Results 31 to 40 of about 21,842 (260)

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

Prevention of Postoperative Nausea and Vomiting in Early Recovery: A Comparative Study of Ondansetron and Metoclopramide in Adults Undergoing Elective Lower Abdominal Surgery

AUIQ Complementary Biological System
Postoperative nausea and vomiting (PONV) remain common complications following surgery, despite the availability of various prophylactic antiemetic agents. This study aimed to compare the effectiveness of ondansetron and metoclopramide in preventing PONV
Majid Fakhir Al-Hamaidah , Ali Ihsan Abdul Mahdi , Maytham Alaa Shahid , Sajjad Salih Rasan , Lina M. Shaker , Shahab Abdulla, Ralela Makline   +6 more
doaj   +1 more source

New antiemetic drugs

, 1990
Three major areas of medicine are identified in which there is a need for new antiemetic drugs. These are the nausea and vomiting arising from gastrointestinal motility disturbances (functional dyspepsia, diabetic neuropathy, classical migraine), the ...
G. J. Sanger
core   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Outcomes of Patients with Aortic Diseases Treated by Antiemetic Drug, Who Were Transported by a Physician-staffed Helicopter in Japan

Journal of Emergencies, Trauma and Shock
Introduction: Aortic diseases have been observed to manifest the symptoms such as nausea and vomiting. We conducted a retrospective investigation to ascertain the clinical significance of antiemetic drug use for patients with aortic diseases transported ...
Youichi Yanagawa, Hiroki Nagasawa, Chihiro Maekawa, Noriko Tanaka, Michika Hamada, Soichiro Ota, Hiromichi Ohsaka, Kazuhiko Omori   +7 more
doaj   +1 more source

Analysis of Dietary Intake during Consecutive-Day Chemotherapy for Bone and Soft-Tissue Sarcomas

Frontiers in Nutrition, 2018
BackgroundBone and soft tissue sarcomas are commonly treated with consecutive-day chemotherapy regimens consisting of multiple anticancer agents. Chemotherapy-induced nausea and vomiting (CINV) is a serious adverse effect of these regimens and may result
Yuta Hori, Yuta Hori, Akio Sakamoto, Takashi Goto, Syouji Ando, Manato Yamashita, Masayo Shimomura, Takuji Uemura   +7 more
doaj   +1 more source

Study of the Mechanism of Antiemetic Effect of Lavandula angustifolia Mill. Essential Oil Based on Ca2+/CaMKII/ERK1/2 Pathway

, 2022
Jia Li,1,* Xiao Wang,1,* Shining Xun,2,* Qiuting Guo,3 Yao Wang,1 Yanzuo Jia,1 Wenfei Wang,1 Yujiao Wang,1 Taotao Li,1 Tiantian Tang,1 Junbo Zou,1 Mei Wang,1 Ming Yang,4 Fang Wang,4 Xiaofei Zhang,1,4 Changli Wang1 1Department of Pharmaceutics,
Zou J, Li J, Wang C, Yang M, Wang F, Xun S, Guo Q, Wang M, Li T, Zhang X, Jia Y, Wang W, Wang X, Tang T, Wang Y   +14 more
core  

Smoldering Systemic Mastocytosis Without Detectable KIT Mutation: A Debilitating Course and Therapeutic Challenge

Cancer Nexus, EarlyView.
Graphical abstract illustrating the clinical course and treatment response. ABSTRACT Systemic mastocytosis (SM) is a clonal hematologic neoplasm driven by activating KIT mutations, particularly D816V. Indolent SM typically follows a stable course, progression to higher‐burden subtypes is uncommon.
Homeniuk Anna, Medina Esenbekova, Micheal Bishara, Layo Akinrinwoye, Leila Metellus, Joane Titus   +5 more
wiley   +1 more source

The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review

European Psychiatry
Background Medication-induced dystonia (MID) is a movement disorder (MD), characterized by involuntary sustained or intermittent muscle contractions, causing abnormal, often repetitive, movements, postures, or both.
Kirsten Catthoor, Johan Detraux, Marc De Hert   +2 more
doaj   +1 more source

Antiemetic Principles of Alpinia officinarum

, 2016
Bioasay-guided fractionation of the antiemetic constituents of Alpinia officinarum was performed, and eight compounds (1−8) including a new compound were isolated. Among the seven known compounds, two flavonoids (1, 2), four diarylheptanoids (3, 5, 6, 8),
Kiyotaka Koyama (1562017), Daitetsu Shin (3061122), Kunio Takahashi (1562014), Kaoru Kinoshita (1562020)   +3 more
core   +1 more source