Results 21 to 30 of about 8,320 (205)

Color vision disturbances secondary to oral tranexamic acid

Journal of the American College of Emergency Physicians Open, 2021
Tranexamic acid (TXA) is an antifibrinolytic commonly used to reduce blood loss due to surgical procedures, heavy menstruation, trauma, bleeding disorders, among other uses. Possible adverse reactions associated with TXA include abdominal pain, headache,
Adam S. Kiser, Gena L. Cooper, Jonathan D. Napier, Gavin T. Howington   +3 more
doaj   +1 more source

Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis. [PDF]

PLoS ONE, 2015
Routine use of antifibrinolytic agents in spine surgery is still an issue of debate.To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA ...
Meng Wang, Xin-Feng Zheng, Lei-Sheng Jiang   +2 more
doaj   +1 more source

Efficacy and safety of using antifibrinolytic agents in spine surgery: a meta-analysis. [PDF]

PLoS ONE, 2013
PURPOSE: Spine surgery, particularly reconstructive surgery, can be associated with significant blood loss, and blood transfusion. Antifibrinolytic agents are used routinely to reduce bleeding in cardiac, orthopaedic, and hepatic surgery.
Chaoqun Yuan, Hailong Zhang, Shisheng He
doaj   +1 more source

Is Antifibrinolytic Therapy Effective for Preventing Hemorrhage in Patients with Hemophilia Undergoing Dental Extractions? A Systematic Review and Meta-Analysis

Clinical and Applied Thrombosis/Hemostasis, 2022
Objectives This systematic review aims to analyze the systemic administration of antifibrinolytics (tranexamic acid and aminocaproic acid) to prevent postoperative bleeding in patients with hemophilia.
Kaleem Ullah MBBS, Humza Mukhtar MBBS, Ushna Khalid MBBS, Zouina Sarfraz BSc, MBBS, Azza Sarfraz MBBS   +4 more
doaj   +1 more source

Tranexamic Acid; A Glittering Player in the Field of Trauma [PDF]

Bulletin of Emergency and Trauma, 2020
Trauma is still the leading cause of mortality and morbidity worldwide with an estimated 5.8 million mortalities every year [1] and approximately 60 million traumatic brain injuries (TBI) annually [2]. Hemorrhage remains the most common preventable cause
Fariborz Ghaffarpasand, Hamid Reza Abbasi, Shahram Paydar, Shahram Bolandparvaz, Maryam Dehghankhalili   +4 more
doaj   +1 more source

Aprotinin Inhibits Thrombin Generation by Inhibition of the Intrinsic Pathway, but is not a Direct Thrombin Inhibitor

TH Open, 2021
Background Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation.
Ton Lisman, Jelle Adelmeijer, Dana Huskens, Joost C. M. Meijers   +3 more
doaj   +1 more source

Efficacy of Tranexamic Acid Mesotherapy Using a Novel Device versus Topical Tranexamic Acid in Patients with Melasma: Protocol for a Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Melasma is a widely prevalent acquired condition characterised by gray-brown pigmentation with a predilection on the face, affecting the quality of life.
Yash Kashikar, Bhushan Madke, Adarshlata Singh, Soham Meghe, Kaveri Rusia   +4 more
doaj   +1 more source

Tranexamic acid for the prevention of postpartum bleeding in women with anaemia:  Statistical analysis plan for the WOMAN-2 trial: an international, randomised, placebo-controlled trial [version 2; peer review: 2 approved]

Gates Open Research, 2023
Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown of fibrin blood
Ian Roberts, Projestine Muganyizi, Oladapo Olayemi, Folasade Adenike Bello, Haleema Shakur-Still, Eni Balogun, Rizwana Chaudhri, Tim Collier   +7 more
doaj  

The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. [PDF]

PLoS ONE, 2015
Neonates undergoing open-heart surgery are particularly at risk of postoperative bleeding requiring blood transfusion. Aprotinin has attained high efficacy in reducing the requirement for a blood transfusion following a cardiopulmonary bypass, but is ...
Chih-Yuan Lin, Jeffery H Shuhaiber, Hugo Loyola, Hua Liu, Pedro Del Nido, James A DiNardo, Frank A Pigula   +6 more
doaj   +1 more source

Disseminated intravascular and intracardiac thrombosis after cardiopulmonary bypass

Journal of Anaesthesiology Clinical Pharmacology, 2017
Massive intracardiac and intravascular thrombosis is a rare complication following cardiopulmonary bypass (CPB). Most of the cases of the disseminated thrombosis have been reported in patients undergoing complex cardiac surgeries and those receiving ...
Deepak K Tempe, Parin Lalwani, Kapil Chaudhary, Harpreet S Minas, Akhlesh S Tomar   +4 more
doaj   +1 more source