Results 231 to 240 of about 7,023 (269)

Nigerian Geophagical Clay: A Traditional Antidiarrheal Pharmaceutical

Science, 1985
The chief geophagical clay entering the West African market system comes from the village of Uzalla, Nigeria. Village inhabitants ascribe antidiarrheal properties to the clay, and they use it in traditional medicinal preparations to counteract intestinal problems.
Donald E. Vermeer, Ray E. Ferrell
openaire   +3 more sources

Experimental study of antidiarrheal activity of Salicairine®

Fundamental & Clinical Pharmacology, 1998
Summary—Experimental antidiarrheal activity of a traditionally used medication, Salicairine®, was demonstrated in comparison to loperamide by significant inhibition of castor oil‐induced diarrhea in mice (increases in hard faeces/total faeces ratio of 38 and 54 and 5 and 54% with respect to controls, at 0.5 and 1 mL/kg and 1 and 2 mg/kg, respectively ...
T. Sevenet, Y. Brun, J. Willemot, Pierre Demenge, Xiu-Ping Wang   +4 more
openaire   +3 more sources

Demonstration of Antidiarrheal and Antimotility Effects of Wood Creosote

Pharmacology, 1993
Wood creosote administered to rats prevented castor-oil-induced diarrhea with an ED50 of 53 mg/kg p.o. This antidiarrheal effect was apparently produced by acceleration of net fluid absorption from the intestine, as shown by a 52% decrease (p < 0.001) of residual fluid volume in an intestinal loop, and partly by suppression of intestinal motility. Wood
Takashi Shibata, Norio Ogata, Tatsuya Baba   +2 more
openaire   +3 more sources

Toxicological, Antidiarrheal and Spasmolytic Activities of Solanum paniculatum

Planta Medica, 2015
Solanum paniculatum is popularly known as "jurubeba-verdadeira". In folk medicine, its roots, stems, and leaves are used as tonics, anti-inflammatories, carminatives, diuretics, and for gastrointestinal disorders. This species is listed in the Brazilian Pharmacopoeia and belongs to the "Relação Nacional de Plantas Medicinais de Interesse ao SUS". Based
Hilzeth de Luna Freire Pessôa, Anne Dayse Soares da Silva, Luiz Henrique César Vasconcelos, Natalia S. M. Ramos, Joedna Cavalcante Pereira, José Clementino-Neto, Fabiana A. de Cavalcante, Iara Leão Luna de Souza, Bagnólia Araújo da Silva, Tania M. S. Silva, Telma Maria Guedes da Silva   +10 more
openaire   +3 more sources

REVIEW: Racecadotril Versus Loperamide: Antidiarrheal Research Revisited

Digestive Diseases and Sciences, 2003
Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the literature and the models used was performed. Although pretreatment with high doses of racecadotril reduced cholera toxin-induced secretion and although ...
F. Awouters, S. Huijghebaert, G.N.J. Tytgat   +2 more
openaire   +3 more sources

Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat

The Journal of Clinical Pharmacology, 1981
Abstract: Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose‐dependent inhibition of diarrhea induced by castor oil treatment in the rat. Both drugs were more potent and longer acting than diphenoxylate. Pre‐ and posttreatment with naloxone (5 mg/kg) failed to prevent or antagonize the antidiarrheal effect of clonidine ...
Richard C. Ursillo, Harbans Lal, Gary T. Shearman   +2 more
openaire   +3 more sources

Antidiarrheal Agent Poisoning in a Child

JAMA: The Journal of the American Medical Association, 1965
To the Editor:— The new antidiarrhea drug, diphenoxylate hydrochloride with atropine (Lomotil), is readily available. We should recognize that this compound may cause poisoning when taken in slightly excessive doses. A 2-year-old white boy ingested eight diphenoxylate tablets.
openaire   +2 more sources

The pharmacology of SC-27166: a novel antidiarrheal agent.

The Journal of Pharmacology and Experimental Therapeutics, 1977
SC-27166 is the result of continuing efforts to discover selective and orally active antidiarrheal agents. SC-27166, which is chemically unrelated to opiates or neuroleptics, possesses potent constipating and antidiarrheal activity in several animal models. Tolerance to the constipating actions of SC-27166 did not develop in mice.
E Z, Dajani, R G, Bianchi, P F, East, J L, Bloss, G W, Adelstein, C H, Yen   +5 more
openaire   +2 more sources

Polyamine analogue antidiarrheals: a structure-activity study.

Journal of Medicinal Chemistry, 2001
R. Bergeron, J. Wiegand, J. McManis, W. Weimar, R. Smith, S. E. Algee, T. L. Fannin, M. Slusher, P. Snyder   +8 more
semanticscholar   +1 more source

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis.

Current pharmaceutical design, 2006
A. Verkman, G. Lukács, Luis J. V. Galietta   +2 more
semanticscholar   +1 more source