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Rare Metastasis of Prostate Cancer in a Man With Ulcerative Colitis After Creation of an Ileal Pouch. [PDF]

open access: yesACG Case Rep J
Zemanek M   +5 more
europepmc   +1 more source
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Metabolically Programmed Polyamine Analogue Antidiarrheals

Journal of Medicinal Chemistry, 1996
The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
R J, Bergeron   +8 more
openaire   +3 more sources

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