Results 191 to 200 of about 3,411 (219)
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Polyamine Analogue Antidiarrheals: A Structure−Activity Study
Journal of Medicinal Chemistry, 2000The syntheses of a group of spermine polyamine analogues and their evaluation as antidiarrheals are described. Each compound was assessed in a rodent castor oil-induced diarrhea model for its ability to reduce stool output and weight loss in a dose-dependent manner. The spermine pharmacophore is shown to be an excellent platform from which to construct
R J, Bergeron +8 more
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Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors
European Journal of Pharmacology, 1987Thiorphan and acetorphan, two potent inhibitors of enkephalinase (EC 3.4.24.11 membrane-metalloendopeptidase) significantly reduced the castor oil-induced diarrhea in rats when administered intravenously (or orally, for acetorphan) but not when administered intracerebroventricularly. These effects were more marked during the 90 min period following the
H, Marçais-Collado +4 more
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[Antidiarrheal drugs for chronic diarrhea].
Deutsche medizinische Wochenschrift (1946), 2014Chronic diarrhea can be caused by multiple disease entities. Basic diagnostic tests are required in order to administer specific therapies whenever possible. If no specific treatment can be used, a symptomatic management should be initiated in order to prevent massive electrolyte- and water losses.
B, Vohmann, J C, Hoffmann
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Pharmacology of Antidiarrheal Drugs
Annual Review of Pharmacology and Toxicology, 1983F, Awouters +2 more
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Development of New Antidiarrheal Medications
Journal of Clinical Gastroenterology, 1983L E, Rosenthal +2 more
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CI-750, A NOVEL ANTIDIARRHEAL AGENT
The Journal of Pharmacology and Experimental Therapeutics, 1973P, Bass +4 more
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