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A Comparative Study of the Immune Modulating Properties of Antifibrinolytics in Cardiac Surgery
PurposeAntifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels.
J van Pelt
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Antifibrinolytics combined with aPCC are not routinely administered to patients with acquired hemophilia A due to increased thrombotic risk. This association normalizes clot stability, and improves the efficacy of therapy, but can increase the risk of ...
Samantha Pasca
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DESMOPRESSIN AND ANTIFIBRINOLYTICS
International Anesthesiology Clinics, 1990Desmopressin appears to be a safe and effective hemostatic agent for use during surgery in patients with mild to moderate hemophilia or von Willebrand disease. Uremic patients also benefit from substitution of desmopressin for cryoprecipitate to control bleeding. The highly variable response to desmopressin by individual patients with hemophilia or von
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Antifibrinolytics in women with menorrhagia
Thrombosis Research, 2011Heavy menstrual bleeding is associated with increased local fibrinolysis. Antifibrinolytic agents have been used in women with menorrhagia with and without bleeding disorders, and have been demonstrated to decrease menstrual blood flow approximately 50% and improve quality of life.
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Antifibrinolytics in Subarachnoid Hemorrhage
Archives of Neurology, 1987Few conditions evince potential for disaster or cure as vividly as subarachnoid hemorrhage. If the patient survives the initial bleeding intact or with minor deficits, clipping of the aneurysm virtually eliminates the risk of recurrence. However, before something definite can be done, the patient faces the risk of rebleeding and later that of vasospasm.
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The Antifibrinolytic Properties of Cimetidine
Scandinavian Journal of Gastroenterology, 1986The mucosal fibrinolytic activity was estimated in 24 patients with duodenal ulcer and in 11 patients with gastric ulcer. The fibrinolytic activity was estimated in biopsy specimens taken during gastroscopy. Specimens were taken in the corpus, in the antrum, and in the duodenal mucosa.
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Cimetidine—an Antifibrinolytic Agent?
Scandinavian Journal of Gastroenterology, 1983The mucosal fibrinolytic activity was estimated in 14 patients with duodenal ulcer before and after 4 weeks' treatment with cimetidine. A significant reduction in fibrinolytic activity in the corpus and antrum mucosa was found after treatment. In patients with healed ulcer after treatment, the activity was lower than in patients with unhealed ulcers ...
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Antithrombotics and Antifibrinolytics
2014Pediatric thromboembolic events are rare, but the incidence of thrombosis in children has dramatically increased over the last decade and appears to be an increasing problem in pediatric tertiary care hospitals. They usually occur as a complication of a primary disease or treatment.
Donald Berry, Sriya Gunawardena
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Antifibrinolytic Treatment in Subarachnoid Hemorrhage
New England Journal of Medicine, 1984We enrolled 479 patients with subarachnoid hemorrhage in a multicenter, randomized, double-blind, placebo-controlled trial to determine whether treatment with the antifibrinolytic agent tranexamic acid improves outcome by preventing rebleeding. At three months there was no statistical difference between the outcomes in the tranexamic acid group and the
Vermeulen, M. +9 more
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Pharmacological agents: antifibrinolytics and desmopressin
Best Practice & Research Clinical Anaesthesiology, 2010This article provides an overview of the scientific evidence regarding the efficacy and safety of antifibrinolytic agents and desmopressin to reduce surgical blood loss. The synthetic derivatives of lysine are the only antifibrinolytics available in clinical practice since the withdrawal of aprotinin.
Yves, Ozier, Lorenn, Bellamy
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