Results 61 to 70 of about 18,529 (289)

Antifibrinolytic drugs and perioperative hemostasis [PDF]

American Journal of Hematology, 1997
Although excessive bleeding is widely recognized as a common complication of cardiac surgery, the recent success of antifibrinolytic drugs as prophylactic hemostatic agents has received little attention outside the surgical literature. The etiology of the coagulopathy following cardiac surgery is clearly multifactorial; however, the success of ...
Charles S. Greenberg, Thomas F. Slaughter   +1 more
openaire   +3 more sources

Using antifibrinolytics to tackle neuroinflammation

Neural Regeneration Research, 2020
Plasmin is generally known as a promotor of inflammation. Recent advancement suggests that it has a complex role as immunity modulator. Pharmacological inhibition of plasmin production and activity has been proven to improve neurological outcomes in traumatic brain injury and subarachnoid hemorrhage, most probably by preventing re-bleeding.
Atsev, Stanimir, Tomov, Nikola Stefanov
openaire   +5 more sources

Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery [PDF]

, 2008
Objectives: In addition to blood-sparing effects, aprotinin may have cardioprotective and anti-inflammatory effects during cardiopulmonary bypass-assisted cardiac surgery.
Bert, C., Ceuppens, J., De Buck, F., Delforge, M., Kasran, A., Meyns, B., Sergeant, P., Van Duppen, V., Van Hemelrijck, J., Wouters, Patrick   +9 more
core   +2 more sources

In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy

Pharmaceutics, 2020
Antifibrinolytic site-specific pharmaco-laser therapy (SSPLT) is an experimental treatment modality for refractory port wine stains (PWS). Conceptually, antifibrinolytic drugs encapsulated in thermosensitive liposomes are delivered to thrombi that form ...
Mingjuan Li, M. Ingmar van Raath, Shervin Khakpour, Ahmet Seçilir, Bart C. Sliggers, Xuan Huang, Baoyue Ding, Gert Storm, René R. van der Hulst, Anton I.P.M. de Kroon, Michal Heger   +10 more
doaj   +1 more source

What women think about consent to research at the time of an obstetric emergency: a qualitative study of the views of a cohort of World Maternal Antifibrinolytic Trial participants

BJOG: an International Journal of Obstetrics and Gynaecology, 2018
The World Maternal Antifibrinolytic (WOMAN) Trial was the first in the UK to use the option of waiver of informed consent at the time of an obstetric emergency.
G. Houghton, C. Kingdon, M. Dower, H. Shakur-Still, Z. Alfirevic   +4 more
semanticscholar   +1 more source

The relationship between plasminogen activator inhibitor-1 levels and the course of disease in COVID-19 patients

Türk Biyokimya Dergisi, 2022
Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system.
Baltan Ecem, Serin Erdinç, Avci Burak Yasin, Akilli Işil Kibar, Çinar Ayşe Sürhan   +4 more
doaj   +1 more source

Management of dental extraction in patients with Haemophilia A and B: a report of 58 extractions [PDF]

, 2014
Objectives: Patients with inherited bleeding disorders are at high risk of bleeding following oral surgery and present challenges to the oral surgeons. Aim of this study was to report our experience in dental extraction in patients exhibiting Haemophilia
Peisker, Andre, Raschke, Gregor-Franziskus, Schultze Mosgau, Stefan   +2 more
core   +1 more source

The antifibrinolytic and anti‐inflammatory effects of multiple doses of oral tranexamic acid in total knee arthroplasty patients: a randomized controlled trial

Journal of Thrombosis and Haemostasis, 2018
Essentials Perioperative blood loss and inflammatory response can significantly affect recovery after surgery. We studied the effects of multiple‐dose oral tranexamic acid on blood loss and inflammatory response. A postoperative four‐dose regimen brought
Dong Wang, Ze-yu Luo, Ze-Ping Yu, L-X Liu, C. Chen, Wei-Kun Meng, Q. Yu, F. Pei, Zongke Zhou, Wei-Nan Zeng   +9 more
semanticscholar   +1 more source

Current research progress of tranexamic acid in the management of patients with traumatic injuries in emergency settings

Frontiers in Disaster and Emergency Medicine
IntroductionThe trauma is a leading cause of global mortality, with hemorrhage being a major contributor. Tranexamic acid (TXA), an antifibrinolytic agent, has shown promise in reducing blood loss and improving outcomes in trauma patients.
Gengwei Zhang, Juan Liu, Zhang Wen, Zhang Wen, Jia He, Haifeng Chang   +5 more
doaj   +1 more source

Tranexamic acid therapy in pediatric cardiac surgery:a single center study [PDF]

, 2012
Background: We conducted a retrospective study of cyanotic and acyanotic patients undergoing cardiopulmonary bypass to determine the effect of tranexamic acid on blood loss and blood products administered during the operation in pediatric cardiac surgery.
Cioffi S, Giordano R, MANNACIO, VITO ANTONIO, Mucerino M, PALMA, GAETANO, Palumbo S, Poli V, Russolillo V, VOSA, CARLO   +8 more
core   +1 more source