Results 221 to 230 of about 7,199 (273)
Some of the next articles are maybe not open access.
Polyamine Analogue Antidiarrheals: A Structure−Activity Study
Journal of Medicinal Chemistry, 2000The syntheses of a group of spermine polyamine analogues and their evaluation as antidiarrheals are described. Each compound was assessed in a rodent castor oil-induced diarrhea model for its ability to reduce stool output and weight loss in a dose-dependent manner. The spermine pharmacophore is shown to be an excellent platform from which to construct
R J, Bergeron +8 more
openaire +3 more sources
Interstitial lung disease and CDK4/6 inhibitors in the treatment of breast cancer
Expert Opinion on Drug Safety, 2023Introduction CDK4/6 inhibitors have changed the treatment paradigm of many patients living with metastatic and early-stage high-risk hormone receptor (HR)-positive breast cancer.
I. Schlam, Antonio Giordano, S. Tolaney
semanticscholar +1 more source
Antidiarrheal Effects of Dihydroergotamine
The Journal of Clinical Pharmacology, 1977Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone.
F, Lechin +3 more
openaire +2 more sources
Digestive Diseases and Sciences, 1987
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
openaire +2 more sources
Successful treatment of severe diarrhea has traditionally relied upon opiates or opiate derivatives. Recent advances in our understanding of intestinal fluid and electrolyte absorption have provided the opportunity to develop therapeutic agents specific for various points in the secretory and absorptive process.
R N, Fedorak, M, Field
openaire +2 more sources
Current Gastroenterology Reports, 2017
Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
openaire +2 more sources
Acute diarrhea often runs a self-limited course and little by way of treatment is needed except for oral rehydration therapy. Chronic diarrhea poses a longer-term problem. If not treatable with specific therapy aimed at the underlying pathophysiology, chronic diarrhea often needs long-term symptomatic therapy.This paper aims to examine the options for ...
openaire +2 more sources
Spinally mediated opioid antidiarrheal effects
European Journal of Pharmacology, 1991To assess the role of opioid receptors in the spinal cord in regulation of functions of the intestinal mucosa in a secretory model, we evaluated the ability of i.t. administered mu (PL017), delta (DPDPE) and kappa (U50,488H) selective opioid agonists to inhibit diarrhea produced in mice by an injection of prostaglandin E2 (PGE2) (200 micrograms/mouse ...
P K, Lemcke, J E, Shook, T F, Burks
openaire +2 more sources
Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.
The Journal of Pharmacology and Experimental Therapeutics, 1979Three synthetic antidiarrheals, diphenoxylate, loperamide and SC 27166, and two narcotics, morphine and codeine, were evaluated in rats by the intravenous and oral route for specificity and duration of their antidiarrheal, opiate-like and acute toxic effects.
C J, Niemegeers +3 more
openaire +2 more sources
Antimicrobial and Antidiarrheal drugs Survey
World Journal of Pharmaceutical Sciences, 2022Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose.
Suthar Mona +3 more
openaire +1 more source
Nigerian Geophagical Clay: A Traditional Antidiarrheal Pharmaceutical
Science, 1985The chief geophagical clay entering the West African market system comes from the village of Uzalla, Nigeria. Village inhabitants ascribe antidiarrheal properties to the clay, and they use it in traditional medicinal preparations to counteract intestinal problems.
D E, Vermeer, R E, Ferrell
openaire +2 more sources
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors
European Journal of Pharmacology, 1987Thiorphan and acetorphan, two potent inhibitors of enkephalinase (EC 3.4.24.11 membrane-metalloendopeptidase) significantly reduced the castor oil-induced diarrhea in rats when administered intravenously (or orally, for acetorphan) but not when administered intracerebroventricularly. These effects were more marked during the 90 min period following the
H, Marçais-Collado +4 more
openaire +2 more sources