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Metabolically Programmed Polyamine Analogue Antidiarrheals

Journal of Medicinal Chemistry, 1996
The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
Raymond J Bergeron   +2 more
exaly   +3 more sources

Antidiarrheal Effects of Dihydroergotamine

The Journal of Clinical Pharmacology, 1977
Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
F, Lechin   +3 more
openaire   +2 more sources

Antidiarrheal therapy

Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
openaire   +2 more sources

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