Results 31 to 40 of about 11,037 (196)

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Loperamide: From antidiarrheal to analgesic

, 2013
Loperamide, an antidiarrheal drug has been observed to produce analgesia in animal models of pain. However, the exact mechanism underlying loperamide analgesia needs further studies.
Rakesh Kumar, MSc, PhD
core   +1 more source

Loperamide-Induced Ventricular Tachycardia Storm

Avicenna Journal of Medicine, 2022
Loperamide is an over-the-counter antilaxative medication with minor opioid properties. For this reason, it has recently become a drug of concern for the Food and Drug Administration due to its potential for abuse.
William Giesing, Cameron Koester, Mohammad Al-Akchar, Abhishek Kulkarni, Mohamed Labedi   +4 more
doaj   +1 more source

Updated ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease 2025

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To revise the 2018 European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies (ERNICA) clinical guideline for the management of rectosigmoid Hirschsprung's disease (HSCR) based on new evidence and evolving clinical priorities, ensuring continued relevance, trustworthiness, and consistency ...
Daniel Rossi, Willemijn Irvine, Anna Löf Granström, Annika Mutanen, Roel Bakx, Kristin Bjørnland, Duccio Cavalieri, Piotr Czauderna, Anne Dariel, Mark Ellebæk, Francesco Fascetti Leon, Fabio Fusaro, Dirk‐Jan Gloudemans, Marietta Jank, Peter Kolja Kvist, Martin Lacher, Annette Lemli, Lucas Matthyssens, Louise Montalva, Pedro Palazon, Alessio Pini Prato, Lucie Pos, Roxana Rassouli‐Kirchmeier, Konrad Reinshagen, Nagoud Schukfeh, Rony Sfeir, Olivia Spivack, Pernilla Stenström, Lovisa Telborn, Eelke Toxopeus, Alejandra Vilanova, Miriam Wilms, Rene Wijnen, Cornelius E. J. Sloots, Mikko Pakarinen, Tomas Wester   +35 more
wiley   +1 more source

Identifying patient‐centered outcomes in progressive familial intrahepatic cholestasis: Results from IMPACT

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives In rare diseases like progressive familial intrahepatic cholestasis (PFIC), lack of evidence results in treatment variability and strategies for families to engage care teams to understand how variability affects overall health are unknown.
James E. Squires, Gitta H. Lubke, Emily Ventura, Alexandra Perez, Paula M. Hertel, Emily R. Perito, Laura Bull, Melissa Kochanowsky   +7 more
wiley   +1 more source

Comparison of the Antisecretory Effects of Loperamide and Loperamide Oxide in the Jejunum and the Colon of Rats In-vivo

, 1990
The antidiarrhoeal effect of loperamide is caused by its antimotility and antisecretory properties. In-vivo experiments in the rat jejunum and colon have been performed to compare the antisecretory effect of loperamide with the effect of its prodrug ...
Eckhard Beubler, Pramila Badhri
core   +1 more source

Prebiotics/Probiotics Mixture Induced Changes in Cecal Microbiome and Intestinal Morphology Alleviated the Loperamide-Induced Constipation in Rat

Food Science of Animal Resources, 2021
The aim of this study was to investigate the effect of a mixture of multi-strain probiotics and prebiotics on loperamide-induced constipation in Sprague-Dawley rats.
Min Guk Kim, Kyungae Jo, Kyoungwon Cho, Sung Sun Park, Hyung Joo Suh, Ki-Bae Hong   +5 more
doaj   +1 more source

Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review

Journal of Cardiovascular Development and Disease, 2022
Loperamide is a synthetic opioid commonly used as an antidiarrheal due to its activation of u-opioid receptors in the myenteric plexus. In therapeutic doses, it inhibits peristalsis and has anti-secretory and anti-motility effects, until metabolized by ...
Bruna Cremonezi Lammoglia, Gabriela Hasselmann, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Fernando Sabia Tallo, Murched Omar Taha, Rildo Yamaguti Lima, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues   +9 more
doaj   +1 more source

Evaluation of the acceptance rate of analgesic stewardship team recommendations at a metropolitan hospital network

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Analgesic stewardship (AGS) programs, a novel concept in Australia, aim to assess and optimise opioid and other analgesia by carrying out medication reviews and providing clinical recommendations to the treating teams. Aim This study aimed to determine the rate and extent of acceptance of AGS team recommendations among adult ...
Hatsumi Kobayashi, Jeremy Szmerling, Sam Maleki, Mahisha Thiruvasagan, Gordon Mar   +4 more
wiley   +1 more source

Ventricular fibrillation due to overdose of loperamide, the “poor man’s methadone”

Journal of Community Hospital Internal Medicine Perspectives, 2017
Loperamide is an over-the-counter antidiarrheal agent that is considered by many patients to be safe, but has been used as a drug of abuse due to its opioid properties.
Amr Salama, Yana Levin, Pramod Jha, Richard Alweis   +3 more
doaj   +1 more source