Results 11 to 20 of about 10,863 (191)

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis. [PDF]

Orthop Surg
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Li H, Yang Y, Li B, Yang J, Liu P, Gao Y, Zhang M, Ning G.   +7 more
europepmc   +2 more sources

Antidepressant prescribing in Australian primary care: time to reevaluate. [PDF]

Med J Aust
Medical Journal of Australia, Volume 222, Issue 9, Page 430-432, May 2025.
Wallis KA, King A, Moncrieff J.
europepmc   +2 more sources

Ferulic acid as a therapeutic agent in depression: Evidence from preclinical studies

CNS Neuroscience &Therapeutics, Volume 29, Issue 9, Page 2397-2412, September 2023., 2023
Abstract Depression is a common but severe mood disorder with a very high prevalence across the general population. Depression is of global concern and poses a threat to human physical and mental health. Ferulic acid (FA) is a natural active ingredient that has antioxidative, anti‐inflammatory, and free radical scavenging properties.
Xiaoyu Dong, Dongxue Zhao
wiley   +1 more source

Lepidium meyenii Walp (Maca)‐derived extracellular vesicles ameliorate depression by promoting 5‐HT synthesis via the modulation of gut–brain axis

iMeta, Volume 2, Issue 3, August 2023., 2023
We successfully isolated Maca‐EVs using ultracentrifugation and tested its antidepressant effects in the unpredictable chronic mild stress mice. Maca‐EVs increased serum serotonin (5‐HT) levels probably via the gut microbiota and metabolism modulation.
Rui Hong, Lan Luo, Liang Wang, Zhao‐Li Hu, Qi‐Rong Yin, Ming Li, Bin Gu, Bin Wang, Tao Zhuang, Xin‐Yue Zhang, Yuan Zhou, Wan Wang, Lin‐Yan Huang, Bing Gu, Su‐Hua Qi   +14 more
wiley   +1 more source

Increased risk of depression after Guillain‐Barré syndrome

Muscle &Nerve, Volume 67, Issue 6, Page 497-505, June 2023., 2023
Abstract Introduction/Aims Guillain‐Barré syndrome (GBS) is a potentially life‐threatening disorder, and some patients may develop subsequent depression related to traumatic stress or permanent loss of motor function. We determined the short‐term (0 to 2 years) and long‐term (>2 years) risk of depression after GBS.
Lotte Sahin Levison, Reimar Wernich Thomsen, Henning Andersen   +2 more
wiley   +1 more source

Novel drug developmental strategies for treatment‐resistant depression

British Journal of Pharmacology, Volume 179, Issue 6, Page 1146-1186, March 2022., 2022
Major depressive disorder is a leading cause of disability worldwide. Because conventional therapies are ineffective in many patients, novel strategies are needed to overcome treatment‐resistant depression (TRD). Limiting factors of successful drug development in the last decades were the lack of (1) knowledge of pathophysiology, (2) translational ...
Éva Borbély, Mária Simon, Eberhard Fuchs, Ove Wiborg, Boldizsár Czéh, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Antidepressant use and stroke or mortality risk in the elderly

European Journal of Neurology, Volume 29, Issue 2, Page 469-477, February 2022., 2022
In real‐world data of the elderly population, it was found that the risk of experiencing stroke or death in antidepressant users during and up to 1 year after exposure was higher compared to non‐users, even after adjustment for possible confounders. Abstract Background and purpose Current evidence on antidepressant‐related stroke or mortality risk is ...
Begüm Irmak Ön, Xavier Vidal, Ursula Berger, Mònica Sabaté, Elena Ballarín, Olga Maisterra, Antonio San‐Jose, Luisa Ibáñez   +7 more
wiley   +1 more source

[Retracted] Affective Antidepressant, Cytotoxic Activities, and Characterization of Phyto‐Assisted Zinc Oxide Nanoparticles Synthesized Using Sanvitalia procumbens Aqueous Extract

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Green synthesis of nanoparticles has emerged as an effective and environmentally friendly method. Therefore, the current investigation is based on the green synthesis of zinc oxide nanoparticles (ZnO‐NPs) using plant extract of Sanvitalia procumbens (S. procumbens) that act as a capping and reducing agent. S.
Yasir Rashid, Fozia, Ijaz Ahmad, Nisar Ahmad, Madeeha Aslam, Amal Alotaibi, Shahid Ali Shah   +6 more
wiley   +1 more source

[Retracted] Total Saikosaponins Attenuates Depression‐Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats by Regulating the PI3K/AKT/NF‐κB Signaling Axis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. Depression is a major cause of disability and most antidepressant medicines are ineffective owing to their high toxicity and numerous adverse effects. As a result, there is an urgent need to find new effective treatment methods. This paper aims to investigate the effect and mechanism of total saikosaponins (TSS) on depression‐like behaviors
Zhicong Zhou, Hui Chen, Xiaoyan Tang, Binghong He, Lingxia Gu, Huancun Feng, Muhammad Zia-Ul-Haq   +6 more
wiley   +1 more source

Effects of somatic treatments on suicidal ideation and completed suicides

Brain and Behavior, Volume 11, Issue 11, November 2021., 2021
Abstract Objective This work was undertaken to define and characterize the role of currently available somatic treatments in psychiatry in either increasing or reducing the risk for suicide. Methods Members of the Suicide Prevention Task Group of the National Network of Depression Centers performed a literature review of somatic treatments known to ...
Elise M Hawkins, William Coryell, Stephen Leung, Sagar V. Parikh, Cody Weston, Paul Nestadt, John I. Nurnberger Jr., Adam Kaplin, Anupama Kumar, Ali A. Farooqui, Rif S. El‐Mallakh, For the National Network of Depression Centers Suicide Prevention Task Group   +11 more
wiley   +1 more source