Results 11 to 20 of about 56,664 (214)

[Retracted] Total Saikosaponins Attenuates Depression‐Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats by Regulating the PI3K/AKT/NF‐κB Signaling Axis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. Depression is a major cause of disability and most antidepressant medicines are ineffective owing to their high toxicity and numerous adverse effects. As a result, there is an urgent need to find new effective treatment methods. This paper aims to investigate the effect and mechanism of total saikosaponins (TSS) on depression‐like behaviors
Zhicong Zhou, Hui Chen, Xiaoyan Tang, Binghong He, Lingxia Gu, Huancun Feng, Muhammad Zia-Ul-Haq   +6 more
wiley   +1 more source

The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis

International Journal of Environmental Research and Public Health, 2018
Antidepressive agents are one of the fastest-growing classes of prescribed drugs. However, the effects of antidepressive agents on bone density are controversial.
J. U. Schweiger, U. Schweiger, M. Hüppe, K. Kahl, W. Greggersen, K. Jauch-Chara, Eva Fassbinder   +6 more
semanticscholar   +1 more source

Effects of somatic treatments on suicidal ideation and completed suicides

Brain and Behavior, Volume 11, Issue 11, November 2021., 2021
Abstract Objective This work was undertaken to define and characterize the role of currently available somatic treatments in psychiatry in either increasing or reducing the risk for suicide. Methods Members of the Suicide Prevention Task Group of the National Network of Depression Centers performed a literature review of somatic treatments known to ...
Elise M Hawkins, William Coryell, Stephen Leung, Sagar V. Parikh, Cody Weston, Paul Nestadt, John I. Nurnberger Jr., Adam Kaplin, Anupama Kumar, Ali A. Farooqui, Rif S. El‐Mallakh, For the National Network of Depression Centers Suicide Prevention Task Group   +11 more
wiley   +1 more source

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain [PDF]

, 2008
Background Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain
Tyeryar, Kimberly R, Undieh, Ashiwel S, Vongtau, Habiba OU   +2 more
core   +5 more sources

Models of Depression: Unpredictable Chronic Mild Stress in Mice

Current Protocols, Volume 1, Issue 8, August 2021., 2021
Abstract Major depression is a complex psychiatric disorder characterized by affective, cognitive, and physiological impairments that lead to maladaptive behavior. The high lifetime prevalence of this disabling condition, coupled with limitations of existing medications, make necessary the development of improved therapeutics.
Mathieu Nollet
wiley   +1 more source

Pharmacological treatment of depression in people with a primary brain tumour [PDF]

, 2020
Background This is the second updated version of the Cochrane Review published in Issue 3, 2010 and first updated in Issue 5, 2013. People with a primary brain tumour oGen experience depression, for which drug treatment may be prescribed.
Beevers, Z, Boele, F, Hussain, S, Rooney, AG   +3 more
core   +1 more source

Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia

International Journal of Geriatric Psychiatry, Volume 36, Issue 6, Page 917-925, June 2021., 2021
Abstract Objectives We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with Alzheimer's disease (AD) and Lewy body dementia (LBD) over a 5‐year follow‐up.
Miguel Germán Borda, Alberto Jaramillo‐Jimenez, Ragnhild Oesterhus, Jose Manuel Santacruz, Diego Alejandro Tovar‐Rios, Hogne Soennesyn, Carlos Alberto Cano‐Gutierrez, Audun Osland Vik‐Mo, Dag Aarsland   +8 more
wiley   +1 more source

Clinical relevance and treatment possibilities of bipolar rapid cycling [PDF]

, 2002
Bipolar rapid cycling (RC) is defined as 4 or more affective episodes within 1 year. It has been postulated that RC is related to a poor response to lithium, to the same extent as mixed episodes or other atypical symptoms of the illness.
Amann, B., Dittmann, Sandra, Grunze, Heinz, Walden, Jörg   +3 more
core   +1 more source

Effects of essential oils on central nervous system: Focus on mental health

Phytotherapy Research, Volume 35, Issue 2, Page 657-679, February 2021., 2021
Essential oils have been used as remedies since ancient times for the treatment of numerous illnesses on account of their wide range of biological activities. Recent preclinical and clinical studies have shown varying pharmacological responses in the nervous system leading to anxiolytic, antidepressant, sedative, and anticonvulsant effects ...
Lorena R. Lizarraga‐Valderrama
wiley   +1 more source

Hipertensão arterial sistêmica e depressão [PDF]

, 2005
Despite the high prevalence of depression and hypertension, the relationship between the two diseases has received little attention. This paper reviews the epidemiological, pathophysiological, and prognostic aspects of this association, as well as its ...
Azul, João Batista Serro, Lotufo Neto, Francisco, Scalco, Andréia Zavaloni, Scalco, Mônica Zavaloni   +3 more
core   +3 more sources