Results 61 to 70 of about 14,357 (275)

Bleeding related to disturbed fibrinolysis [PDF]

, 2016
The components and reactions of the fibrinolysis system are well understood. The pathway has fewer reactants and interactions than coagulation, but the generation of a complete quantitative model is complicated by the need to work at the solid‐liquid ...
Cawthern K.M., Colucci G., Dombret H., Goodpasture E.W., Janning M., Kashuk J.L., Kluft C., Lisman T., Longstaff C., Miura O., Oudijk E.J., Rick M.E., Rijken D.C.   +12 more
core   +1 more source

Amustaline/glutathione pathogen‐reduced red cell hemoglobin utilization in complex cardiac surgery: A post hoc analysis of the phase 3 ReCePI trial

Transfusion, EarlyView.
Abstract Background The ReCePI randomized, controlled trial compared amustaline/glutathione pathogen‐reduced (PR) and conventional red blood cell (RBC) transfusions in cardiac surgery. Study design and methods We performed a post‐hoc analysis of hemoglobin (Hb) utilization and safety outcomes.
Ian J. Welsby, Michael E. Sekela, Edward L. Snyder, James D. Gorham, John S. McNeil, Kathy Liu, Stanley Bentow, Thomas Gniadek, Laurence Corash, Nina Mufti, Richard J. Benjamin, for the ReCePI Study Group   +11 more
wiley   +1 more source

The use of fibrinogen concentrate for the management of trauma-related bleeding. A systematic review and meta-analysis [PDF]

, 2017
Haemorrhage following injury is associated with significant morbidity and mortality. The role of fibrinogen concentrate in trauma-induced coagulopathy has been the object of intense research in the last 10 years and has been systematically analysed in ...
Franchini, Massimo, Liumbruno, Giancarlo M., Marano, Giuseppe, Marietta, Marco, Mengoli, Carlo, Pupella, Simonetta, Vaglio, Stefania   +6 more
core   +1 more source

The use of fibrinolysis inhibitors in cardiac surgery with cardiopulmonary bypass (literature review)

Вестник анестезиологии и реаниматологии
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva, K. N. Khrapov, A. A. Khryapa, K. Yu. Kankova   +3 more
doaj   +1 more source

Tranexamic acid dosing in pediatric trauma: Dose simulation based on population pharmacokinetic modeling in adult trauma patients

Transfusion, EarlyView.
Abstract Background Trauma is the most common cause of death in children >1 year of age, with hemorrhage being the most common preventable cause of death after injury. Antifibrinolytics like tranexamic acid (TXA) are a key aspect of trauma management in children, but optimal dosing remains unknown.
Gideon Stitt, Kevin Downes, Athena Zuppa, Christine Leeper, Kevin Watt, Philip Spinella   +5 more
wiley   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Antifibrinolytics in cardiac surgery [PDF]

, 2022
Roman Hájek
openalex   +1 more source

Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. [PDF]

, 2017
BACKGROUND: Antifibrinolytics reduce death from bleeding in trauma and post-partum haemorrhage. We examined the effect of treatment delay on the effectiveness of antifibrinolytics.
Ageron, François-Xavier, Antifibrinolytic Trials Collaboration, Gayet-Ageron, Angèle, Ker, Katharine, Prieto-Merino, David, Roberts, Ian, Shakur, Haleema   +6 more
core   +1 more source

CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIntracerebral hemorrhage (ICH) is an acute neurological disorder with high mortality and no effective treatment. In addition to the initial bleeding event, rebleeding and hematoma expansion are associated with poor outcome in these patients. We
José A. Rodríguez, Tomás Sobrino, Esteban López‐Arias, Ana Ugarte, Juan A. Sánchez‐Arias, Alba Vieites‐Prado, Irene de Miguel, Julen Oyarzabal, José A. Páramo, Francisco Campos, Josune Orbe, José Castillo   +11 more
doaj   +1 more source

Needle of Death Thromboelastography Tracings in Severely Bleeding Trauma Patients: A Novel Predictor of Hemorrhagic Blood Failure and Futile Resuscitation?

Academic Emergency Medicine, EarlyView.
Connor M. Bunch, Mark M. Walsh, Ernest E. Moore, Hunter B. Moore, Peter K. Moore, Jeffrey L. Johnson, Samuel J. Thomas, Sarah S. Fox, Daniel F. Lewandowski, Joseph B. Miller   +9 more
wiley   +1 more source