Results 11 to 20 of about 592 (88)
Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition
Microbiome, 2023 Background Perturbations of animal-associated microbiomes from chemical stress can affect host physiology and health. While dysbiosis induced by antibiotic treatments and disease is well known, chemical, nonantibiotic drugs have recently been shown to ...
Rebecca J. Stevick +5 more
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Radiographic evaluation of the effect of diphenoxylate and loperamide on the transit time of the contrast media of gastro-intestinal tract in cat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021 Radiography with contrast media is a diagnostic imaging technique with high-resolution that plays a prominent role in showing the transit time of gastrointestinal system.
Abdolvahed Moarabi +3 more
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Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia
Neurobiology of Pain, 2018 Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats ...
Gong Kerui, Luc Jasmin
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Loperamide cases reported to United States poison centers, 2010–2022
Injury Epidemiology, 2023 Background Intentional use of high doses of loperamide has been linked to serious cardiac toxicity. The objective of this study is to investigate the characteristics and trends of loperamide cases reported to United States (US) poison centers and to ...
Aaditya Patel +7 more
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‘ Loperamide overdose induces ventricular tachycardia with catastrophic outcomes’
Journal of Community Hospital Internal Medicine Perspectives, 2020 Loperamide is a widely available, over-the-counter medication. The advent of the opioid epidemic has seen cases of loperamide overdose being reported. The common side effects of the medication can be relatively benign, but at high doses, loperamide can ...
Zain Ali +4 more
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Loperamide Induced Life Threatening Ventricular Arrhythmia
Case Reports in Cardiology, 2016 Loperamide is over-the-counter antidiarrheal agent acting on peripherally located μ opioid receptors. It is gaining popularity among drug abusers as opioid substitute. We report a case of a 46-year-old male that was presented after cardiac arrest.
Ankit Upadhyay +6 more
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JAPhA PharmacotherapyBackground: Excessively high doses of loperamide (of up to 792 mg/day) have recently been associated with reports of cardiac events. However, no data currently demonstrate a direct effect of high doses of loperamide on the occurrence of cardiovascular ...
Iolanda Cirillo +3 more
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Journal of Pharmacological Sciences, 2005 The effect of loperamide on tachykinin NK2- and NK3-receptor-mediated 5-HT outflow from guinea pig colonic mucosa was investigated in vitro. The selective tachykinin NK2-receptor agonist [β-Ala8]-neurokinin A4–10 (βAla-NKA) or the selective NK3-receptor ...
Shu-ichi Kojima +2 more
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Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells
Frontiers in Pharmacology, 2023 Introduction: At present, the mu opioid receptor is the most important neuroaesthetics receptor in anesthesiology research, and the damage that it does to the nervous system is unknown.Methods: We investigated the effects of loperamide, an agonist of the
Xutong Zhang +4 more
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A life-threatening ventricular arrhythmia secondary to loperamide abuse, “a poor man’s methadone”
Heart Vessels and Transplantation, 2021 The case of a patient with repetitive syncope episodes with a history of using loperamide at high doses for recreational purposes in search of an effect similar to heroin, is reported.
Miguel A. Rojas Carrera +3 more
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