Compaction of fibrin clots reveals the antifibrinolytic effect of factor XIII: reply [PDF]
, 2016 Essentials Factor XIIIa inhibits fibrinolysis by forming fibrin-fibrin and fibrin-inhibitor cross-links. Conflicting studies about magnitude and mechanisms of inhibition have been reported.
D.C. Rijken +4 more
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The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; referees: 2 approved] [PDF]
Wellcome Open Research, 2018 Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.
Katharine Ker +7 more
doaj +8 more sources
Effect of Intravenous Tranexamic Acid Administration on Blood Loss during and after Caesarean Delivery: A Randomised Controlled Study [PDF]
International Journal of Anatomy Radiology and Surgery, 2020 Introduction: India remains a major contributor to maternal deaths in the world. Haemorrhage after delivery (both vaginal & caesarean) is the leading cause. To reduce the haemorrhage, oxytocics are routinely used. In heavy bleeding, blood transfusion
Shyamali Dutta +2 more
doaj +1 more source
Effect of Local Tranexamic Acid on the Quality of Bone Healing in a Rat Spinal Fusion Model
Spine Surgery and Related Research, 2022 Introduction: The use of the antifibrinolytic agent tranexamic acid has positive effects on bleeding control, but our knowledge is still limited regarding how fibrinolysis suppression changes the process of bone formation and the quality of bone. Because
Ertugrul Sahin +5 more
doaj +1 more source
Gates Open Research, 2023 Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown of fibrin blood
Ian Roberts +7 more
doaj +1 more source
Color vision disturbances secondary to oral tranexamic acid
Journal of the American College of Emergency Physicians Open, 2021 Tranexamic acid (TXA) is an antifibrinolytic commonly used to reduce blood loss due to surgical procedures, heavy menstruation, trauma, bleeding disorders, among other uses. Possible adverse reactions associated with TXA include abdominal pain, headache,
Adam S. Kiser +3 more
doaj +1 more source
Comparative Study of Two Different Intravenous Doses of Tranexamic Acid with Placebo on Surgical Field Quality in Functional Endoscopic Sinus Surgery-A Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: Intraoperative haemorrhage, which disrupts surgical patency, is a major obstacle for surgeons, especially in endoscopic sinus surgeries. Tranexamic acid is synthetic antifibrinolytic agent that binds competitively at lysine binding site on ...
Tamil Anbu Pannerselvam +2 more
doaj +1 more source
Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal
Periodontology 2000, EarlyView., 2023 Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra +3 more
wiley +1 more source
Tranexamic Acid; A Glittering Player in the Field of Trauma [PDF]
Bulletin of Emergency and Trauma, 2020 Trauma is still the leading cause of mortality and morbidity worldwide with an estimated 5.8 million mortalities every year [1] and approximately 60 million traumatic brain injuries (TBI) annually [2]. Hemorrhage remains the most common preventable cause
Fariborz Ghaffarpasand +4 more
doaj +1 more source
Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients [PDF]
, 2013 Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Herrmann, Eva +3 more
core +3 more sources