Results 101 to 110 of about 1,672 (158)
Advances in TROP2-targeted antibody-drug conjugates for breast cancer therapy: into the new era. [PDF]
Jiang K, Wang S.
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<i>Candida dubliniensis</i> as a Cause of Chronic Meningitis in a 3-Year-Old Boy with Acute Lymphoblastic Leukemia. [PDF]
Ćwiertnia A, Chuchla L, Ociepa T.
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Effects of <i>in vitro</i> fermentation of <i>Astragalus</i> polysaccharide on gut microbiota and neurotransmitter metabolites in patients with major depressive disorder. [PDF]
Lin C +9 more
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Artificial Intelligence-Guided Personalized Gut Microbiome Modulation for Persistent Secondary Gastrointestinal Symptoms in Oncology Patients: Clinical Efficacy and Biological Correlates from a Prospective Validation Study. [PDF]
Dragomir RD +11 more
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Metabolically Programmed Polyamine Analogue Antidiarrheals
Journal of Medicinal Chemistry, 1996The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
Raymond J Bergeron +2 more
exaly +3 more sources
Antidiarrheal Effects of Dihydroergotamine
The Journal of Clinical Pharmacology, 1977Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
F, Lechin +3 more
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Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
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Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
openaire +2 more sources

