Results 71 to 80 of about 32,815 (232)
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker +9 more
wiley +1 more source
PaperRobot: Incremental Draft Generation of Scientific Ideas
, 2019 We present a PaperRobot who performs as an automatic research assistant by (1) conducting deep understanding of a large collection of human-written papers in a target domain and constructing comprehensive background knowledge graphs (KGs); (2) creating ...
Bansal, Mohit +6 more
core +1 more source
Experimental Evidence for the Involvement of PDLIM5 in Mood Disorders in Hetero Knockout Mice [PDF]
, 2013 BackgroundReports indicate that PDLIM5 is involved in mood disorders. The PDLIM5 (PDZ and LIM domain 5) gene has been genetically associated with mood disorders; it’s expression is upregulated in the postmortem brains of patients with bipolar disorder ...
Arinami Tadao +8 more
core +1 more source
Narcolepsy and rapid eye movement sleep
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Since the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive ...
Francesco Biscarini +4 more
wiley +1 more source
The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]
, 2011 Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman +8 more
core +1 more source
Research and Reports in Urology, 2019 Thomson T Tai,1,2 Brent T Tai,2,3 Yu-Jun Chang,2 Kuo-Hsuan Huang4,5 1Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA; 2Department of Epidemiology and Biostatistics, Changhua Christian Hospital, Changhua, Taiwan; 3Burrell College ...
Tai TT, Tai BT, Chang YJ, Huang KH
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Photochemistry and Photobiology, EarlyView.Photodynamic therapy (PDT) is a nonscarring treatment modality that is widely used for skin cancers and early squamous precursor lesions. PDT was previously thought to work primarily by killing cancer cells directly (via apoptosis or necrosis). However, more recent work indicates that a significant mechanism for PDT is the stimulation of anti‐cancer ...
Mark P. Ortenzio +4 more
wiley +1 more source
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis [PDF]
, 2013 Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs.
Almeida, O. F. X. +8 more
core +1 more source
Photochemistry and Photobiology, EarlyView.In this model, ROS generated by UVB result in PAFR agonists acting upon the PAFR resulting in MVP generation release via the enzyme aSMase. In photosensitivity, there are increased ROS, resulting in augmented PAF agonists and increased MVP release. This process can be blocked by aSMase inhibitors.
Risha Annamraju +13 more
wiley +1 more source
Alprazolam for depression [PDF]
, 2012 BACKGROUND: The 'off-label' effect of alprazolam on depression has not been systematically evaluated.OBJECTIVES: To determine the antidepressant effect, including tolerability and acceptability, of alprazolam as monotherapy for major depression, when ...
Aden +76 more
core +2 more sources