Results 51 to 60 of about 8,320 (205)

A prospective non‐inferiority trial of pathogen reduced platelets compared to non‐pathogen reduced platelets for correction of viscoelastic platelet function testing in cardiac surgery

Transfusion, EarlyView.
Abstract Background Cardiac surgery on cardiopulmonary bypass (CPB) may alter platelet (PLT) function causing bleeding. The goal of this study is to evaluate the hemostatic effect of PRT‐PLTs compared to untreated PLTs stored in platelet additive solution (PAS) following transfusion in bleeding patients undergoing cardiac surgery on CPB.
Magali J. Fontaine, Jackline J. M. Lasola, Aidaelis Martinez‐Hernandez, Juliana N. Marshall, Soren Bentzen, Min Zhan, Parvez M. Lokhandwala, Kenichi Tanaka, Carlos H. Villa, Alexis Jones, Chintamani D. Atreya, Reney A. Henderson   +11 more
wiley   +1 more source

ANTIFIBRINOLYTIC ACTIVITY IN NORMAL PREGNANCY [PDF]

Journal of Clinical Pathology, 1960
It is found that serum antifibrinolytic activity is inhibitory both to the spontaneous fibrinolytic activity and to the activity of streptokinase-activated plasminogen.The titres of serum antiplasmin activity during gestation, labour, and the puerperium are all of the same order and do not differ from those in non-pregnant women. The marked decrease in
openaire   +3 more sources

Antifibrinolytic Therapy and Perioperative Considerations [PDF]

Anesthesiology, 2018
Abstract Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation. However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy, bleeding, and inflammatory responses. Antifibrinolytic agents are increasingly used to reduce bleeding, allogeneic blood administration, and adverse ...
Andreas Koster, Nigel S. Key, Jerrold H. Levy, Quintin J Quinones, Truman J. Milling   +4 more
openaire   +3 more sources

Forty‐eight‐hour cold‐stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures

Vox Sanguinis, Volume 120, Issue 3, Page 293-300, March 2025.
Abstract Background and Objectives Cold‐stored whole blood (CS‐WB) in paediatric cardiac surgery is making a resurgence, given its identified benefits compared to conventional blood component therapy (CT). Study Design and Methods A single‐centre retrospective study was conducted from January 2018 to October 2018 by including children <18 years of age ...
Amy L. Kiskaddon, Jennifer Andrews, Cassandra D. Josephson, Michael T. Kuntz, Dominique Tran, Jennifer Jones, Vyas Kartha, Nhue L. Do   +7 more
wiley   +1 more source

The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; referees: 2 approved]

Wellcome Open Research, 2018
Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.
Katharine Ker, David Prieto-Merino, Nikola Sprigg, Abda Mahmood, Philip Bath, Zhe Kang Law, Katie Flaherty, Ian Roberts   +7 more
doaj   +1 more source

Antifibrinolytics for heavy menstrual bleeding [PDF]

Cochrane Database of Systematic Reviews, 2018
Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase ...
Bryant-Smith, Alison C, Lethaby, Anne, Farquhar, Cynthia, Hickey, Martha   +3 more
openaire   +4 more sources

Treatment Landscape in Pediatric Immune Thrombocytopenia: Addressing Unmet Needs

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Pediatric immune thrombocytopenia (ITP) is associated with a multifaceted burden on children and their parents/caregivers due to bleeding, fatigue, activity restrictions, and psychological distress. Most children recover within 12 months, but up to 30% develop chronic ITP.
Joana Azevedo, Jennifer DiRaimo, Cindy Neunert, Nichola Cooper, Rachael F. Grace   +4 more
wiley   +1 more source

Spontaneous gastrocnemius muscle haematoma formation in a patient with alcoholic liver disease

The Pan African Medical Journal, 2020
Advanced liver disease is associated with several haemostatic alterations which can lead to either thrombosis or bleeding complications. Spontaneous muscle haematomas although a rare complication of liver cirrhosis is increasingly being described in the ...
Ndawapeka Tulonga Nhinda, Innocent Lule Segamwenge, Twitileni Nampweya, Chrizelda Engels   +3 more
doaj   +1 more source

A Bio‐Adaptive Janus‐Adhesive Dressing with Dynamic Lubrication Overlayer for Prevention of Postoperative Infection and Adhesion

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Slippery‐adhesive Janus gel dressing exhibits both stable tissue adhesive and outstanding efficiency in repelling physiological fluids. As a physical barrier, a liquid‐infused surface with a dynamic lubrication overlayer possesses excellent antibiofouling properties, making it highly effective in preventing bacterial infections and postoperative tissue
Yuan Gao, Junchang Guo, Shuangyang Li, Liansong Ye, Binyang Lu, Jiaxin Liu, Jing Luo, Yijia Zhu, Liuxiang Chen, Tingfa Peng, Jinlong Yang, Dehui Wang, Chaoming Xie, Xu Deng, Bing Hu   +14 more
wiley   +1 more source

Treatment of Bleeding Episodes With Efanesoctocog Alfa in Previously Treated Patients With Severe Hemophilia A in the Phase 3 XTEND‐1 Study

American Journal of Hematology, Volume 100, Issue 5, Page 813-820, May 2025.
ABSTRACT Despite therapeutic advances, people with hemophilia experience bleeds. These may be life‐threatening, result in permanent joint damage, chronic pain, difficulties with mobility/daily activities, and impact quality of life. In the XTEND‐1 study (NCT04161495), once‐weekly efanesoctocog alfa (50 IU/kg) prophylaxis provided highly effective bleed
Angela C. Weyand, Sandrine Meunier, Nobuaki Suzuki, Linda Bystrická, Graham Neill, Lydia Abad‐Franch, Annemieke Willemze, Alberto Tosetto   +7 more
wiley   +1 more source