Results 41 to 50 of about 4,971 (132)

Tolvaptan for the treatment of the syndrome of inappropriate antidiuresis (SIAD) [PDF]

, 2023
The syndrome of inappropriate antidiuresis (SIAD), the commonest cause of hyponatraemia, is associated with significant morbidity and mortality. Tolvaptan, an oral vasopressin V2-receptor antagonist, leads through aquaresis to an increase in serum sodium
Baldeweg, SE, Bouloux, PM, Grossman, AB, Kaltsas, G, Tzoulis, P   +4 more
core  

Case report: Twice-daily tolvaptan dosing regimen in a challenging case of hyponatremia due to SIAD

Frontiers in Endocrinology
BackgroundSyndrome of inappropriate antidiuresis (SIAD) is one of the most frequent causes of euvolemic hyponatremia (serum sodium levels < 135 mEq/L) and it represents more than 35% of hyponatremia cases in hospitalized patients.
Anna Arecco, Davide Demontis, Leonardo Della Sala, Natale Musso, Stefano Gay, Mara Boschetti, Mara Boschetti, Diego Ferone, Diego Ferone, Federico Gatto   +9 more
doaj   +1 more source

Advancing antihypertensive drug development

British Journal of Pharmacology, EarlyView.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

Role of tolvaptan in the management of hyponatremia in patients with lung and other cancers: current data and future perspectives

Cancer Management and Research, 2016
Bijin Thajudeen,1 Abdulla K Salahudeen1,2 1Department of Nephrology, Banner University of Arizona Medical Center, 2Department of Nephrology, Southern Arizona Veterans Health Care System, Tucson, AZ, USA Abstract: Hyponatremia is the most frequently ...
Thajudeen B, Salahudeen AK
doaj  

Equivalent Efficacy and Decreased Rate of Overcorrection in Patients With Syndrome of Inappropriate Secretion of Antidiuretic Hormone Given Very Low-Dose Tolvaptan

Kidney Medicine, 2020
Rationale & Objective: Euvolemic hyponatremia often occurs due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Vasopressin 2 receptor antagonists may be used to treat SIADH.
Ramy M. Hanna, Juan Carlos Velez, Anjay Rastogi, Minhtri K. Nguyen, Mohammad K. Kamgar, Kyaw Moe, Farid Arman, Huma Hasnain, Niloofar Nobakht, Umut Selamet, Ira Kurtz   +10 more
doaj  

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model [PDF]

Maqboul A, Elsadek B. (2018) Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model. PeerJ 6:e4622 https://doi.org/10.7717/peerj.4622, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life. Here we aim to examine the expression profiles of transient receptor potential vanilloid 1 (TRPV1) and of transient receptor potential vanilloid 4 ...
arxiv   +1 more source

A randomised crossover trial of daridorexant for the treatment of chronic insomnia and nocturia

Journal of Sleep Research, EarlyView.
Summary This double‐blind, placebo‐controlled, two‐way crossover trial evaluated the efficacy and safety of daridorexant in patients with chronic insomnia and comorbid nocturia. In total, 60 patients aged ≥55 years with insomnia complaints for ≥3 months, Insomnia Severity Index (ISI) ≥13 and ≥3 voids/night for ≥1 month were randomised (1:1) to ...
Katharina Lederer, Heike Benes, Alan Fine, Sylvia Shoffner, Sandro Bacchelli, David Castro Diaz, Jose Emilio Batista, Racheal Rowles, Tobias Di Marco, Michael Meinel   +9 more
wiley   +1 more source

Prevalence, Risk Factors, and Short-term Consequences of Traumatic Brain Injury-associated Hyponatremia [PDF]

, 2015
Hyponatremia, a common electrolyte disorder associated with traumatic brain injuries (TBIs), has high mortality and morbidity rates. The aim of this study was to identify the risk factors for hyponatremia associated with TBI.
Ichiba, Shingo, Sato, Keiji, Ugawa, Toyomu, Ujike, Yoshihito, Yumoto, Tetsuya   +4 more
core   +1 more source

Association of Estimated Plasma Volume Status With Invasive Hemodynamics and All‐Cause Mortality in Patients With Liver Cirrhosis

JGH Open, Volume 9, Issue 6, June 2025.
ABSTRACT Background Estimated plasma volume status (ePVS) correlates with intravascular congestion and prognosis in patients with heart failure. The ePVS relationship with invasive hemodynamic profiling and clinical outcomes in patients with liver cirrhosis (LC) remains unclear. Methods This single‐center retrospective cohort study included LC patients
Esteban Kosak Lopez, Phuuwadith Wattanachayakul, Jose Manuel Martinez Manzano, Andrew Geller, Simone A. Jarrett, John Malin, Raul Leguizamon, Tara A. John, Rasha Khan, Ian McLaren, Alexander Prendergast, Kevin Bryan Lo, Zurab Azmaiparashvili   +12 more
wiley   +1 more source