Results 61 to 70 of about 32,815 (232)

Pattern of outcome with sertraline, imipramine, and des-venlafaxine in unipolar nonpsychotic depression

Journal of Mental Health and Human Behaviour, 2015
Background: There is a scarcity of research on the temporal sequence of improvement with antidepressants and the differential effect of different antidepressants.
Abhishek Kapoor, Rohit Garg, Bir Singh Chavan, Paramleen Kaur   +3 more
doaj   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Additive effects of trans-resveratrol and imipramine to reduce depressive symptoms in the forced swimming test in mice

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Resveratrol is a phenolic herbal compound which has been proposed as antioxidant in combinational therapy of diabetes, cancer and some neurodegenerative diseases.
R Ataee, AH Gitinavard, A Ataie, Y Nourian, M Shaterpour   +4 more
doaj  

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Features of reproduction and assisted reproduction in the white (Ceratotherium simum) and black (Diceros bicornis) rhinoceros [PDF]

, 2015
Despite the worldwide increase of rhinoceros calf numbers, the growth of the population of white and black rhinoceros is slowing down mainly due to anthropogenic causes, such as poaching and habitat loss.
Govaere, Jan, Van Soom, Ann, van Zijl Langhout, M, Ververs, Cyrillus   +3 more
core  

In vivo and in vitro effect of imipramine and fluoxetine on Na+,K+-ATPase activity in synaptic plasma membranes from the cerebral cortex of rats

Brazilian Journal of Medical and Biological Research, 2001
The effects of in vivo chronic treatment and in vitro addition of imipramine, a tricyclic antidepressant, or fluoxetine, a selective serotonin reuptake inhibitor, on the cortical membrane-bound Na+,K+-ATPase activity were studied.
L.M. Zanatta, F.C. Nascimento, S.V.T. Barros, G.R.R.S. Silva, A.I. Zugno, C.A. Netto, A.T.S. Wyse   +6 more
doaj   +1 more source

S3 guideline diagnostics and therapy in alopecia areata – Part 2: Therapy, psychosocial and cosmetic support

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary This second part of the S3 guideline on the diagnosis and treatment of alopecia areata (AA), presents key recommendations on topical and systemic therapy, quality of life and support services. The first part of the guideline, published separately, covers the definition and content of epidemiology and diagnosis as well as comorbidities, risk and
Ulrike Blume‐Peytavi, Andria Constantinou, Tsenka Tomova‐Simitchieva, Adrian Tanew, Michael Sticherling, Hermann Girschick, Annika Vogt, Uwe Schwichtenberg, Uwe Gieler, André Märtens, Kerstin Zienert, Claudia Stenders, Ricardo Niklas Werner, Doris Wilborn   +13 more
wiley   +1 more source

Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression [PDF]

, 2017
Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional and cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of and recovery from depression ...
A Mateus-Pinheiro, A Mateus-Pinheiro, A Mateus-Pinheiro, A Sahay, A Surget, A Surget, AD Simons, B Czeh, BS McEwen, C Schmidt-Hieber, C Yang, EY Fenton, F Hardeveld, G Dagyte, GS Kirshenbaum, J Fuss, J Fuss, JL Onksen, JM Bessa, JM Bessa, JM Bessa, JY Kim, K McAlonan, K Sim, KG Akers, L Clark, L Santarelli, L Suo, MA Kheirbek, MN Jayatissa, N Kee, N Toni, P Patricio, P Willner, R Bisaz, RJ Baldessarini, RJ Boland, S Ge, SD Hollon, SM Southwick, SW Chan, TD Schmittgen, TI Mueller, YF Li, YH Hsiao, YI Sheline   +45 more
core   +1 more source

Anticholinergic Medication Burden Scales: A Systematic Review

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Anticholinergic burden refers to the cumulative anticholinergic effect of all medications taken by an individual. Anticholinergic burden scales help identify patients at risk of anticholinergic adverse effects and guide prescribing. However, substantial variation exists between scales, with no gold standard identified.
Orla Vennard, Carrie Stewart, Mansi Tolia, Roy L. Soiza, Phyo K. Myint   +4 more
wiley   +1 more source

Short-Course Treatment With Imipramine Entrapped in Squalene Liposomes Results in Sterile Cure of Experimental Visceral Leishmaniasis Induced by Antimony Resistant Leishmania donovani With Increased Efficacy

Frontiers in Cellular and Infection Microbiology, 2020
Previously we have shown that long term oral treatment of tricyclic-antidepressant-drug, imipramine, against experimental visceral leishmaniasis, results in clearance of organ parasites, regardless of input infection, either with antimony-sensitive (SbS)
Sandip Mukherjee, Supratim Pradhan, Souradeepa Ghosh, Shyam Sundar, Shantanabha Das, Budhaditya Mukherjee, Budhaditya Mukherjee, Syamal Roy, Syamal Roy   +8 more
doaj   +1 more source