Results 51 to 60 of about 6,662 (219)

Impact of aprotinin and renal function on mortality: a retrospective single center analysis

Journal of Cardiothoracic Surgery, 2011
Background An estimated up to 7% of high-risk cardiac surgery patients return to the operating room for bleeding. Aprotinin was used extensively as an antifibrinolytic agent in cardiac surgery patients for over 15 years and it showed efficacy in reducing
Von Visger Jon, O'Brien William, Abdel-Rasoul Mahmoud, Yu Lianbo, Gulati Parul, Schloss Brian, Awad Hamdy   +6 more
doaj   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened.
Lucia Rugeri, Yelena Fruchou, Caroline Brodbeck, Marianne Bastien, Amandine Lioux, Giulia Gouy, Marion Cortet, Gil Dubernard, Yesim Dargaud   +8 more
wiley   +1 more source

Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). [PDF]

, 2011
OBJECTIVE: To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury.
CRASH-2 Collaborators, Intracranial Bleeding Study
core   +1 more source

Postpartum hemorrhage: Findings of a global survey by the World Association of Trainees in Obstetrics and Gynecology (WATOG)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality globally. This global survey was conducted to identify any disparities in the causes, prevalence, treatment, and mortality burden of PPH, with the aim of proposing relevant recommendations to bridge these disparities and ultimately reduce the global maternal mortality ...
Akaninyene E. Ubom, Zahra Muslim, Jolly Beyeza‐Kashesya, Dietmar Schlembach, Zechariah J. Malel, Ferdousi Begum, Inês Nunes, Alison Wright, FIGO Childbirth and PPH Committee   +8 more
wiley   +1 more source

Evaluating Tranexamic Acid Dosing Strategies for Postpartum Hemorrhage: A Population Pharmacokinetic Approach in Pregnant Individuals

The Journal of Clinical Pharmacology, EarlyView.
Abstract Tranexamic acid (TXA) is used for the treatment and occasionally prevention of postpartum hemorrhage (PPH); however, questions still remain regarding dosing regimen optimization. This study evaluated TXA pharmacokinetic (PK) data from four clinical trials (NCT: 04274335, 03287336, 00872469, and 02797119) conducted in pregnant participants ...
Allison Dunn, Mina Felfeli, Sebastian M. Seifert, Sixtine Gilliot, Anne‐Sophie Ducloy‐Bouthors, Haleem Shakur‐Still, Amber Geer, Stanislas Grassin‐Delyle, Naomi L. Luban, Johannes N. van den Anker, Jogarao V. S. Gobburu, Ian Roberts, Homa K. Ahmadzia   +12 more
wiley   +1 more source

Antifibrinolytics in cardiac surgery

Annals of Cardiac Anaesthesia, 2013
Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended. Significant bleeding during cardiac surgery, enough to cause re-exploration and/or blood transfusion, increases morbidity and mortality.
openaire   +4 more sources

Bleeding related to disturbed fibrinolysis [PDF]

, 2016
The components and reactions of the fibrinolysis system are well understood. The pathway has fewer reactants and interactions than coagulation, but the generation of a complete quantitative model is complicated by the need to work at the solid‐liquid ...
Cawthern K.M., Colucci G., Dombret H., Goodpasture E.W., Janning M., Kashuk J.L., Kluft C., Lisman T., Longstaff C., Miura O., Oudijk E.J., Rick M.E., Rijken D.C.   +12 more
core   +1 more source

The use of ROTEM in Detection of Coagulopathy and Altered Hemostasis in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Patients undergoing Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are at risk of coagulopathy. This study aims to evaluate the potential role of rotational thromboelastometry (ROTEM) in detecting alterations in coagulation during and after CRS/HIPEC.
Abdullah Mashat, Kadhim Taqi, Marina Parapini, Julia Chen, Jacqueline Trudeau, Jason Wilson, Trevor D. Hamilton, Andrea J MacNeill   +7 more
wiley   +1 more source

Current concepts of the management of dental extractions for patients taking warfarin [PDF]

, 2003
The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Background: Controversy has surrounded the correct management of patients therapeutically anticoagulated ...
Akbarian M., Albrechtsen OK, Askey JM, Behrmann SJ, Birn H., Bjoerlin G., Bjorlen G., Carter G., Carter GD, Carter GD, Cosgriff SW., Davis B., Davis FB, Declerk D., Duperon DF, Duvoison GE, Frank BW, Gersel-Pedersen N., Gonias SL, Greenberg MS, Heine RD., Hidaka N., Hirsh J., Kovacs B., Kwapsis B., Lytle BW, Marshall J., Marshall V., Matras H., Moody GH., Mulligan R., Okamoto S., Quick AJ., Ramstrom G., Rijken DC, Roller L., Shira RB, Sindet-Pedersen S., Sindet-Pedersen S., Sindet-Pedersen S., Tulloch J., Vinkier F., Walsh PN., Wepner F., Ziffer AM, Zusman S.   +45 more
core   +1 more source