Results 41 to 50 of about 145,432 (328)
Advanced Science, EarlyView.By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu +11 more
wiley +1 more source
Selectivity of Saflufenacil for Sweet Sorghum and Potential use of Na-Bentazon as a Safener [PDF]
Planta Daninha, 2015 The objective of this study was to assess the selectivity herbicide saflufenacil for two sweet sorghum hybrids, when sprayed in preemergence and postemergence, besides the use of Na-bentazon as a 'safener' for saflufenacil.
N.M. Correia, L.J.P. Gomes
doaj +1 more source
An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy
Advanced Science, EarlyView.This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo +11 more
wiley +1 more source
The botnet: webs of hegemony/zombies who publish [PDF]
, 2013 The scholarly communication structure at present bears a strong resemblance to a malware system called a botnet. This piece explores this metaphor and proposes ways in which the library can become a bi-directional information hub called the Research ...
Eve, Martin Paul
core +1 more source
Neck‐vein thrombosis during spaceflight
British Journal of Clinical Pharmacology, EarlyView.Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley +1 more source
Institutional democracy will strengthen our society, engaging citizenry and distributing power equitably [PDF]
, 2012 Mike O’Donnell argues that institutionalising people’s involvement in matters that affect their daily lives would surely act as an antidote to the apathy and disengagement that blights liberal democracy.
O'Donnell, Mike
core
2D pattern evolution constrained by complex network dynamics
, 2006 Complex networks have established themselves along the last years as being particularly suitable and flexible for representing and modeling several complex natural and human-made systems.
Carslaw H S +9 more
core +1 more source
British Educational Research Journal, EarlyView.Abstract By skipping school for their cause, young climate strikers repeatedly demonstrated their priorities in 2019 and 2020. They regularly chose to sacrifice a day of their formal education in favour of collective action. This study asks what we can learn from the reflections of former youth strikers.
Loz J. Hennessy
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban +7 more
wiley +1 more source
Medicina, 2022 Recently, it was demonstrated that copper complexes and 3,4-diaminopyridine can effectively reduce the activity of the botulinum neurotoxin light chain.
Harald Hefter, Sara Samadzadeh
doaj +1 more source