Results 21 to 30 of about 592 (88)

Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose

Clinical Practice and Cases in Emergency Medicine, 2019
Loperamide is an inexpensive, over-the-counter antidiarrheal agent with emerging reports of overdose due to its opioid properties. Although it is considered by many patients to be safe, cardiotoxicity has been reported, prompting the United States Food ...
Kasha Bornstein, Timothy Montrief, Mehruba Anwar Parris   +2 more
doaj   +1 more source

Managing Drug–Drug Interactions Involving the Non‐Prescription Opioid Loperamide Through Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics & Systems Pharmacology
Loperamide is a widely used nonprescription peripherally acting opioid indicated for diarrhea. Loperamide undergoes extensive first‐pass metabolism, primarily by cytochrome (CYP) 3A and CYP2C8, with minor contributions from CYP2B6 and CYP2D6, and ...
Zhu Zhou, Garrett R. Ainslie, Mengyao Li, Jean Dinh, Maciej J. Zamek‐Gliszczynski, Ping Zhao, Mary F. Paine   +6 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Evaluation of the acceptance rate of analgesic stewardship team recommendations at a metropolitan hospital network

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Analgesic stewardship (AGS) programs, a novel concept in Australia, aim to assess and optimise opioid and other analgesia by carrying out medication reviews and providing clinical recommendations to the treating teams. Aim This study aimed to determine the rate and extent of acceptance of AGS team recommendations among adult ...
Hatsumi Kobayashi, Jeremy Szmerling, Sam Maleki, Mahisha Thiruvasagan, Gordon Mar   +4 more
wiley   +1 more source

Comparative Analysis of Quality Requirements for Loperamide Hydrochloride Medicinal Products

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Loperamide hydrochloride medicinal products are registered in the Russian Federation in the dosage forms of “tablets” and “capsules”. Since the State Pharmacopoeia of the Russian Federation (SP RF) does not include pharmacopoeial articles ...
A. N. Novichenko, E. L. Kovaleva, P. A. Onisko, K. S. Kochetov   +3 more
doaj   +1 more source

Preliminary Comparison of Competitive Efflux and Historical Transwell Assays for Assessing Canine P‐Glycoprotein Substrate Status of Eleven Drugs Representing Ten Different Drug Classes

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Because P‐glycoprotein (P‐gp) influences the disposition of substrate drugs, regulatory agencies recommend ascertaining the P‐gp substrate status of active pharmaceutical ingredients (API's) intended for humans. Transwell‐based assays using P‐gp‐overexpressing human cell lines are routinely used to predict the API's P‐gp substrate status ...
K. L. Mealey, N. S. Burke
wiley   +1 more source

Loperamide-Induced Ventricular Tachycardia Storm

Avicenna Journal of Medicine, 2022
Loperamide is an over-the-counter antilaxative medication with minor opioid properties. For this reason, it has recently become a drug of concern for the Food and Drug Administration due to its potential for abuse.
William Giesing, Cameron Koester, Mohammad Al-Akchar, Abhishek Kulkarni, Mohamed Labedi   +4 more
doaj   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Prebiotics/Probiotics Mixture Induced Changes in Cecal Microbiome and Intestinal Morphology Alleviated the Loperamide-Induced Constipation in Rat

Food Science of Animal Resources, 2021
The aim of this study was to investigate the effect of a mixture of multi-strain probiotics and prebiotics on loperamide-induced constipation in Sprague-Dawley rats.
Min Guk Kim, Kyungae Jo, Kyoungwon Cho, Sung Sun Park, Hyung Joo Suh, Ki-Bae Hong   +5 more
doaj   +1 more source

Risk of Cardiac Lesion with Chronic and Acute Use of Loperamide—An Integrative Review

Journal of Cardiovascular Development and Disease, 2022
Loperamide is a synthetic opioid commonly used as an antidiarrheal due to its activation of u-opioid receptors in the myenteric plexus. In therapeutic doses, it inhibits peristalsis and has anti-secretory and anti-motility effects, until metabolized by ...
Bruna Cremonezi Lammoglia, Gabriela Hasselmann, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Fernando Sabia Tallo, Murched Omar Taha, Rildo Yamaguti Lima, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues   +9 more
doaj   +1 more source