Results 1 to 10 of about 16,722 (204)

Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and ...
Zhu Zhou, Garrett R. Ainslie, Mengyao Li, Jean Dinh, Maciej J. Zamek‐Gliszczynski, Ping Zhao, Mary F. Paine   +6 more
doaj   +2 more sources

Loperamide poisoning resulting in death: a case report and literature review [PDF]

Frontiers in Pharmacology
Loperamide is a medication commonly used to treat acute and chronic diarrhea and is generally considered safe because it poorly crosses the blood-brain barrier at therapeutic doses. However, in recent years, with the abuse and overdose of loperamide, its
Bowen Wang, Zhan Zhang, Ke Chen, Zhongyang Du, Tianchen Zhang, Ping Xie   +5 more
doaj   +2 more sources

Evaluation of the pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib in healthy volunteers [PDF]

Frontiers in Pharmacology
AimsTo investigate the potential pharmacokinetic interactions of montmorillonite powder or loperamide on pyrotinib.MethodsThis study was a single-center, open-label, single-dose, fixed-sequence clinical trial conducted with healthy volunteers.
Yike Wang, Dai Li, Dai Li, Tong Zhang, Sumei Xu, Sumei Xu, Yanxin Zhang, Yanxin Zhang, Kaijing Zhao, Shaorong Li, Kai Shen, Xiaomin Li, Xiaomin Li, Pingsheng Xu, Pingsheng Xu   +14 more
doaj   +2 more sources

Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus

Viruses, 2021
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia.
Shuzo Urata, Jiro Yasuda, Masaharu Iwasaki   +2 more
doaj   +1 more source

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose

Biomolecules, 2023
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported.
Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher   +7 more
doaj   +1 more source

Loperamide Overdose [PDF]

Cureus, 2019
In light of the opioid epidemic, cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department (ED). Here, we present the case of a 35-year-old male with long QT syndrome who presented following a loperamide overdose and was receiving multiple shocks because of the resulting arrhythmias ...
Arnold, Casey, Martinez Martinez, Carmen J   +1 more
openaire   +2 more sources

A Heart-Wrenching Case of Loperamide Toxicity [PDF]

Asia Pacific Journal of Medical Toxicology, 2019
Background: Loperamide is an insoluble meperidine analog that is commonly used for diarrhea. It is an inexpensive and frequently available over the counter drug.
Sadaf Sheikh, Muhammad Akbar Baig
doaj   +1 more source

Case Report: Opioid Use Disorder Associated With Low/Moderate Dose of Loperamide in an Intellectual Disability Patient With CYP3A and P-Glycoprotein Reduced Activity

Frontiers in Psychiatry, 2022
Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without ...
Vincent Guinchat, Nicolas Ansermot, Kuntheavy Ing Lorenzini, Dimitri Politis, Youssef Daali, Chin B. Eap, Chin B. Eap, Chin B. Eap, Chin B. Eap, Séverine Crettol   +9 more
doaj   +1 more source

Quantitative analysis of Loperamide hydrochloride in the presence its acid degradation products [PDF]

Hemijska Industrija, 2009
The aim of this work was to develop a new RP-HPLC method for the determination of loperamide hydrochloride in the presence of its acid degradation products.
Savić Ivana M., Nikolić Goran S., Savić Ivan M., Marinković Valentina D.   +3 more
doaj   +1 more source

Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers. [PDF]

PLoS ONE, 2012
Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain.
Matthias Ringkamp, Michael Tal, Timothy V Hartke, Matthew Wooten, Alvin McKelvy, Brian P Turnquist, Yun Guan, Richard A Meyer, Srinivasa N Raja   +8 more
doaj   +1 more source