Results 71 to 80 of about 18,821 (217)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Imipramine pharmacokinetics in depressed geriatric patients

, 1990
Pharmacokinetics of single dose (25 mg i.m.) of imipramine was studied in geriatric and young adult patients with mood disorders requiring antidepressant treatment.
BARALDO, Massimo, FURLANUT, Mario, Zara, G, Benetello, P   +3 more
core  

Imipramine-Induced Facial Pigmentation: Case Report and Literature Review

, 2005
Background: Patients who present with facial pigmentation can be a diagnostic challenge. ObjectiveThe goal of this study was to discuss the diagnosis and management of imipramine-induced facial pigmentation.
Gia-Khanh Nguyen, Andrei I. Metelitsa, Andrew N. Lin   +2 more
core   +1 more source

Effect of Local and Application of Amitriptyline and Imipramine on Teeth with Irreversible Pulpitis Failed Pulpal Anesthesia: A Randomized, Double-blind, Controlled Trial

Dental Hypotheses, 2016
Introduction: To evaluate the analgesic effect of amitriptyline and imipramine after local application on the dentine of “hot teeth” with failed pulpal anesthesia.
Mohsen Aminsobhani, Naghmeh Meraji, Abdollah Ghorbanzadeh, Majid Ajami, Seied Ali Seiedi Hoseini, Mohammad J Kharazifard   +5 more
doaj   +1 more source

Gastroenterological Society of Australia Position Statement on the Assessment and Management of Idiopathic Gastroparesis

Journal of Gastroenterology and Hepatology, Volume 41, Issue 7, Page 2043-2061, July 2026.
The first Australian guidance document on the assessment and management of idiopathic gastroparesis (IGP) reconceptualises IGP as a sensorimotor disorder. It proposes a novel multidisciplinary treatment algorithm and 20 high‐consensus recommendations, addressing common overlapping disorders, and providing clear guidance on associated disordered eating ...
Trina Kellar, Chamara Basnayake, Jessica Biesiekierski, Rebecca Burgell, Jessica Fitzpatrick, Geoffrey Hebbard, Vincent Ho, Hannah Kim, Simon R. Knowles, Christopher K. Rayner, May Wong, Nicholas J. Talley   +11 more
wiley   +1 more source

Studies on ¹⁴C-imipramine Metabolism in the Isolated Perfused Rat Liver

, 1974
An analytical procedure for the measurement of 14C-imipramine and its metabolites in liver, bile, and perfusion fluid has been studied using the isolated perfused rat liver technique. The extraction efficiency and specificity have been found to be high (
G. D. Bellward, Mervin Moldowan
core   +1 more source

Comparison of Lavandula officinalis tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized pilot study

Journal of Medicinal Plants, 2002
Depression is a major health problem and is not only underrecognized and undertreated but is associated with significant morbidity and mortality. Lavandula officinalis is used to treat depression.
M Khani, H Vazirian, AH Jamshidi, A Kamalipour, L Kashani, S Akhondzadeh   +5 more
doaj  

Effects of Voluntary Imipramine Intake via Food and Water in Paradigms of Anxiety and Depression in naïve Mice

Brain Science Advances, 2016
Objective We sought to investigate the efficacy of oral dosing in mice with imipramine (7mg/kg/day) via water or in food pellets, and to compare its effects in the paradigms of learned helplessness, locomotion, hedonic state, and anxiety.
João Pedro Costa-Nunes, Anastassia Bakhmet, Margarida Araújo-Correia, Andreia Barbosa Valença, Tatyana Strekalova, Harry W. M. Steinbusch   +5 more
doaj   +1 more source

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta‐Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Understanding the congruent effects of different types of antidepressant treatments on sensitive brain regions, such as the hippocampus and cortex, can highlight essential mechanisms of action. We used a systematic meta‐analysis of public transcriptional profiling datasets to identify genes and functional gene sets that are differentially expressed ...
Eva M. Geoghegan, Megan H. Hagenauer, Erin Hernandez, Sophia Espinoza, Elizabeth I. Flandreau, Phi T. Nguyen, Adrienne N. Santiago, Mubashshir Ra’eed Bhuiyan, Sophie Mensch, Stanley J. Watson Jr., Huda Akil, René Hen   +11 more
wiley   +1 more source

A truly knotless technique for scleral fixation of intraocular lenses: Two-year results

Indian Journal of Ophthalmology, 2012
Scleral fixated intraocular lens (SFIOL) is a safe and effective option for managing optical aphakia. Suture related complications like suture erosion, suture breakage, endophthalmitis, etc. are unique to SFIOL.
Naresh K Yadav, Vasudha Kemmanu, Mayuri Bhargava, Bhujanga Shetty   +3 more
doaj   +1 more source