Results 131 to 140 of about 16,588 (280)

In Vivo Evaluation of Psoralen in a Copper Sulfate–Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5‐HT3A, and Muscarinic Receptors

ChemistryOpen, Volume 15, Issue 8, August 2026.
Psoralen (PSN) demonstrates significant dose‐dependent antiemetic activity in a copper sulfate–induced chick emesis model. Integrated in vivo and in silico analyses reveal reduced retching frequency, prolonged latency, and favorable multi‐receptor interactions with D2, 5‐HT3A, and muscarinic receptors, highlighting PSN as a promising multi‐target ...
Kishor Chandra, Sharif Uddin Bahar, Khadija Akter, Mst Muslima Khatun, Samiran Sadhukhan, Progna Saha Puja, Fazley Rohan, Md Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Faisal Alsenani, Salehin Sheikh, Muhammad Torequl Islam   +12 more
wiley   +1 more source

Targeting fibrosis in the treatment of lower urinary tract dysfunction

The Journal of Pathology, Volume 269, Issue 4-5, Page 493-503, August 2026.
Abstract Benign prostatic hyperplasia (BPH) is a widely prevalent age‐associated disease that is the main contributor to lower urinary tract dysfunction (LUTD) in aging men. Although prostate fibrosis has been recognized as a contributor to BPH pathophysiology, there are not any clinically available therapeutics that target this aspect of disease ...
Ajinkya R Limkar, Sophia M Vrba, Emily A Ricke, Zsuzsanna Fabry, Matthew S Lee, Kevin T McVary, William A Ricke   +6 more
wiley   +1 more source

Drug–Drug Interaction Signals for Major Bleeding in Nursing Home Residents: High‐Throughput Screening of Clopidogrel and Oral Anticoagulants

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 8, August 2026.
ABSTRACT Purpose Nursing home (NH) residents are at high risk for major bleeding and are frequently exposed to complex medication regimens that may increase the likelihood of clinically important drug–drug interactions (DDIs). However, DDI evidence from community‐dwelling populations may not generalize to NH residents, and real‐world signals involving ...
Adam M. D'Amico, Melissa R. Riester, Charles E. Leonard, Daniel A. Harris, Lori A. Daiello, Yu‐Chia (Sam) Hsu, Douglas P. Kiel, Meghan A. Cupp, Kaleen N. Hayes, Andrew R. Zullo   +9 more
wiley   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen, Asta Prescott, Caroline Folkersen, Jens Laigaard, Atena Saito, Caroline Lando Klammer, Mik Wetterslev, Emil Ipsen Ørskov, Mathilde Fahrendorff, Rebecca Kiær, Helene Holm Laigaard, Nichlas Hovmand, Lars Hyldborg Lundstrøm, Sebastian Buhl Rasmussen, Anders Kehlet Nørskov, Markus Harboe Olsen   +15 more
wiley   +1 more source

Granisetron Effectiveness on Postoperative Nausea and Vomiting and the Need for Rescue Antiemetics [PDF]

, 2006
An estimated 20-30% of all surgery patients experience postoperative nausea and vomiting. These percentages could affect more than one million patients every year.
Bolduc, Julie A.
core   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4592-4609, August 2026.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

Identification, reliability, and validity of drug–drug interaction checkers in chronic diseases: A systematic review

British Journal of Pharmacology, Volume 183, Issue 16, Page 4532-4561, August 2026.
Abstract Drug–drug interactions (DDIs) pose major risks in chronic disease management where polypharmacy is common. Although digital DDI tools are used widely to aid healthcare professionals, tools rely on theoretical interactions. This limitation questions their reliability and validity for clinical relevancy.
Brayden Ng Gibson, Sri Chodapuneedi, Huan Yee Koh, Sugandha Gupta, Danijela Gasevic, Anna Yuanyuan Wang, Catia Marzolini, Saye Khoo, Lorena Romero, Lachlan Dalli, Jack Janetzki, Harvey Jia Wei Koh, Stella Talic   +12 more
wiley   +1 more source

Intragastric Balloon Treatment Enhances Weight Maintenance Adjunct to Low‐Energy Diet and Group‐Based Cognitive Behavioural Therapy: A Randomized Controlled Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7300-7311, August 2026.
ABSTRACT Aims Low‐energy diet (LED) plus cognitive‐behavioural therapy (CBT) produces substantial short‐term weight loss in obesity, but long‐term maintenance remains difficult. We evaluated whether adding intragastric balloon (IGB) treatment to group‐based CBT improves weight maintenance after initial weight loss using LED.
Marije Galavazi, Qays Shahed, Hugo Hesser, Yang Cao, Stefan Jansson, Michiel van Nieuwenhoven, Johan Jendle   +6 more
wiley   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source