Results 221 to 230 of about 7,023 (269)

Pre- and Post-Operative Exercise and Nutrition Therapy in Patients with Esophageal Cancer Undergoing Esophagectomy: A Prospective Interventional Study.

Ann Nutr Metab
Ueno K, Nishigori T, Yoshida S, Hida K, Tsunoda S, Hosogi H, Hisamori S, Okamura R, Okumura S, Kanaya S, Kobayashi A, Nobori Y, Shide K, Yoshioka Y, Oshima Y, Goto Y, Goto K, Inagaki N, Matsuda S, Obama K.   +19 more
europepmc   +1 more source

Metabolically Programmed Polyamine Analogue Antidiarrheals [PDF]

Journal of Medicinal Chemistry, 1996
The design, synthesis, and testing of a novel class of antidiarrheal drugs based on a tetraamine pharmacophore are reported. While N1,N14-diethylhomospermine (DEHSPM) (5 mg/kg) completely prevents diarrhea in rodents, tissue distribution studies demonstrated that the principal metabolite of DEHSPM, homospermine (HSPM), accumulates and persists in ...
Fenglan Gao, Qianhong Wu, Guo Wei Yao, William R. Weimar, Raymond J. Bergeron, Hua Yao, Yang Feng, B.J. Raisler, Charles A. Sninsky   +8 more
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Dependence liability of two antidiarrheals, nufenoxole and loperamide

Clinical Pharmacology and Therapeutics, 1980
We compared the dependence liabilities of therapeutic doses of nufenoxole and loperamide. Ten subjects received 10 mg nufenoxole every 12 hr for 10 days, and 9 others received 4 mg loperamide every 12 hr for 10 days. On the eighth day of drug a sensitive single-blind intravenous naloxone challenge was used to assess dependence liability. After 0.2, 0.4,
Andrew Korey, D H Zilm, Edward M. Sellers   +2 more
openaire   +4 more sources

Interstitial lung disease and CDK4/6 inhibitors in the treatment of breast cancer

Expert Opinion on Drug Safety, 2023
Introduction CDK4/6 inhibitors have changed the treatment paradigm of many patients living with metastatic and early-stage high-risk hormone receptor (HR)-positive breast cancer.
I. Schlam, Antonio Giordano, S. Tolaney
semanticscholar   +1 more source

Antidiarrheal Effects of Dihydroergotamine

The Journal of Clinical Pharmacology, 1977
Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
Fuad Lechin, Bertha van der Dijs, Francisco Peña, Bentolila A   +3 more
openaire   +3 more sources

Antidiarrheal Drug Therapy [PDF]

Current Gastroenterology Reports, 2017
Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
openaire   +2 more sources

Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.

The Journal of Pharmacology and Experimental Therapeutics, 1979
Three synthetic antidiarrheals, diphenoxylate, loperamide and SC 27166, and two narcotics, morphine and codeine, were evaluated in rats by the intravenous and oral route for specificity and duration of their antidiarrheal, opiate-like and acute toxic effects.
C J, Niemegeers, J L, McGuire, J J, Heykants, P A, Janssen   +3 more
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MECHANISMS OF ANTIDIARRHEAL EFFECT BY PROBIOTICS

Journal of Pediatric Gastroenterology and Nutrition, 2016
Gastroenteritis is a major cause of morbidity and mortality worldwide. Several microbial pathogens cause secretory diarrhea such as Vibrio cholerae and enterotoxigenic Escherichia coli as well as enteric viruses such as Rotavirus (RV) and Norovirus and parasites including Cryptosporidium.
Eliana Ruberto, Alfredo Guarino, Vittoria Buccigrossi   +2 more
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Antidiarrheal therapy

Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
Richard N. Fedorak, Michael E. Field
openaire   +3 more sources

Spinally mediated opioid antidiarrheal effects

European Journal of Pharmacology, 1991
To assess the role of opioid receptors in the spinal cord in regulation of functions of the intestinal mucosa in a secretory model, we evaluated the ability of i.t. administered mu (PL017), delta (DPDPE) and kappa (U50,488H) selective opioid agonists to inhibit diarrhea produced in mice by an injection of prostaglandin E2 (PGE2) (200 micrograms/mouse ...
Lemcke Pk, Thomas F. Burks, J E Shook
openaire   +3 more sources