Results 1 to 10 of about 11,037 (196)
Loperamide Inhibits Replication of Severe Fever with Thrombocytopenia Syndrome Virus
Viruses, 2021 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia.
Shuzo Urata +2 more
doaj +3 more sources
Biomolecules, 2023 Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported.
Hua Rong Lu +7 more
doaj +2 more sources
Loperamide Induced Life Threatening Ventricular Arrhythmia [PDF]
Case Reports in Cardiology, 2016 Loperamide is over-the-counter antidiarrheal agent acting on peripherally located μ opioid receptors. It is gaining popularity among drug abusers as opioid substitute. We report a case of a 46-year-old male that was presented after cardiac arrest.
Ankit Upadhyay +6 more
doaj +2 more sources
Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling [PDF]
CPT: Pharmacometrics & Systems PharmacologyLoperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and ...
Zhu Zhou +6 more
doaj +2 more sources
Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
Journal of Pharmacological Sciences, 2007 In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki +5 more
doaj +2 more sources
Loperamide cases reported to United States poison centers, 2010–2022
Injury Epidemiology, 2023 Background Intentional use of high doses of loperamide has been linked to serious cardiac toxicity. The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to ...
Aaditya Patel +7 more
doaj +2 more sources
Novel Insights Into the Association Between Parkinson's Disease and Constipation: Role of SHMT2 as a Promising Biomarker [PDF]
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.This study integrated bioinformatics analysis, cellular models, and PD/constipation mouse models to identify SHMT2 as a key shared biomarker linking Parkinson's disease and constipation. SHMT2 upregulation was validated in dopaminergic neurons and the enteric nervous system, highlighting its potential role in gut–brain axis dysfunction.
Jiehua Su +10 more
wiley +2 more sources
Loperamide poisoning resulting in death: a case report and literature review [PDF]
Frontiers in PharmacologyLoperamide is a medication commonly used to treat acute and chronic diarrhea and is generally considered safe because it poorly crosses the blood-brain barrier at therapeutic doses. However, in recent years, with the abuse and overdose of loperamide, its
Bowen Wang +5 more
doaj +2 more sources
Loperamide Dependence: A Case Report [PDF]
Addiction and Health, 2017 Background: Loperamide is used as an antidiarrheal drug and is available over-the-counter. It cannot pass the blood-brain barrier and it does not have a considerable abuse potential.
Mehran Zarghami, Maryam Rezapour
doaj +1 more source
Cureus, 2019 In light of the opioid epidemic, cardiac complications following a loperamide overdose are a growing concern for patients presenting to the emergency department (ED). Here, we present the case of a 35-year-old male with long QT syndrome who presented following a loperamide overdose and was receiving multiple shocks because of the resulting arrhythmias ...
Arnold, Casey +1 more
openaire +2 more sources