Results 1 to 10 of about 4,025,807 (397)
Antifungal Drug Repurposing [PDF]
Antibiotics, 2020 Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim +7 more
doaj +5 more sources
Molecular mechanisms governing antifungal drug resistance. [PDF]
NPJ Antimicrob Resist, 2023 Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus genera.
Lee Y, Robbins N, Cowen LE.
europepmc +2 more sources
Antifungal Drug Resistance: An Emergent Health Threat. [PDF]
Biomedicines, 2023 Fungal infections, named mycosis, can cause severe invasive and systemic diseases that can even lead to death. In recent years, epidemiological data have recorded an increase in cases of severe fungal infections, caused mainly by a growing number of ...
Vitiello A +8 more
europepmc +2 more sources
Drug-Resistant Fungi: An Emerging Challenge Threatening Our Limited Antifungal Armamentarium
Antibiotics, 2020 The high clinical mortality and economic burden posed by invasive fungal infections (IFIs), along with significant agricultural crop loss caused by various fungal species, has resulted in the widespread use of antifungal agents.
Amir Arastehfar +8 more
doaj +2 more sources
Antifungal Drug Resistance [PDF]
Clinical Infectious Diseases, 2003 The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term ...
Juergen Loeffler, David A. Stevens
openalex +4 more sources
Revista do Instituto de Medicina Tropical de São Paulo, 1991 Paul H. JACOBS, Lexie NALL
doaj +5 more sources
Metabolites, 2020 We reviewed the licensed antifungal drugs and summarized their mechanisms of action, pharmacological profiles, and susceptibility to specific fungi. Approved antimycotics inhibit 1,3-β-d-glucan synthase, lanosterol 14-α-demethylase, protein, and deoxyribonucleic acid biosynthesis, or sequestrate ergosterol.
Jiří Houšť +2 more
openaire +4 more sources
Fungal Drug Response and Antimicrobial Resistance
Journal of Fungi, 2023 Antifungal resistance is a growing concern as it poses a significant threat to public health. Fungal infections are a significant cause of morbidity and mortality, especially in immunocompromised individuals.
Paloma Osset-Trénor +2 more
doaj +1 more source
Antifungal Drug Concentration Impacts the Spectrum of Adaptive Mutations in Candida albicans
Molecular biology and evolution, 2023 Invasive fungal infections are a leading global cause of human mortality. Only three major classes of antifungal drugs are widely used, and resistance to all three classes can arise rapidly.
R. Todd +6 more
semanticscholar +1 more source
Pharmacotherapy, 2023 Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections.
E. McCreary +9 more
semanticscholar +1 more source