Results 21 to 30 of about 11,037 (196)
Dual effects of brain sparing opioid in newborn rats: Analgesia and hyperalgesia
Neurobiology of Pain, 2018 Effective pain management in neonates without the unwanted central nervous system (CNS) side effects remains an unmet need. To circumvent these central effects we tested the peripherally acting (brain sparing) opioid agonist loperamide in neonate rats ...
Gong Kerui, Luc Jasmin
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‘ Loperamide overdose induces ventricular tachycardia with catastrophic outcomes’
Journal of Community Hospital Internal Medicine Perspectives, 2020 Loperamide is a widely available, over-the-counter medication. The advent of the opioid epidemic has seen cases of loperamide overdose being reported. The common side effects of the medication can be relatively benign, but at high doses, loperamide can ...
Zain Ali +4 more
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Journal of Pharmacological Sciences, 2005 The effect of loperamide on tachykinin NK2- and NK3-receptor-mediated 5-HT outflow from guinea pig colonic mucosa was investigated in vitro. The selective tachykinin NK2-receptor agonist [β-Ala8]-neurokinin A4–10 (βAla-NKA) or the selective NK3-receptor ...
Shu-ichi Kojima +2 more
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Quantitative proteomic analysis reveals the effects of mu opioid agonists on HT22 cells
Frontiers in Pharmacology, 2023 Introduction: At present, the mu opioid receptor is the most important neuroaesthetics receptor in anesthesiology research, and the damage that it does to the nervous system is unknown.Methods: We investigated the effects of loperamide, an agonist of the
Xutong Zhang +4 more
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A life-threatening ventricular arrhythmia secondary to loperamide abuse, “a poor man’s methadone”
Heart Vessels and Transplantation, 2021 The case of a patient with repetitive syncope episodes with a history of using loperamide at high doses for recreational purposes in search of an effect similar to heroin, is reported.
Miguel A. Rojas Carrera +3 more
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, 1993 Mucosal loperamide inhibited the absorption of glycine by everted sacs of rat small intestine over 10-, 30- or 60-min incubation periods, but loperamide oxide was without effect.
Jacqueline Hardcastle +2 more
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Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose
Clinical Practice and Cases in Emergency Medicine, 2019 Loperamide is an inexpensive, over-the-counter antidiarrheal agent with emerging reports of overdose due to its opioid properties. Although it is considered by many patients to be safe, cardiotoxicity has been reported, prompting the United States Food ...
Kasha Bornstein +2 more
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Comparative Analysis of Quality Requirements for Loperamide Hydrochloride Medicinal Products
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. Loperamide hydrochloride medicinal products are registered in the Russian Federation in the dosage forms of “tablets” and “capsules”. Since the State Pharmacopoeia of the Russian Federation (SP RF) does not include pharmacopoeial articles ...
A. N. Novichenko +3 more
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, 1993 In-vivo experiments in the rat jejunum have been performed to compare the antisecretory effect of orally administered loperamide with the effect of its pro-drug, loperamide oxide.
Eckhard Beubler +2 more
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Cytotoxic effects of loperamide hydrochloride on canine cancer cells. [PDF]
, 2014 Loperamide is a peripheral opiate agonist that can cause apoptosis and G2/M arrest in human cancer cell lines and may sensitize cells to chemotherapy. The objectives of this study were to investigate the effects of loperamide on viability, apoptosis and ...
Gogal, Robert +5 more
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