Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports. [PDF]
PLoS ONE, 2018 BACKGROUND:Among over-the-counter (OTC) drugs, loperamide has recently emerged for its potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database.
Fabrizio Schifano, Stefania Chiappini
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Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]
, 1992 Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Auernhammer, Christoph J. +4 more
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Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
Journal of Pharmacological Sciences, 2007 In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki +5 more
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Case Reports in Oncology, 2021 Irinotecan hydrochloride (irinotecan) is a chemotherapeutic agent used in the treatment of solid tumors. In addition to severe neutropenia and delayed diarrhea, irinotecan causes cholinergic syndrome, characterized by abdominal pain and acute diarrhea ...
Kazuki Uchiyama +4 more
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Travelers’ diarrhea and other gastrointestinal symptoms among Boston-area international travelers [PDF]
, 2017 INTRODUCTION: Travelers' diarrhea (TD) and non-TD gastrointestinal (GI) symptoms are common among international travelers. In a study of short-term travelers from Switzerland to developing countries, the most common symptom experienced was severe ...
Barnett, Elizabeth D. +8 more
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Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Microbiome, 2023 Background Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to ...
Rebecca J. Stevick +5 more
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Radiographic evaluation of the effect of diphenoxylate and loperamide on the transit time of the contrast media of gastro-intestinal tract in cat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021 Radiography with contrast media is a diagnostic imaging technique with high-resolution that plays a prominent role in showing the transit time of gastrointestinal system.
Abdolvahed Moarabi +3 more
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Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia
Neurobiology of Pain, 2018 Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats ...
Gong Kerui, Luc Jasmin
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Recent Changes in Drug Abuse Scenario: The Novel Psychoactive Substances (NPS) Phenomenon [PDF]
, 2019 copyright 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are ...
Catalani, Valeria +7 more
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Cytotoxic effects of opiate agonist loperamide hydrochloride on human oral cancer cells—an invitro study [PDF]
Exploration of MedicineAim: Loperamide hydrochloride (HCl), a peripheral opioid receptor agonist primarily used as an antidiarrheal drug, has been reported to induce apoptosis in various cancer cell lines.
Chie Ching Tan +5 more
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