Results 181 to 190 of about 3,938,965 (348)
Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex
Advanced Science, EarlyView.The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua +12 more
wiley +1 more source
Changing Self‐Assembly Through Degradation: Phenyl Vinyl Ketone Polymer Nanoparticles Under Light
Angewandte Chemie, EarlyView.Photodegradable nanoparticles with sphere, worm, and vesicle morphologies are created via PISA using photo responsive PVK and non‐responsive HPMA blocks. Under UV light, worms quickly transform into spheres, while spheres and vesicles retain their shapes despite chain scission. Degradation also tailors surface properties and enables controlled release,
M. A. Sachini N. Weerasinghe +3 more
wiley +2 more sources
Advanced Science, EarlyView.The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee +28 more
wiley +1 more source
Angewandte Chemie, EarlyView.Fluorine nuclear spins can be hyperpolarized in solution by Overhauser dynamic nuclear polarization from a paramagnetic agent like galvinoxyl. This hyperpolarization can be transferred by nuclear magnetic resonance (NMR) to nearby 13C, leading to 13C signal enhancements up to ∼100.
Maik Reinhard +7 more
wiley +2 more sources
Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine
Aggregate, EarlyView.Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang +7 more
wiley +1 more source
Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs
Angewandte Chemie, EarlyView.A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee +4 more
wiley +2 more sources
Counterpoint: Alternative Trial Designs for Antifungal Drugs—Time to Talk [PDF]
, 2001 John H. Powers
openalex +1 more source
Cellpose+, a Morphological Analysis Tool for Feature Extraction of Stained Cell Images
Advanced Intelligent Discovery, EarlyView.We introduce Cellpose plus, a morphological and geometrical analysis tool for feature extraction of stained cell images built over Cellpose, a state‐of‐the‐art cell segmentation framework. We also introduce a dataset of DAPI and FITC stained cells to which our new method is applied.
Israel A. Huaman +10 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Silver nanoparticles (AgNPs) synthesized using eco‐friendly green synthesis approaches exhibit remarkable antimicrobial activity and enhanced drug delivery potential. Polymer‐AgNPs conjugates further improve drug stability and targeted delivery, offering a multifunctional platform for biomedical applications.
Mukil Madhusudanan +6 more
wiley +1 more source