Levin, Levine, Levita, Lewis, Li, Liberman, Little, Long, Loranger, Lorr, Lucero, Lyberi, MacMillan, Maculans, Mahal, Majewski, Mandel, Marjerrison, Marrazzi, Marshall, Mason-Browne, Mason-Browne, Mathur, Mattila, McClelland, Mefferd, Melnyk, Merry, Michaux, Millar, Milne, Milstein, Milton, Mirsky, Mitchell, Mitchell, Moher, Monteleone, Morgenstern, Morton, Moss, Neal, Newbold, Nishikawa, Odejide, Okuma, Orzack, Osmakova, Overall, Paredes, Park, Pasamanick, Patterson, Payne, Peet, Peet, Pennington, Pfeiffer, Pietzcker, Pigache, Pigache, Pigache, Planansky, Platz, Pleasure, Pollack, Pollard, Praag, Praag, Prien, Prien, Prien, Prien, Primac, Quigley, Quinn, Raaska, Ragland, Raja, Ramu, Ramu, Rappaport, Rappaport, Rappaport, Rathod, Ray, Raymond, Reardon, Remr, Remr, Reschke, Rifkin, Rinaldi, Rivera Calimlim, Rosen, Rosen, Rosen, Rosenheck, Rosenthal, Rosner, Rudy, Rudy, Sainz, Sakalis, Saletu, Salisbury, Saretsky, Schiele, Schiele, Schmidt, Schooler, Schooler, Schulz, Schünemann, Seager, Sedvall, Serafetinides, Serafetinides, Serafetinides, Serafetinides, Serafetinides, Serafetinides, Serafetinides, Serafetinides, Shaskan, Shaskan, Shawver, Shepherd, Shopsin, Shopsin, Silver, Simon, Simon, Simpson, Simpson, Singh, Singh, Singh, Singh, Singh, Small, Smith, Smith, Smith, Smith, Somerville, Sommerness, South-East Region (Scotland) Therapeutic Trials Committee, Soyka, Spiegel, Spohn, Spohn, Sugerman, Sun, Syvalahti, Szymanski, Szymanski, Talbot, Tang, Tang, Tassis, Teja, Tenenblatt, Terminska, Tetreault, Tetreault, Tetreault, Thornley, Thornley, Thorpe, Tourlentes, Troshinsky, Turner, Turner, Ukoumunne, Urquhart, Vaughan, Vinar, Vinar, Volavka, Walsh, Warner, Weckowicz, Weir, Welbel, Whitehead, Wilcott, Wilson, Winkelman, Winter, Wode-Helgodt, Wold, Wolpert, Wyatt, Xia, Xiong, Yan, Yang, Yorkston, Yuan-Guang, Zeller, 王强, 金建烽 +486 morecore +1 more sourceAntidepressants and the risk of hyponatremia: A multi‐institutional cohort study using observational medical outcomes partnership—Common Data Model
British Journal of Clinical Pharmacology, EarlyView.Aim
Hyponatremia is a common yet potentially serious adverse event associated with antidepressants. Identifying the antidepressant class with the least risk of hyponatremia would improve patient safety. Methods
Using electronic medical records from 15 hospitals standardized into Observational Medical Outcomes Partnership Common Data Model (2003–2023 ...Kyungyeon Jung, Ju Hwan Kim, Da Eun Hyeon, Jeongmoon Ji, Min Young Lee, Hayun Choi, Dong Yun Lee, Min Woo Kim, Yoonmin Jang, Seonghoon Hwang, Jaehyeong Cho, Seok Young Song, Sang Youl Rhee, Jae Myung Cha, Won‐Woo Seo, Chang‐Won Jeong, Seung‐Jin Kwag, Woo Jin Kim, Jaeuk Hwang, Min‐ho Kim, Rae Woong Park, Ju‐Young Shin +21 morewiley +1 more sourceMirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]
, 2004 Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.Baghai, Thomas C., Laakmann, G., Schule, C. +2 morecore +1 more sourceImipramine Administration in Brucella abortus 2308-Infected Mice Restores Hippocampal Serotonin Levels, Muscle Strength, and Mood, and Decreases Spleen CFU Count
Pharmaceuticals, 2023 Brucellosis infection causes non-specific symptoms such as fever, chills, sweating, headaches, myalgia, arthralgia, anorexia, fatigue, and mood disorders. In mouse models, it has been associated with increased levels of IL-6, TNF-α, and IFN-γ, a decrease José Luis Maldonado-García, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Lenin Pavón, Luvia Sánchez-Torres, Gabriel Gutiérrez-Ospina, Manuel Iván Girón-Pérez, Gabriela Damian-Morales, Jesús Octavio Maldonado-Tapia, Rubén López-Santiago, Martha C. Moreno-Lafont +11 moredoaj +1 more sourceDrug Critical Limits for Urgent Physician Notification
Clinical Pharmacology &Therapeutics, EarlyView.Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost +3 morewiley +1 more source
