Results 211 to 220 of about 3,155 (230)
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Demonstration of Antidiarrheal and Antimotility Effects of Wood Creosote
Pharmacology, 1993Wood creosote administered to rats prevented castor-oil-induced diarrhea with an ED50 of 53 mg/kg p.o. This antidiarrheal effect was apparently produced by acceleration of net fluid absorption from the intestine, as shown by a 52% decrease (p < 0.001) of residual fluid volume in an intestinal loop, and partly by suppression of intestinal motility. Wood
Takashi Shibata +2 more
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Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat
The Journal of Clinical Pharmacology, 1981Abstract: Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose‐dependent inhibition of diarrhea induced by castor oil treatment in the rat. Both drugs were more potent and longer acting than diphenoxylate. Pre‐ and posttreatment with naloxone (5 mg/kg) failed to prevent or antagonize the antidiarrheal effect of clonidine ...
Richard C. Ursillo +2 more
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Dependence liability of two antidiarrheals, nufenoxole and loperamide
Clinical Pharmacology and Therapeutics, 1980We compared the dependence liabilities of therapeutic doses of nufenoxole and loperamide. Ten subjects received 10 mg nufenoxole every 12 hr for 10 days, and 9 others received 4 mg loperamide every 12 hr for 10 days. On the eighth day of drug a sensitive single-blind intravenous naloxone challenge was used to assess dependence liability. After 0.2, 0.4,
Andrew Korey +2 more
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Antidiarrheal Agent Poisoning in a Child
JAMA: The Journal of the American Medical Association, 1965To the Editor:— The new antidiarrhea drug, diphenoxylate hydrochloride with atropine (Lomotil), is readily available. We should recognize that this compound may cause poisoning when taken in slightly excessive doses. A 2-year-old white boy ingested eight diphenoxylate tablets.
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Antidiarrheal Agents in the Treatment of Acute Diarrhea in Children
JAMA: The Journal of the American Medical Association, 1976To evaluate the efficacy of antidiarrheal agents in the treatment of diarrheal illnesses, a study was conducted with children in Guatemala who had an acute diarrheal illness. Eighty patients, aged 3 to 11 years, were hospitalized and treated for two days with one of five agents: kaolin-pectin suspension concentrate (Kao-Con), kaolin suspension, pectin ...
Jorge T. Rodriguez +4 more
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Pharmacology of Antidiarrheal Drugs
Annual Review of Pharmacology and Toxicology, 1983F. Awouters +2 more
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[Controlled clinical testing of an antidiarrheal].
MMW Fortschritte der Medizin, 2005To identify the efficacy and tolerance of activated charcoal in acute, nonspecific diarrhea.Randomized, double-blind study on 100 adults with nonspecific diarrhea, performed in two general practices. 94 were included in the final analysis, 6 patients - all from the placebo group abandoned treatment because of the absence of an effect.The major outcome ...
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Effect of antidiarrheal and antimotility drugs on ileal excreta
The American Journal of Digestive Diseases, 1977Commonly used antimotility and antidiarrheal drugs were administered to six ileostomized subjects to determine whether their normal ileal excreta and that induced by prune juice could be altered. A total of 49 studies were performed, 21 with and 28 without prune juice.
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Development of New Antidiarrheal Medications
Journal of Clinical Gastroenterology, 1983Kiertisin Dharmsathaphorn +2 more
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