Results 11 to 20 of about 10,009 (73)

The Global Landscape of Neuropsychiatric Prescribing Practices of Nurses: A Scoping Review

open access: yesInternational Journal of Mental Health Nursing, Volume 34, Issue 4, July 2025.
ABSTRACT Mental healthcare service access in South Africa is currently strained due to, among others, shortages of specialised mental healthcare professionals. The National Strategic Plan for HIV, TB and STIs (2023‐2028) recommends enabling nurses to diagnose, prescribe and dispense neuropsychiatric medication for promoting mental health services.
M. Naidoo, C. J. Filmalter, W. Cordier
wiley   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

open access: yesMedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes   +4 more
wiley   +1 more source

Pharmacological Treatment of Neuropsychiatric Symptoms in Huntington's Disease: A Systematic Review

open access: yesMovement Disorders Clinical Practice, Volume 12, Issue 4, Page 418-431, April 2025.
ABSTRACT Background Studies focusing on the treatment of neuropsychiatric symptoms (NPS) in Huntington's disease (HD) are scarce and show a wide variation in design, outcome measures and methodological quality. The effectiveness of pharmacological treatment of NPS in HD has not been systematically reviewed so far.
Ruben L. Andriessen   +5 more
wiley   +1 more source

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

open access: yesOrthopaedic Surgery, Volume 17, Issue 3, Page 922-938, March 2025.
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Hao Li   +7 more
wiley   +1 more source

Contribution of physiological dynamics in predicting major depressive disorder severity

open access: yesPsychophysiology, Volume 62, Issue 2, February 2025.
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès   +11 more
wiley   +1 more source

Use of Hemoadsorption and Continuous Venovenous Hemodialysis With Enhanced Middle Molecule Clearance in Drug‐Induced Rhabdomyolysis

open access: yesCase Reports in Critical Care, Volume 2025, Issue 1, 2025.
Drug‐induced rhabdomyolysis has become increasingly prevalent due to the rising use of medications such as statins, antidepressants, and antipsychotics. These can lead to muscle cell destruction and the release of myoglobin, potentially causing kidney damage.
Sebastian Hafner   +5 more
wiley   +1 more source

Efficacy and safety of antidepressants for pain in older adults: A systematic review and meta‐analysis

open access: yesBritish Journal of Clinical Pharmacology, Volume 90, Issue 12, Page 3097-3118, December 2024.
Aims In many countries, pain is the most common indication for use of antidepressants in older adults. We reviewed the evidence from randomized controlled trials on the efficacy and safety of antidepressants, compared to all alternatives for pain in older adults (aged ≥65 years).
Sujita W. Narayan   +10 more
wiley   +1 more source

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han   +5 more
wiley   +1 more source

A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent‐related confounding by indication

open access: yesActa Psychiatrica Scandinavica, Volume 150, Issue 4, Page 198-208, October 2024.
Abstract Background The comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) has been subjected to relatively little research. However, a recent study based on target trial emulation suggested that sertraline may be more effective than escitalopram.
Christopher Rohde   +2 more
wiley   +1 more source

Antidepressant prescribing in Australian primary care: time to reevaluate

open access: yes
Medical Journal of Australia, Volume 222, Issue 9, Page 430-432, May 2025.
Katharine A Wallis   +2 more
wiley   +1 more source

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