Compaction of fibrin clots reveals the antifibrinolytic effect of factor XIII [PDF]
Journal of Thrombosis and Haemostasis, 2016 Essentials Factor XIIIa inhibits fibrinolysis by forming fibrin-fibrin and fibrin-inhibitor cross-links. Conflicting studies about magnitude and mechanisms of inhibition have been reported.
Abdul, S. (Shiraazkhan) +4 more
exaly +16 more sources
Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study☆ [PDF]
European Journal of Cardio-thoracic Surgery, 2007 Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use.
Igor Rudez
exaly +2 more sources
Antifibrinolytic Role of a Bee Venom Serine Protease Inhibitor That Acts as a Plasmin Inhibitor [PDF]
PLoS ONE, 2012 Bee venom is a rich source of pharmacologically active substances. In this study, we identified a bumblebee (Bombus ignitus) venom Kunitz-type serine protease inhibitor (Bi-KTI) that acts as a plasmin inhibitor.
Hu Wan
exaly +2 more sources
The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; referees: 2 approved] [PDF]
Wellcome Open Research, 2018 Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.
Katharine Ker +7 more
doaj +8 more sources
The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 1; referees: 2 approved] [PDF]
Wellcome Open Research, 2017 Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.
Katharine Ker +7 more
doaj +2 more sources
Tranexamic Acid in Trauma Management: A Review of Evidence [PDF]
Journal of Acute Care Surgery, 2023 Hemorrhage is the leading cause of death in trauma patients and trauma induced coagulopathy (TIC) is a major contributor to bleeding mortality. TIC has a diverse pathophysiology triggered by injury and hypoperfusion, including platelet dysfunction ...
Namryeol Kim
doaj +1 more source
Effect of Local Tranexamic Acid on the Quality of Bone Healing in a Rat Spinal Fusion Model
Spine Surgery and Related Research, 2022 Introduction: The use of the antifibrinolytic agent tranexamic acid has positive effects on bleeding control, but our knowledge is still limited regarding how fibrinolysis suppression changes the process of bone formation and the quality of bone. Because
Ertugrul Sahin +5 more
doaj +1 more source
Effect of Intravenous Tranexamic Acid Administration on Blood Loss during and after Caesarean Delivery: A Randomised Controlled Study [PDF]
International Journal of Anatomy Radiology and Surgery, 2020 Introduction: India remains a major contributor to maternal deaths in the world. Haemorrhage after delivery (both vaginal & caesarean) is the leading cause. To reduce the haemorrhage, oxytocics are routinely used. In heavy bleeding, blood transfusion
Shyamali Dutta +2 more
doaj +1 more source
Gates Open Research, 2023 Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown of fibrin blood
Ian Roberts +7 more
doaj +1 more source
Comparative Study of Two Different Intravenous Doses of Tranexamic Acid with Placebo on Surgical Field Quality in Functional Endoscopic Sinus Surgery-A Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Intraoperative haemorrhage, which disrupts surgical patency, is a major obstacle for surgeons, especially in endoscopic sinus surgeries. Tranexamic acid is synthetic antifibrinolytic agent that binds competitively at lysine binding site on ...
Tamil Anbu Pannerselvam +2 more
doaj +1 more source