Results 71 to 80 of about 16,390 (226)

Assessment of the 3-substituted thietane-1,1-dioxide derivative antidepressant effect using rat model of depression induced by reserpine

Research Results in Pharmacology
Introduction: 3-ethoxythietane-1,1-dioxide (3ETD) is a novel molecule that has demonstrated significant antidepressant properties when administered intraperitoneally (i.p.) to mice once or repeatedly.
Irina L. Nikitina, Gulnara G. Gaisina, Elena E. Klen, Lyubov A. Tkachenko   +3 more
doaj   +1 more source

Antidepressants in Spine Surgery: A Systematic Review to Determine Benefits and Risks [PDF]

Asian Spine Journal, 2019
Antidepressant drugs can be advantageous in treating psychiatric and non-psychiatric illnesses, including spinal disorders. However, spine surgeons remain unfamiliar with the advantages and disadvantages of the use of antidepressant drugs as a part of ...
Ahmed B. Bayoumi, Oyku Ikizgul, Ceren Nur Karaali, Selma Bozkurt, Deniz Konya, Zafer Orkun Toktas   +5 more
doaj   +1 more source

Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]

, 2018
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V, Burbach, Kyle F, Cameron, Lindsay P, Dennis, Megan Y, Duim, Whitney C, Gray, John A, Greb, Alexandra C, Ly, Calvin, McAllister, A Kimberley, Olson, David E, Ori-McKenney, Kassandra M, Paddy, Michael R, Soltanzadeh Zarandi, Sina, Sood, Alexander, Wilson, Paige C, Wong, Jonathan M   +15 more
core   +2 more sources

Sarcopenic Obesity Phenotype Index (SOPi): A Population‐Based Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of SO are essential for preventive interventions and management strategies.
Elizabeth Benz, Alexandre Pinel, Christelle Guillet, Frederic Capel, Bruno Pereira, Dimitris Rizopoulos, Alfonso J. Cruz‐Jentoft, Doris Eglseer, Eva Topinkova, Rocco Barazzoni, Lorenzo M. Donini, Fernando Rivadeneira, Marinka Steur, Trudy Voortman, Peter J. M. Weijs, Josje D. Schoufour, Yves Boirie   +16 more
wiley   +1 more source

The Predominant Protective Effect of Tianeptine Over Other Antidepressants in Models of Neuronal Apoptosis: The Effect Blocked by Inhibitors of MAPK/ERK1/2 and PI3-K/Akt Pathways [PDF]

, 2013
Tianeptine (Tian) possesses neuroprotective potential, however, little is known about the effect of this drug in models of neuronal apoptosis. In the present study, we aimed (1) to compare the neuroprotective capacities of some antidepressants (ADs) in ...
D. Jantas, S. Krawczyk, W. Lason
core   +1 more source

High Prevalence of Psychological Symptoms, Sexual Dysfunction, and Prolonged Medical Leave Two Years After Acute Leukemia Diagnosis—Patient Reported Outcome in Sweden

eJHaem, Volume 6, Issue 5, October 2025.
ABSTRACT Introduction With the purpose of identifying unmet needs of patients with acute leukemia, survivors were identified from the Swedish National Acute Leukemia registries. Methods At six months and at two years from diagnosis, patients were requested by mail to report outcome with focus on depression, sick leave, and sexual dysfunction.
Emma Bergfelt Lennmyr, Anna Lübking, Marie Abrahamsson, Gunnar Juliusson, Martin Höglund, Heléne Hallböök   +5 more
wiley   +1 more source

Antidepressant use and the components of the frailty syndrome

Revista Brasileira de Geriatria e Gerontologia, 2018
Objective: to evaluate the effects of antidepressant use on components of frailty. Methods: a cross-sectional and analytical study comparing groups of users and non-users of antidepressants was carried out in a municipal region in the south of Brazil ...
Vanessa Adelina Casali Bandeira, Evelise Moraes Berlezi, Carolina Baldissera Gross, Christiane de Fátima Colet   +3 more
doaj   +2 more sources

Lithium Augmentation in Treatment‐Resistant Depression: A Qualitative Review of the Literature

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 10, Page 688-701, October 2025.
ABSTRACT Depression is the leading cause of disability worldwide, affecting people of all ages. Both pharmacological and non‐pharmacological therapies are available for its treatment. However, some patients do not respond to first‐line pharmacological interventions, referred to as treatment‐resistant depression (TRD).
Angela Acero‐González, Yahira Guzman, Nadia Juliana Proaños, Rosa‐Helena Bustos, María Aconcha, Ivan Guerrero, Laura Alejandra Martinez, Michael Berk, Seetal Dodd   +8 more
wiley   +1 more source

The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.
ABSTRACT This scoping review investigates the association between ABCB1 polymorphisms and antidepressant efficacy in humans. A systematic search identified 630 records, of which 58 met the inclusion criteria, resulting in 42 unique studies (five randomised controlled trials (RCTs), two randomised studies (non‐RCTs), 30 prospective cohort studies, three
Sofie Voss Thorsen, Cille Bülow, Kim Dalhoff, David Peick Sonne   +3 more
wiley   +1 more source

Effect of Unrestricted Access to Running Wheels on Cancer-Related Fatigue [PDF]

, 2011
Cancer-related fatigue (CRF) occurs in 60-90% of cancer patients and significantly reduces functional status. Tumor growth causes significant wasting of skeletal muscle, thought to be a major factor in CRF.
Little, Courtney
core