Results 41 to 50 of about 14,357 (275)

Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]

, 2011
OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
core   +1 more source

Current research progress of tranexamic acid in the management of patients with traumatic injuries in emergency settings

Frontiers in Disaster and Emergency Medicine
IntroductionThe trauma is a leading cause of global mortality, with hemorrhage being a major contributor. Tranexamic acid (TXA), an antifibrinolytic agent, has shown promise in reducing blood loss and improving outcomes in trauma patients.
Gengwei Zhang, Juan Liu, Zhang Wen, Zhang Wen, Jia He, Haifeng Chang   +5 more
doaj   +1 more source

Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk [PDF]

, 2017
An enhanced thrombotic environment and premature atherosclerosis are key factors for the increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed secondary to interactions between platelets and coagulation proteins, is composed ...
A Agren, A Ceriello, A Hamsten, A Hamsten, A Lados-Krupa, A Liang, A Lutjens, A Rouch, A Rupin, A Sahebkar, A Tripodi, A Undas, A Undas, A Undas, AH Guimaraes, AH Henschen-Edman, AH Straten van, AS Wolberg, AS Wolberg, B Blomback, B Craen Van De, B Lipinski, B Rocca, B Wiman, B Zinman, BH Shieh, C Longstaff, CH Lundgren, CH Nair, CL Nikolajsen, CS Fox, D Capodanno, D Hill, D Leenaerts, D Ricklin, DA Gabriel, DA Lawrence, DA Lawrence, Darren Tomlinson, DJ Schneider, DL Crandall, DV Sakharov, E Angelantonio Di, E Chow, E Ernst, E Pretorius, E Pretorius, E Shacter, E Vercauteren, EG Levin, EJ Dunn, EJ Dunn, EL Hethershaw, EM Sherif, F Denorme, F Rollini, G Boden, G Gajos, G Jorneskog, GJ Brouwers, GK Hansson, GL Booth, GL Reed 3rd, GL Reed 3rd, H Elokdah, H Ritchie, HC Gerstein, HH Versteeg, HJ Beijers, HK Kim, I Juhan-Vague, I Shimomura, J Bester, J Danesh, J Montaner, J Svensson, J Weisel, JA Dormandy, JC Chapin, JD Mills, JG Dillinger, JH Foley, JL Ferreiro, JL Mega, JM Howes, JP Collet, JP Collet, JW Weisel, K Bangert, K Buelens, K Distelmaier, K Fatah, K Hess, K Hess, K Hess, K Leander, K Leander, Katherine Kearney, KE Brummel, Kerrie Smith, KN Lee, KN Lee, KN Lee, KN Lee, KN Lee, KR Machlus, L Badimon, L Ryden, L Wallentin, LM Belalcazar, M Konieczynska, M Pieters, M Pieters, M Pieters, M Rigla, M Udvardy, MA Bailey, MB Kahn, MC Alessi, ME Carr Jr, ME Meltzer, ME Meltzer, ME Meltzer, ME Stegenga, MG Marini, MR Hammer, MS Ardawi, N Gogitidze Joy, N Zheng, NH Tilburg van, NV Gorlatova, O Sigurdardottir, OJ Phung, P Chudy, P Clemmensen, P Katz, P Kohli, P Soma, P Soma, R Ajjan, R Favier, R King, RA Ajjan, RA Ajjan, RA Al-Horani, Ramzi Ajjan, RM Cubbon, RM Missov, RP Rother, RR Holman, S James, S Kimura, S Kimura, S Neergaard-Petersen, S Schulman, S Tehrani, S Tehrani, S Yener, SD Wiviott, SD Wiviott, SH Alzahrani, SH Alzahrani, SJ Cleland, SK Kunutsor, SL Carpenter, SP Marso, SR Fraser, ST Lord, T Koyama, T Kumada, T Lisman, T Plug, T Sasaki, T Tamaki, T Wyseure, T Wyseure, TC Holten van, TW Meade, U Amara, V Baeriswyl, VR Richardson, WB Kannel, X Zhou, X Zhou, Y Hori, Y Sakata, Y Sakata, Y Sakata, Y Sumi, Y Yano, YM Fortenberry, Z Valnickova   +191 more
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Understanding the influence of transfusion and blood loss on tranexamic acid concentration in scoliosis surgery with blood loss

British Journal of Clinical Pharmacology, EarlyView.
Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá, Luisa Barreiros, Marcela A. Segundo, Eugénia Cruz, Sibylle Langenecker   +4 more
wiley   +1 more source

The relationship between plasminogen activator inhibitor-1 levels and the course of disease in COVID-19 patients

Türk Biyokimya Dergisi, 2022
Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system.
Baltan Ecem, Serin Erdinç, Avci Burak Yasin, Akilli Işil Kibar, Çinar Ayşe Sürhan   +4 more
doaj   +1 more source

International Practice Variation in Post‐Tonsillectomy Hemorrhage: A Survey Study of Pediatric Otolaryngologists

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background A significant complication of pediatric tonsillectomy is post‐tonsillectomy bleeding (PTB). Management within and outside of the operating room (OR) is not standardized. We consolidated international similarities and differences in PTB management.
Gina M. Spencer, Claire A. Wilson, Jacob Davidson, Julie E. Strychowsky, Claire M. Lawlor, Hannah Burns, Eishaan K. Bhargava, James Fowler, M. Elise Graham   +8 more
wiley   +1 more source

Traumatic injury clinical trial evaluating tranexamic acid in children (TIC-TOC): study protocol for a pilot randomized controlled trial. [PDF]

, 2018
BACKGROUND: Trauma is the leading cause of morbidity and mortality in children in the United States. The antifibrinolytic drug tranexamic acid (TXA) improves survival in adults with traumatic hemorrhage, however, the drug has not been evaluated in a ...
Adelson, P David, Barnhard, Sarah E, Bobinski, Matthew, Ghetti, Simona, Hewes, Hilary A, Holmes, James F, Kuppermann, Nathan, Michael Dean, J, Myers, Sage R, Nishijima, Daniel K, Roberts, Ian, Schalick, Walton O, Stanley, Rachel M, TIC-TOC Collaborators of the Pediatric Emergency Care Applied Re, Tran, Nam K, Tzimenatos, Leah S, VanBuren, John   +16 more
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Comparative Study of Azelaic Acid Peeling vs. Tranexamic Acid Microneedling for the Treatment of Melasma

Dermato
Melasma is an acquired hyperpigmentation that is more common in women and mainly affects the face. It can significantly reduce quality of life due to its chronic nature and resistance to treatment.
Guilherme dos Anjos Camargo, Daniella Woinarovicz Menegheti, Leticia Simeoni Avais, Evelyn Assis de Andrade, Patrícia Mathias Döll Boscardin, Giovani Marino Favero   +5 more
doaj   +1 more source

Safety and Effectiveness of Uterine Gauze Packing for Refractory Postpartum Haemorrhage: A Systematic Review and Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The role of uterine gauze packing in treating refractory postpartum haemorrhage (PPH) is uncertain given limited evidence of benefit and possible harms. Objectives To evaluate the safety and effectiveness of uterine packing using plain gauze or gauze impregnated with haemostatic agent(s) for treating refractory PPH.
Maureen Makama, Alicia Ferguson, Mairead Connolly, Sarah Boudova, Samia Aziz, Lorena Romero, Joshua P. Vogel   +6 more
wiley   +1 more source

The impact of Cochrane Systematic Reviews : a mixed method evaluation of outputs from Cochrane Review Groups supported by the UK National Institute for Health Research [PDF]

, 2014
© 2014 Bunn et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Boaz, A Coffey, A Jorgensen, AM Moseley, C Ham, C Weiss, CE Estabrooks, CJ Cates, CJ Cates, CJ Cates, D Gillies, DL Sackett, E McInnes, European Medicines Agency, F Bunn, F Bunn, H Piwowar, HEFC, HT Martin, I Roberts, I Roberts, ID Cameron, J Burnett, J Comroe, J Grimshaw, J Grimshaw, J Lavis, J Lomas, J Ryan, JM Grimshaw, K Oliver, L Becker, L Thomas, LD Gillespie, LI Meho, M Buxton, M Dawes, M Gold, M Huberman, ME Falagas, N Black, O Olsen, P Lockhart, P Perel, P Perel, PA Sabatier, S Hanney, S Hanney, S Ismail, S Kuruvilla, S Kuruvilla, S Nutley, S Peckham, SE Cozzens, SR Hanney, TA Sheldon, TA Sheldon, TN van Leeuwen   +57 more
core   +2 more sources