Results 11 to 20 of about 4,025,807 (397)
Antifungal drug resistance: an update
European Journal of Hospital Pharmacy: Science and Practice, 2022 The number of antifungal classes is small, and resistance is becoming a much more frequent problem. Much greater emphasis needs to be placed on susceptibility testing and antifungal stewardship.
D. Denning
semanticscholar +1 more source
Frontiers in Microbiology, 2020 Topical drug administration is frequently used for the treatment of vaginal candidiasis; however, most formulations using this route do not provide prolonged drug release.
Fernanda Walt Mendes da Silva de Bastiani +5 more
doaj +1 more source
Advanced Vesicular Systems for Antifungal Drug Delivery
AAPS PharmSciTech, 2022 Fungal infections are considered one of the most serious conditions as their occurrence has increased lately. Fungi like Candida, Fusarium, and Aspergillus species mostly affect immunocompromised patients as they are considered opportunistic pathogens ...
Shaimaa Mosallam +2 more
semanticscholar +1 more source
Antibiotics, 2021 Clinical isolates of Candida yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such ...
Anna Herman, Andrzej Przemysław Herman
doaj +1 more source
Epigenetic Regulation of Antifungal Drug Resistance
Journal of Fungi, 2022 In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
S. Patra +3 more
semanticscholar +1 more source
New Approaches for Cryptococcosis Treatment
Microorganisms, 2020 Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifungal pharmacological treatment is limited to amphotericin B, fluconazole and 5- flucytosine.
Cristina de Castro Spadari +3 more
doaj +1 more source
Advances in Antifungal Drug Development: An Up-To-Date Mini Review
Pharmaceuticals, 2021 The utility of clinically available antifungals is limited by their narrow spectrum of activity, high toxicity, and emerging resistance. Antifungal drug discovery has always been a challenging area, since fungi and their human host are eukaryotes, making
Ghada Bouz, M. Doležal
semanticscholar +1 more source
Journal of Fungi, 2023 Due to their eukaryotic heritage, the differences between a fungal pathogen’s molecular makeup and its human host are small. Therefore, the discovery and subsequent development of novel antifungal drugs are extremely challenging. Nevertheless, since the 1940s, researchers have successfully uncovered potent candidates from natural or synthetic sources ...
Vanreppelen, Giel +3 more
openaire +4 more sources
Internal medicine journal (Print), 2021 Antifungal agents can have complex dosing and the potential for drug interaction, both of which can lead to subtherapeutic antifungal drug concentrations and poorer clinical outcomes for patients with haematological malignancy and haemopoietic stem cell ...
M. Chau +8 more
semanticscholar +1 more source
Antibiotics, 2021 Isavuconazole (ISZ) is used in the treatment of aspergillosis and mucormycosis. The purpose of this study was to evaluate the therapeutic drug monitoring (TDM) of ISZ samples from a clinical setting performed at Statens Serum Institut. Materials/methods:
Malene Risum +5 more
doaj +1 more source