Results 41 to 50 of about 1,519,564 (181)

Comprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 3, Page 922-938, March 2025.
This study employed transcriptomic analysis and Mendelian randomization to identify diagnostic and therapeutic biomarkers associated with aging‐circadian rhythm in knee osteoarthritis. Further functional and molecular mechanism analyses were conducted to elucidate their roles in knee osteoarthritis, providing a theoretical basis for clinical diagnosis ...
Hao Li, Yuze Yang, Bo Li, Jiaju Yang, Pengyu Liu, Yuanpeng Gao, Min Zhang, Guangzhi Ning   +7 more
wiley   +1 more source

Escitalopram versus other antidepressive agents for depression.

, 2009
BACKGROUND: Although pharmacological and psychological interventions are both effective for major depression, antidepressant drugs remain the mainstay of treatment in primary and secondary care settings.
Churchill, Rachel C, Churchill, R, A. Nakagawa, R. Churchill, Santilli, Claudio, Hugh McGuire, Atsuo Nakagawa, Corrado Barbui, Nakagawa, Atsuo, Cipriani, Andrea, Barbui, C, Furukawa, TA, Rachel Churchill, McGuire, Hugh, Furukawa, Toshi A, Signoretti, A, BARBUI, Corrado, McGuire, H, Toshi A Furukawa, C. Santilli, Claudio Santilli, Nakagawa, A, SIGNORETTI, Alessandra, T. A. Furukawa, Cipriani, A, H. McGuire, Andrea Cipriani, Alessandra Signoretti, Santilli, C   +28 more
core   +1 more source

Contribution of physiological dynamics in predicting major depressive disorder severity

Psychophysiology, Volume 62, Issue 2, February 2025.
Abstract This study aimed to explore the physiological dynamics of cognitive stress in patients with Major Depressive Disorder (MDD) and design a multiparametric model for objectively measuring severity of depression. Physiological signal recordings from 40 MDD patients and 40 healthy controls were collected in a baseline stage, in a stress‐inducing ...
Esther García Pagès, Spyridon Kontaxis, Sara Siddi, Mar Posadas‐de Miguel, Concepción de la Cámara, Maria Luisa Bernal, Thais Castro Ribeiro, Pablo Laguna, Llorenç Badiella, Raquel Bailón, Josep Maria Haro, Jordi Aguiló   +11 more
wiley   +1 more source

A prospective naturalistic study of antidepressant-induced jitteriness/anxiety syndrome

Neuropsychiatric Disease and Treatment, 2014
Tsuyoto Harada, Ken Inada, Kazuo Yamada, Kaoru Sakamoto, Jun Ishigooka Department of Psychiatry, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan Objective: Patients often develop neuropsychiatric symptoms such as anxiety and ...
Harada T, Inada K, Yamada K, Sakamoto K, Ishigooka J   +4 more
doaj  

Use of Hemoadsorption and Continuous Venovenous Hemodialysis With Enhanced Middle Molecule Clearance in Drug‐Induced Rhabdomyolysis

Case Reports in Critical Care, Volume 2025, Issue 1, 2025.
Drug‐induced rhabdomyolysis has become increasingly prevalent due to the rising use of medications such as statins, antidepressants, and antipsychotics. These can lead to muscle cell destruction and the release of myoglobin, potentially causing kidney damage.
Sebastian Hafner, Johannes Reins, Christoph Baader, Florian Balling, Sebastian Eff, Ricardo Jorge Dinis-Oliveira   +5 more
wiley   +1 more source

Efficacy and safety of antidepressants for pain in older adults: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, Volume 90, Issue 12, Page 3097-3118, December 2024.
Aims In many countries, pain is the most common indication for use of antidepressants in older adults. We reviewed the evidence from randomized controlled trials on the efficacy and safety of antidepressants, compared to all alternatives for pain in older adults (aged ≥65 years).
Sujita W. Narayan, Vasi Naganathan, Lisa Vizza, Martin Underwood, Rowena Ivers, Andrew J. McLachlan, Linyi Zhou, Ramnik Singh, Shunyu Tao, Xiao Xi, Christina Abdel Shaheed   +10 more
wiley   +1 more source

Tricyclic antidepressant self poisoning and admission for acute care

, 2011
Self-poisoning by ingestion of antidepressants is a common method of suicide. Although tricyclic antidepressants (TCAs) are no longer the first choice treatment for depression they are still commonly taken in overdose causing poisoning and admission to ...
McNay, Lisa, Marland, Glenn, McCaig, Marie, Snowden, Austyn, Boyd, Gary   +4 more
core   +1 more source

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

CNS Neuroscience &Therapeutics, Volume 30, Issue 12, December 2024.
Rg1 exhibits antidepressant effects through diverse mechanisms, such as anti‐inflammation, synaptic protection, neurogenesis promotion, brain‐derived neurotrophic factor release, enhancement of astrocyte gap junction function, and regulation of hypothalamic–pituitary–adrenal axis and antioxidative stress. Experimental studies validate Rg1's efficacy in
Dong Han, Zheng Zhao, Tinghui Mao, Man Gao, Xue Yang, Yan Gao   +5 more
wiley   +1 more source

A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent‐related confounding by indication

Acta Psychiatrica Scandinavica, Volume 150, Issue 4, Page 198-208, October 2024.
Abstract Background The comparative effectiveness of selective serotonin reuptake inhibitors (SSRIs) has been subjected to relatively little research. However, a recent study based on target trial emulation suggested that sertraline may be more effective than escitalopram.
Christopher Rohde, Fredrik Hieronymus, Søren Dinesen Østergaard   +2 more
wiley   +1 more source

Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum

, 2005
One bi-bicyclic and two bi-tricyclic derivatives of coumarin–benzofuran, phenanthrene–phenanthrene and phenanthrene–phenanthraquinone, along with seven known compounds, were isolated from stems of Dendrobium thyrsiflorum Rchb.f. (Orchidaceae).
Zhang, G.N., Zhong, L.Y., Guo, Y.L., Zhang, M., Wang, Z., Xu, L., Bligh, S.W.A., Zhang, C.-F.   +7 more
core   +1 more source