Results 161 to 170 of about 56,664 (214)
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Tricyclic Neovibsanin Scaffold (TCNS) as an Effective Antidepressant Agent
Drug Research, 2015Neovibsanin type natural products were found to display neurite outgrowth activity in PC12 cells. This suggests that such type of compounds could be promising candidates for the development of novel therapeutic agents to treat neurological diseases.
M.-Q. Tang, G.-L. Mi, D.-D. Qiao
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Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents
Annals of Allergy, Asthma & Immunology, 2006Aromatic anticonvulsant agents such as carbamazepine and phenytoin can induce anticonvulsant hypersensitivity syndrome (AHS) at a frequency of 1 in 10,000 to 1 in 1,000 treated patients. The hypersensitivity syndrome is a potentially life-threatening adverse drug reaction with multiorgan involvement, and incidental reexposure must be strictly avoided ...
Eva B. Bröcker +4 more
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Journal of Toxicology: Clinical Toxicology, 1982
The IV infusion of nortriptyline and amitriptyline (0.5 mg/kg/min) in anesthetized cats produced death within 60 min of continuous infusion. The tricyclic antidepressant agents produced a quinidine-like depression of the myocardium characterized by bradycardia, depression of contractile force, conduction defects, bradyarrhythmias, and hypotension.
Christopher H. Follmer +3 more
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The IV infusion of nortriptyline and amitriptyline (0.5 mg/kg/min) in anesthetized cats produced death within 60 min of continuous infusion. The tricyclic antidepressant agents produced a quinidine-like depression of the myocardium characterized by bradycardia, depression of contractile force, conduction defects, bradyarrhythmias, and hypotension.
Christopher H. Follmer +3 more
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Prostaglandins, 1977
Clomipramine inhibited pressor responses to potassium ions and vasopressin in the rat mesenteric vascular bed with an ID50 of about 1.8 microgram/ml against both pressor agents and the actions of indomethacin and PG2 on the clomipramine effect suggested that the drug may have been antagonising the action of an endogenous PG.
David F. Horrobin +2 more
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Clomipramine inhibited pressor responses to potassium ions and vasopressin in the rat mesenteric vascular bed with an ID50 of about 1.8 microgram/ml against both pressor agents and the actions of indomethacin and PG2 on the clomipramine effect suggested that the drug may have been antagonising the action of an endogenous PG.
David F. Horrobin +2 more
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Journal of Clinical Psychopharmacology, 1990
In this review, the physiologic and pharmacologic effects of tricyclic antidepressants are discussed as they apply to an overdose situation. Systemic arterial hypotension is a frequent occurrence in major overdoses. Occasionally conventional resuscitative measures such as crystalloid or colloid infusion are inadequate and vasoactive agents must be ...
Alan L. Buchman +2 more
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In this review, the physiologic and pharmacologic effects of tricyclic antidepressants are discussed as they apply to an overdose situation. Systemic arterial hypotension is a frequent occurrence in major overdoses. Occasionally conventional resuscitative measures such as crystalloid or colloid infusion are inadequate and vasoactive agents must be ...
Alan L. Buchman +2 more
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Who are the nonresponders to standard treatment with tricyclic antidepressant agents for cyclic vomiting syndrome in adults? [PDF]
Alimentary Pharmacology & Therapeutics, 2009 SummaryBackground Cyclic vomiting syndrome in adults is a disorder characterized by recurrent and stereotypic episodes of severe nausea and vomiting separated by symptom‐free periods.Aims To investigate the demographic and clinical characteristics of adult cyclic vomiting syndrome patients not responding to standard tricyclic antidepressant (TCA ...
Reza Hejazi +4 more
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Antidepressants II: tricyclic agents
2002Abstract Tricyclic antidepressants (TCA) were first synthesized in the 1940s by chemists looking for drugs to act as sedatives, antihistamines, and anti-parkinsonian drugs (Baldessarini, 1996). Use in depression was first reported in the late 1950s, and hundreds of studies have confirmed their effectiveness in adult populations.
Karl Gundersen, Barbara Geller
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Combined intoxication with tricyclic antidepressive and neuroleptic agents.
1996We report the case of a patient who co-ingested a tricyclic antidepressant (2500 mg of doxepin) and a neuroleptic drug (3500 mg of prothipendyl). Following overdose either agent can affect the central nervous and cardiovascular systems, inducing arrhythmias, conduction disturbances and hypotension.
Diltoer, Marc +4 more
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Is a Tricyclic Antidepressant the Best First-Line Agent in Treating Neuropathic Pain?
2017Neuropathic pain can burden patients in multiple domains and remains a challenge to treat. The success in the treatment of neuropathic pain depends on evidence-based medicine and individualized patient care.
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