TH Open, 2021 Background Aprotinin is a broad-acting serine protease inhibitor that has been clinically used to prevent blood loss during major surgical procedures including cardiac surgery and liver transplantation.
Ton Lisman +3 more
doaj +1 more source
Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects. [PDF]
, 2017 Intracerebral hemorrhages (ICH) represent about 10-15% of all strokes per year in the United States alone. Key variables influencing the long-term outcome after ICH are hematoma size and growth.
Lim-Hing, Krista, Rincon, Fred
core +2 more sources
The Efficacy of Antifibrinolytic Drugs in Children Undergoing Noncardiac Surgery
Anesthesia and Analgesia, 2014 David Faraoni, Susan M. Goobie
openalex +2 more sources
Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients [PDF]
, 2013 Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Herrmann, Eva +3 more
core +3 more sources
Antifibrinolytic drugs for treating primary postpartum haemorrhage.
Cochrane Database of Systematic Reviews, 2018 BACKGROUND Postpartum haemorrhage (PPH) - heaving bleeding within the first 24 hours after giving birth - is one of the main causes of death of women after childbirth. Antifibrinolytics, primarily tranexamic acid (TXA), have been shown to reduce bleeding
H. Shakur +5 more
semanticscholar +1 more source
Efficacy of Tranexamic Acid Mesotherapy Using a Novel Device versus Topical Tranexamic Acid in Patients with Melasma: Protocol for a Randomised Clinical Trial [PDF]
Journal of Clinical and Diagnostic ResearchIntroduction: Melasma is a widely prevalent acquired condition characterised by gray-brown pigmentation with a predilection on the face, affecting the quality of life.
Yash Kashikar +4 more
doaj +1 more source
40. The Benefits of Antifibrinolytic Administration in Minimally Invasive Craniosynostosis Repair [PDF]
Plastic and Reconstructive Surgery, Global OpenGabrielle C. Rodriguez, MD +8 more
doaj +2 more sources
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]
, 2011 OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
core +1 more source
Antifibrinolytic agents for reducing blood loss in scoliosis surgery in children.
Cochrane Database of Systematic Reviews, 2016 BACKGROUND This is an updated version of the original Cochrane review first published in 2008. Scoliosis surgery is often associated with substantial blood loss and potentially detrimental effects in children.
E. McNicol +4 more
semanticscholar +1 more source
Gates Open Research, 2023 Background: Postpartum haemorrhage (PPH) is responsible for over 50,000 maternal deaths every year. Most of these deaths are in low- and middle-income countries. Tranexamic acid (TXA) reduces bleeding by inhibiting the enzymatic breakdown of fibrin blood
Ian Roberts +7 more
doaj