Rare but relevant: MDMA and hyponatraemia. [PDF]
AddictionAbstract Conventionally used for its stimulant, empathogenic and entactogenic effects, 3,4âmethylenedioxymethamphetamine (MDMA, ecstasy) is one of the most commonly used psychoactive drugs, specifically among young adults and in nightlife and recreational party contexts.
Garcia MR, Gomes NGM, Dias-da-Silva D.
europepmc +2 more sources
The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]
, 2014 Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A. +2 more
core +5 more sources
Anti-platelet therapy: ADP receptor antagonists. [PDF]
, 2011 The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S +3 more
core +1 more source
Utility and Safety of Tolvaptan in Cirrhotic Patients with Hyponatremia: a Prospective Cohort Study
Annals of Hepatology, 2017 Introduction and aim: Hyponatremia is common in patients with decompensated cirrhosis and is associated with increased mortality. Tolvaptan, a vasopressor V2 receptor antagonist, can increase free water excretion, but its efficacy and safety in cirrhotic
Ji-Dong Jia +16 more
doaj +1 more source
Biological and Pharmaceutical Bulletin, 2007 We investigated the effects of intravenous administration of conivaptan hydrochloride, a dual vasopressin V1A and V2 receptor antagonist, on blood electrolytes and plasma osmolality in rats with an experimental syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
Wada, Koh-ichi +6 more
openaire +3 more sources
The aquaretics in the treatment of hyponatremia
Italian Journal of Medicine, 2013 BACKGROUND Severe hyponatremia is the most common in-hospital electrolyte disorder and is a predictor of death among patients with chronic heart failure (CHF) and cirrhosis; it develops spontaneously or following diuretic therapy.
I. Portioli
doaj +1 more source
GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines [PDF]
, 2011 Breakthrough Breast CancerBackground: Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells.
Sims Andrew H +27 more
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Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor [PDF]
, 2008 Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
core +1 more source
Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists [PDF]
, 2015 The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth.
PALA, Daniele +16 more
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Molecular biological studies on neuropeptides of the adipokinetic hormone/red pigment-concentrating hormone family and the neuroparsin family in the arthropod sister groups of insects and crustaceans [PDF]
, 2012 Includes abstract.Includes bibliographical references.This study describes the identification of three novel precursor transcripts which includes the adipokinetic hormone (AKH) / red pigment-concentrating hormone (RPCH) and the neuroparsin (NP) from the ...
Anders, Lance
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