A Heart-Wrenching Case of Loperamide Toxicity [PDF]
Asia Pacific Journal of Medical Toxicology, 2019 Background: Loperamide is an insoluble meperidine analog that is commonly used for diarrhea. It is an inexpensive and frequently available over the counter drug.
Sadaf Sheikh, Muhammad Akbar Baig
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Quantitative analysis of Loperamide hydrochloride in the presence its acid degradation products [PDF]
Hemijska Industrija, 2009 The aim of this work was to develop a new RP-HPLC method for the determination of loperamide hydrochloride in the presence of its acid degradation products.
Savić Ivana M. +3 more
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Frontiers in Psychiatry, 2022 Loperamide is an over-the-counter antidiarrheal for which increasing cases of abuse or misuse are described. We report the onset of opioid use disorder associated with low to moderate doses of loperamide in an intellectual disability patient without ...
Vincent Guinchat +9 more
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Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers. [PDF]
PLoS ONE, 2012 Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain.
Matthias Ringkamp +8 more
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Effects of loperamide on the human hypothalamo-pituitary-adrenal axis in vivo and in vitro. [PDF]
, 1992 Loperamide, an opiate agonist of high specificity for p-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing’s disease. However, there is little information on
Pfeiffer, M. +4 more
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Is there such a thing as a 'lope' dope? Analysis of loperamide-related European Medicines Agency (EMA) pharmacovigilance database reports. [PDF]
PLoS ONE, 2018 BACKGROUND:Among over-the-counter (OTC) drugs, loperamide has recently emerged for its potential of misuse and cardiotoxicity issues. Hence, we aimed here at assessing the loperamide-related cases being reported to the EMA's EudraVigilance (EV) database.
Fabrizio Schifano, Stefania Chiappini
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Case Reports in Oncology, 2021 Irinotecan hydrochloride (irinotecan) is a chemotherapeutic agent used in the treatment of solid tumors. In addition to severe neutropenia and delayed diarrhea, irinotecan causes cholinergic syndrome, characterized by abdominal pain and acute diarrhea ...
Kazuki Uchiyama +4 more
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Radiographic evaluation of the effect of diphenoxylate and loperamide on the transit time of the contrast media of gastro-intestinal tract in cat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021 Radiography with contrast media is a diagnostic imaging technique with high-resolution that plays a prominent role in showing the transit time of gastrointestinal system.
Abdolvahed Moarabi +3 more
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Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Microbiome, 2023 Background Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to ...
Rebecca J. Stevick +5 more
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Cytotoxic effects of opiate agonist loperamide hydrochloride on human oral cancer cells—an invitro study [PDF]
Exploration of MedicineAim: Loperamide hydrochloride (HCl), a peripheral opioid receptor agonist primarily used as an antidiarrheal drug, has been reported to induce apoptosis in various cancer cell lines.
Chie Ching Tan +5 more
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