Nausea: Current knowledge of mechanisms, measurement and clinical impact [PDF]
Nausea is a subjective sensation, which often acts as a signal that emesis is imminent. It is a widespread problem that occurs as a clinical sign of disease or as an adverse effect of a drug therapy or surgical procedure.
Aapro+104 more
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Bimodal release ondansetron for acute gastroenteritis among adolescents and adults: A randomized clinical trial [PDF]
Importance: Vomiting resulting from acute gastroenteritis is commonly treated with intravenous antiemetics in acute care settings. If oral treatment were beneficial, patients might not need intravenous administered hydration or medication. Furthermore, a
Avarello, Jahn+11 more
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The impact of 5-hydroxytryptamine-receptor antagonists on chemotherapy treatment adherence, treatment delay, and nausea and vomiting. [PDF]
PurposeTo determine the incidence of chemotherapy-induced nausea/vomiting (CINV) and chemotherapy treatment delay and adherence among patients receiving palonosetron versus other 5-hydroxytryptamine receptor antagonist (5-HT3 RA) antiemetics.Materials ...
Grabner, Michael+3 more
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Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists [PDF]
PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its ...
A Fink-Jensen+153 more
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Genetic and Modifiable Risk Factors Contributing to Cisplatin-Induced Toxicities [PDF]
Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent that has potent antineoplastic activity due to its affinity for DNA and other ...
Dinh, Paul C. Jr.+4 more
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2023 Updated MASCC/ESMO Consensus Recommendations: prevention of radiotherapy-and chemoradiotherapy-induced nausea and vomiting [PDF]
Purpose Radiotherapy and chemoradiotherapy-induced nausea and vomiting (RINV and C-RINV) are common and distressing, and there is a need for guidance for clinicians to provide up to date optimal antiemetic prophylaxis and treatment.
Dennis, K.+5 more
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Cannabinoid Hyperemesis Syndrome [PDF]
Legalization of marijuana use will increase the number of people who will become long-term users. A prior medical record review study in Australia, in 2004, identified 19 chronic marijuana users who entered the emergency department with recurrent ...
Heise, Lynn
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Effects of Modification of Pain Protocol on Incidence of Post Operative Nausea and Vomiting. [PDF]
BackgroundA Perioperative Surgical Home (PSH) care model applies a standardized multidisciplinary approach to patient care using evidence-based medicine to modify and improve protocols.
Ahn, Kyle+7 more
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Metoclopramide Neurological Side Effects Screening; A Pharmacovigilence Study in Romanian Community Pharmacies [PDF]
Background. Metoclopramide is a pharmacological agent frequently used in therapy against nausea and vomiting that can occur in indigestion, motion sickness, gastric ulcer, pyloric spasm and after surgery as a side effect of some anesthetics.
Junghină, Adrian+4 more
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Economic evaluation of ondansetron: Preliminary analysis using clinical trial data prior to price setting [PDF]
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright © 1992 Macmillan Press Ltd.This study combines secondary analysis of efficacy and side-effect data from a randomised ...
Buxton, MJ, O'Brien, BJ
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