Results 51 to 60 of about 20,494 (215)

Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Understanding the differences in treatment response between subtypes of major depressive disorder (MDD) may help to prevent lengthy trial‐and‐error processes by identifying effective treatment options. The aim of the study was to investigate the impact of atypical features of MDD (MDD‐A) on the response to lithium augmentation (LA)
Hannah Buchbauer, Mazda Adli, Peter Schlattmann, Maximilian Berger, Tom Bschor, Thomas Stamm, Joachim Behr, Roland Ricken, Pichit Buspavanich   +8 more
wiley   +1 more source

Imipramine

Reactions Weekly
Purpose/Background: Although combined plasma levels of imipramine and its metabolite desipramine are routinely assessed during therapeutic drug monitoring (TDM) of imipramine treatment, individual plasma levels are often overlooked. Imipramine and desipramine differ in their pharmacokinetic properties.
Roan Y.N. Kasanmonadi, Astrid M. Kamperman, Birgit C.P. Koch, Tom K. Birkenhager   +3 more
  +4 more sources

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Narcolepsy and rapid eye movement sleep

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini, Lucie Barateau, Fabio Pizza, Giuseppe Plazzi, Yves Dauvilliers   +4 more
wiley   +1 more source

Looking for trouble: A common threat‐detection mechanism underlying pain, fear, and anxiety

Mind &Language, EarlyView.
I put forward a novel cognitive architecture for pain, fear, and anxiety, according to which these three capacities are underpinned by a common threat‐detection mechanism. This mechanism takes information about potential threats as input, assesses whether the threat is actual and, if it deems it is, outputs a threat representation.
Luca Barlassina
wiley   +1 more source

Imipramine decreases oesophageal pain perception in human male volunteers

, 1998
Background—Visceral hyperalgesia is a hallmark of functional gastrointestinal disorders. Antidepressants improve symptoms in these patients, although their mode of action is unclear.
P O Katz, D O Castell, P L Peghini
core   +1 more source

Imipramine pharmacokinetics in depressed geriatric patients

, 1990
Pharmacokinetics of single dose (25 mg i.m.) of imipramine was studied in geriatric and young adult patients with mood disorders requiring antidepressant treatment.
BARALDO, Massimo, FURLANUT, Mario, Zara, G, Benetello, P   +3 more
core   +1 more source

Incontinência do choro e infarto protuberancial unilateral Incontinence of crying and unilateral pontine infarct

Arquivos de Neuro-Psiquiatria, 1995
O presente estudo trata do caso de um paciente que apresentou incontinência do choro e hemiplegia direita por infarto ventroprotuberancial paramediano detectado pela RNM.
Ricardo de Oliveira-Souza, Wagner Martignoni de Figueiredo, Pedro ângelo Andreiuolo   +2 more
doaj   +1 more source

Platelet‐activating factor‐receptor signaling mediates solar‐simulated light‐induced extracellular vesicle release in human keratinocytes

Photochemistry and Photobiology, EarlyView.
Solar‐simulated light (SSL) promotes extracellular vesicle (EV) release from keratinocytes through a UVB‐driven, oxidative stress‐dependent pathway. SSL‐induced reactive oxygen species (ROS) generate oxidized glycerophosphocholines with PAF agonistic activity, which activate the Platelet‐activating factor receptor (PAFR), leading to acid ...
Divyanshu Aggarwal, Anita Thyagarajan, Michael G. Kemp, Ravi P. Sahu   +3 more
wiley   +1 more source

Estudo do efeito neuroprotetor da mirtazapina e imipramina e sua relação com a expressão gênica de proteínas apoptóticas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foram investigados a ação neuroprotetora dos antidepressivos mirtazapina e imipramina e os efeitos ...
Lieberknecht, Vicente
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