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Dietary Polyphenols-Gut Microbiota Interactions: Intervention Strategies and Metabolic Regulation for Intestinal Diseases. [PDF]
Li H +5 more
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Atypical Presentation of an Enterovesical Fistula in a Nonverbal Patient With Recurrent Seizures and Diarrhea: A Case Report. [PDF]
Fatah F, Watson JT.
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Long-Term Toxicities of Immune Checkpoint Inhibitors. [PDF]
Abraham PE, Johnson DB.
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Rare Metastasis of Prostate Cancer in a Man With Ulcerative Colitis After Creation of an Ileal Pouch. [PDF]
Zemanek M +5 more
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Measuring What Matters: Patient-Reported Outcomes in Colon Cancer Care. [PDF]
Sokas CM, Ivatury SJ.
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Market Size in Innovation: Theory and Evidence from the Pharmaceutical Industry [PDF]
Daron Acemoglu, Joshua Linn
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Metabolically Programmed Polyamine Analogue Antidiarrheals
Journal of Medicinal Chemistry, 1996The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
R J, Bergeron +8 more
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