Results 181 to 190 of about 11,634,387 (360)

Synthesis of Six Natural Products Enabled by Selective Hydroxylation of Orcinaldehyde‐Like Substrates With an Enzyme Library

Angewandte Chemie, EarlyView.
Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez, Evan O. Romero, Jonathan C. Perkins, Diego N. Rojas, Maximilian S. Hrigora, Alison R. H. Narayan   +5 more
wiley   +2 more sources

In Vitro Antifungal Effect of Selected Essential Oils Against Clinical Isolates Causing Fungal Keratitis: A Preliminary Pharmacological Evaluation

Future Pharmacology
Background/Objectives: Fungal keratitis (FK) is a current challenge in ophthalmology due to its association with severe visual impairment and the limitations of current antifungal therapies.
Elijah Akegbe, Nuno Mesquita, Célia Cabral, Emília Pereira, Luís Fernandes, Anália do Carmo, Rui Tomé, Dolores Pinheiro, João Pinheiro-Costa, Andreia M. Rosa, Elisa J. Campos   +10 more
doaj   +1 more source

Stepwise design, synthesis, and in vitro antifungal screening of (Z)-substituted-propenoic acid derivatives with potent broad-spectrum antifungal activity [PDF]

, 2015
Mohammed A KhedrDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, EgyptAbstract: Fungal infections are a main reason for the high mortality rate worldwide.
Khedr MA
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Human Vγ9Vδ2 T cells exhibit antifungal activity against Aspergillus fumigatus and other filamentous fungi

Microbiology Spectrum
Invasive aspergillosis (IA) and mucormycosis are life-threatening diseases, especially among immunocompromised patients. Drug-resistant Aspergillus fumigatus strains have been isolated worldwide, which can pose a serious clinical problem.
Satoru Koga, Takahiro Takazono, Hodaka Namie, Daisuke Okuno, Yuya Ito, Nana Nakada, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Naoki Iwanaga, Masato Tashiro, Noriho Sakamoto, Akira Watanabe, Koichi Izumikawa, Katsunori Yanagihara, Yoshimasa Tanaka, Hiroshi Mukae   +16 more
doaj   +1 more source

Delay of Cucumber Senescence and Life‐Extending Capabilities on Caenorhabditis elegans With the Postharvest Application of Sorbitol and Methyl Salicylate

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Methyl salicylate and sorbitol were taken as coating agents. Caenorhabditis elegans was taken as an animal model. The coated agents were applied in C. elegans. The life span study in C. elegans proves the authenticity of MS and SL. MS and SL extended the post‐harvest life of cucumber for 14 days.
Chirayu H. Trivedi, Vajida Munshi, Kalpesh J. Mehta, Jitendriya Panigrahi   +3 more
wiley   +1 more source

Enzymes Degrading Fungal Cell Wall Components vs. Those Exhibiting Lactonase Activity as Participants of Antifungals

Sci
Recently, we found that combining various antimicrobial polypeptides (AMPs) with enzymes exhibiting lactonase activity results in an antifungal agent with significantly enhanced stability and antimicrobial action efficiency.
Maksim Domnin, Aysel Aslanli, Olga Senko, Nikolay Stepanov, Elena Efremenko   +4 more
doaj   +1 more source

Antioxidant and Antifungal activities of Padina Pavonica and Sargassum Vulgare from the Lebanese Mediterranean Coast [PDF]

, 2012
The aim of our investigation was to evaluate the antioxidant, the antifungal activities and the phenolic content of extracts from two brown algae Padina Pavonica and Sargassum Vulgare from the Lebanese coast.
Mawlawi Hiba, Asma : Chbani, Chbani Asma, Naja Khaled, Antifungal Antioxidant   +4 more
core  

How Competitive Is Myanmar's Rice Sector? A Comparison of Production Costs and Efficiency

Agribusiness, EarlyView.
ABSTRACT This paper analyzes the cost competitiveness of rice production in Myanmar by examining production costs, cost efficiency, and the potential effect of improving cost efficiency on the country's global competitiveness. To achieve this, we conduct a comparative analysis of production costs among major rice‐producing countries and estimate the ...
Nandar Aye Chan, Orkhan Sariyev, Mohammad Ariful Islam, Manfred Zeller   +3 more
wiley   +1 more source