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Antidiarrheal Drug Therapy [PDF]
Current Gastroenterology Reports, 2017 Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
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Antidiarrheal Effects of Dihydroergotamine
The Journal of Clinical Pharmacology, 1977Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
Fuad Lechin +3 more
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Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.
The Journal of Pharmacology and Experimental Therapeutics, 1979Three synthetic antidiarrheals, diphenoxylate, loperamide and SC 27166, and two narcotics, morphine and codeine, were evaluated in rats by the intravenous and oral route for specificity and duration of their antidiarrheal, opiate-like and acute toxic effects.
C J, Niemegeers +3 more
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MECHANISMS OF ANTIDIARRHEAL EFFECT BY PROBIOTICS
Journal of Pediatric Gastroenterology and Nutrition, 2016Gastroenteritis is a major cause of morbidity and mortality worldwide. Several microbial pathogens cause secretory diarrhea such as Vibrio cholerae and enterotoxigenic Escherichia coli as well as enteric viruses such as Rotavirus (RV) and Norovirus and parasites including Cryptosporidium.
Eliana Ruberto +2 more
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Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
Richard N. Fedorak, Michael E. Field
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Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
Richard N. Fedorak, Michael E. Field
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Metabolically Programmed Polyamine Analogue Antidiarrheals [PDF]
Journal of Medicinal Chemistry, 1996 The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
Fenglan Gao +8 more
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Spinally mediated opioid antidiarrheal effects
European Journal of Pharmacology, 1991To assess the role of opioid receptors in the spinal cord in regulation of functions of the intestinal mucosa in a secretory model, we evaluated the ability of i.t. administered mu (PL017), delta (DPDPE) and kappa (U50,488H) selective opioid agonists to inhibit diarrhea produced in mice by an injection of prostaglandin E2 (PGE2) (200 micrograms/mouse ...
Lemcke Pk, Thomas F. Burks, J E Shook
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Nigerian Geophagical Clay: A Traditional Antidiarrheal Pharmaceutical
Science, 1985The chief geophagical clay entering the West African market system comes from the village of Uzalla, Nigeria. Village inhabitants ascribe antidiarrheal properties to the clay, and they use it in traditional medicinal preparations to counteract intestinal problems.
Donald E. Vermeer, Ray E. Ferrell
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Experimental study of antidiarrheal activity of Salicairine®
Fundamental & Clinical Pharmacology, 1998Summary—Experimental antidiarrheal activity of a traditionally used medication, Salicairine®, was demonstrated in comparison to loperamide by significant inhibition of castor oil‐induced diarrhea in mice (increases in hard faeces/total faeces ratio of 38 and 54 and 5 and 54% with respect to controls, at 0.5 and 1 mL/kg and 1 and 2 mg/kg, respectively ...
T. Sevenet +4 more
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Toxicological, Antidiarrheal and Spasmolytic Activities of Solanum paniculatum
Planta Medica, 2015Solanum paniculatum is popularly known as "jurubeba-verdadeira". In folk medicine, its roots, stems, and leaves are used as tonics, anti-inflammatories, carminatives, diuretics, and for gastrointestinal disorders. This species is listed in the Brazilian Pharmacopoeia and belongs to the "Relação Nacional de Plantas Medicinais de Interesse ao SUS". Based
Hilzeth de Luna Freire Pessôa +10 more
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