Results 51 to 60 of about 14,357 (275)

Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. [PDF]

, 2006
Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established.
Looney, Mark R, Matthay, Michael A
core   +2 more sources

Bleeding Disorders in Children With Genetic Diseases: A Narrative Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol, Mariam Sbeity Barakat, Marjolaine Willems, Tasnime Akbaraly, Biron‐Andreani Christine, Isabelle Diaz, Alexandre Theron   +6 more
wiley   +1 more source

Current concepts of the management of dental extractions for patients taking warfarin [PDF]

, 2003
The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Background: Controversy has surrounded the correct management of patients therapeutically anticoagulated ...
Akbarian M., Albrechtsen OK, Askey JM, Behrmann SJ, Birn H., Bjoerlin G., Bjorlen G., Carter G., Carter GD, Carter GD, Cosgriff SW., Davis B., Davis FB, Declerk D., Duperon DF, Duvoison GE, Frank BW, Gersel-Pedersen N., Gonias SL, Greenberg MS, Heine RD., Hidaka N., Hirsh J., Kovacs B., Kwapsis B., Lytle BW, Marshall J., Marshall V., Matras H., Moody GH., Mulligan R., Okamoto S., Quick AJ., Ramstrom G., Rijken DC, Roller L., Shira RB, Sindet-Pedersen S., Sindet-Pedersen S., Sindet-Pedersen S., Tulloch J., Vinkier F., Walsh PN., Wepner F., Ziffer AM, Zusman S.   +45 more
core   +1 more source

Integration of Efanesoctocog Alfa in Clinical Practice for Children, Adolescents, and Young Adults With Severe Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa is a novel, “ultra‐extended half‐life” FVIII concentrate for bleed treatment and prevention in haemophilia A. Clinical trials excluded individuals with active or prior FVIII inhibitors, those on emicizumab, and previously untreated patients (PUPs).
Debbie Jiang, Natalie Johnston, Daniel Echelman, Stacy E. Croteau   +3 more
wiley   +1 more source

From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi‐Hydrogenation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
We present a new catalytic process that converts real‐life PET waste into ethyl 4‐hydroxymethylbenzoate (EHMB), which serves as a valuable intermediate for the synthesis of pharmaceuticals, an insecticide, and a novel polyester. Abstract We report here the upcycling of PET (polyethylene terephthalate) waste via semihydrogenation to make ethyl 4 ...
Pavel S. Kulyabin, James Luk, Evgeny A. Uslamin, Alexander A. Kolganov, Garima Saini, Raymundo Marcial‐Hernandez, Ketan Pancholi, Benjamin Kühne, Alexander Dauth, Aidan P. McKay, David B. Cordes, Evgeny A. Pidko, Amit Kumar   +12 more
wiley   +2 more sources

Enhancing the Evidence for Care in Underserved Bleeding Disorders Communities

Haemophilia, EarlyView.
ABSTRACT Background Major advances in haemophilia care have not translated equitably across all populations. Individuals with rare bleeding disorders (RBDs), people living in low‐ and lower‐middle‐income countries (LMICs) and women and girls with inherited bleeding disorders (WGWBD) continue to face significant diagnostic, therapeutic and research ...
Johnny Mahlangu
wiley   +1 more source

Impact of aprotinin and renal function on mortality: a retrospective single center analysis

Journal of Cardiothoracic Surgery, 2011
Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing
Von Visger Jon, O'Brien William, Abdel-Rasoul Mahmoud, Yu Lianbo, Gulati Parul, Schloss Brian, Awad Hamdy   +6 more
doaj   +1 more source

Applying the Canadian Head CT Criteria to Older Adults Seen in the Emergency Department After a Fall

Journal of the American Geriatrics Society, EarlyView.
Prevalence of intracranial bleeding in adults based on the CCTHR criteria. ABSTRACT Background The Canadian CT Head Rule (CCTHR) is validated in adults who hit their head and experience loss of consciousness, amnesia, or disorientation. There is less evidence to guide brain imaging when the fall history is unclear.
Geoff Kerr, Allie Chown, Mathew Mercuri, Natasha Clayton, Éric Mercier, Judy Morris, Rebecca Jeanmonod, Debra Eagles, Catherine Varner, David Barbic, Sameer Parpia, Ian M. Buchanan, Mariyam Ali, Yoan K. Kagoma, Ashkan Shoamanesh, Paul Engels, Sunjay Sharma, Andrew Worster, Shelley McLeod, Marcel Émond, Ian Stiell, Alexandra Papaioannou, Kerstin de Wit   +22 more
wiley   +1 more source

Integration of clinical parameters, genotype and epistaxis severity score to guide treatment for hereditary hemorrhagic telangiectasia associated bleeding

Orphanet Journal of Rare Diseases, 2020
Background Hereditary Hemorrhagic Telangiectasia (HHT) is a rare inherited disorder characterized by development of mucocutaneous telangiectases and visceral organ arteriovenous malformations, which can lead to recurrent, spontaneous bleeding and ...
Joan D. Beckman, Quefeng Li, Samuel T. Hester, Ofri Leitner, Karen L. Smith, Raj S. Kasthuri   +5 more
doaj   +1 more source

Development and validation of a pediatric transfusion medicine education assessment tool

Transfusion, EarlyView.
Abstract Background Pediatric transfusion medicine presents unique challenges due to differences in pediatric physiology and pathology compared to adults. Research shows that pediatric healthcare professionals have knowledge gaps in transfusion medicine, contributing to suboptimal practice.
Ines Zuna, Yulia Lin, Richard Haspel, Catharine M. Walsh, Jeffrey N. Bone, Casey Kapitany, Lani Lieberman, Teresa Skelton   +7 more
wiley   +1 more source