Results 1 to 10 of about 592 (88)

Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus

Viruses, 2021
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia.
Shuzo Urata, Jiro Yasuda, Masaharu Iwasaki   +2 more
doaj   +1 more source

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose

Biomolecules, 2023
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported.
Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher   +7 more
doaj   +1 more source

Quantitative analysis of Loperamide hydrochloride in the presence its acid degradation products [PDF]

Hemijska Industrija, 2009
The aim of this work was to develop a new RP-HPLC method for the determination of loperamide hydrochloride in the presence of its acid degradation products.
Savić Ivana M., Nikolić Goran S., Savić Ivan M., Marinković Valentina D.   +3 more
doaj   +1 more source

Case Report: Opioid Use Disorder Associated With Low/Moderate Dose of Loperamide in an Intellectual Disability Patient With CYP3A and P-Glycoprotein Reduced Activity

Frontiers in Psychiatry, 2022
Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without ...
Vincent Guinchat, Nicolas Ansermot, Kuntheavy Ing Lorenzini, Dimitri Politis, Youssef Daali, Chin B. Eap, Chin B. Eap, Chin B. Eap, Chin B. Eap, Séverine Crettol   +9 more
doaj   +1 more source

A Heart-Wrenching Case of Loperamide Toxicity [PDF]

Asia Pacific Journal of Medical Toxicology, 2019
Background: Loperamide is an insoluble meperidine analog that is commonly used for diarrhea. It is an inexpensive and frequently available over the counter drug.
Sadaf Sheikh, Muhammad Akbar Baig
doaj   +1 more source

Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers. [PDF]

PLoS ONE, 2012
Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain.
Matthias Ringkamp, Michael Tal, Timothy V Hartke, Matthew Wooten, Alvin McKelvy, Brian P Turnquist, Yun Guan, Richard A Meyer, Srinivasa N Raja   +8 more
doaj   +1 more source

Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports. [PDF]

PLoS ONE, 2018
BACKGROUND:Among over-the-counter (OTC) drugs, loperamide has recently emerged for its potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database.
Fabrizio Schifano, Stefania Chiappini
doaj   +1 more source

Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice

Journal of Pharmacological Sciences, 2007
In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki, Yasutaka Nakashima, Ichiro Takasaki, Tsugunobu Andoh, Kimiyasu Shiraki, Yasushi Kuraishi   +5 more
doaj   +1 more source

Alleviation of Abdominal Pain due to Irinotecan-Induced Cholinergic Syndrome Using Loperamide: A Case Report

Case Reports in Oncology, 2021
Irinotecan hydrochloride (irinotecan) is a chemotherapeutic agent used in the treatment of solid tumors. In addition to severe neutropenia and delayed diarrhea, irinotecan causes cholinergic syndrome, characterized by abdominal pain and acute diarrhea ...
Kazuki Uchiyama, Yoshitaka Saito, Yoh Takekuma, Satoshi Yuki, Mitsuru Sugawara   +4 more
doaj   +1 more source

Cytotoxic effects of opiate agonist loperamide hydrochloride on human oral cancer cells—an invitro study [PDF]

Exploration of Medicine
Aim: Loperamide hydrochloride (HCl), a peripheral opioid receptor agonist primarily used as an antidiarrheal drug, has been reported to induce apoptosis in various cancer cell lines.
Chie Ching Tan, Ursula Siau Lan Ting, Zi Xian Khoo, Prashanti Chippagiri, Suan Phaik Khoo, Spoorthi Ravi Banavar   +5 more
doaj   +1 more source