Results 21 to 30 of about 4,025,807 (397)

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond.

Chemical Reviews, 2020
Fungal infections are a major contributor to infectious disease-related deaths across the globe. Candida species are among the most common causes of invasive mycotic disease, with Candida albicans reigning as the leading cause of invasive candidiasis ...
Yunjin Lee, Emily Puumala, Nicole Robbins, L. Cowen   +3 more
semanticscholar   +1 more source

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
A Lupetti, A Viudes, C d'Enfert, CA Kumamoto, CJ Nobile, CJ Nobile, D Andes, D Shahinas, David Andes, E Mowat, EM Kojic, ET Burt, G Ramage, G Ramage, G Ramage, G Ramage, G Ramage, Gordon Ramage, J McCourtie, J Nett, J Trepel, JB Anderson, JC Young, JE Nett, Jeniel Nett, Jose L. Lopez-Ribot, JR Blankenship, JS Finkel, L Ostrosky-Zeichner, LE Cowen, LE Cowen, LE Cowen, LE Cowen, LE Cowen, Leah E. Cowen, LH Pearl, LS Wilson, M Taipale, MA Pfaller, MA Pfaller, MJ Seidler, ML Richard, MM McNeil, Nicole Robbins, P Perumal, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, P Uppuluri, PK Mukherjee, Priya Uppuluri, R Pallavi, Ranjith Rajendran, Robin Charles May, RS Shapiro, RS Shapiro, S Garcia-Sanchez, S Park, S Perea, SD Singh, SJ Lin, SL LaFayette, SM Noble, SV Balashov, SZ Usmani, TE Zaoutis, Y Kaneko, YS Kim, Z Odabasi   +69 more
core   +8 more sources

Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine

Antibiotics, 2022
Fungal infections have become a growing public health challenge due to the clinical transmission of pathogenic fungi. The currently available antifungal drugs leave very limited choices for clinical physicians to deal with such situation, not to mention ...
Hua Zhong, Lei Han, Ren-Yi Lu, Yan Wang
doaj   +1 more source

Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans

mBio, 2021
Candida albicans is a prevalent human fungal commensal and also a pathogen that causes life-threatening systemic infections. Treatment failures are frequent because few therapeutic antifungal drug classes are available and because drug resistance and ...
Feng Yang, V. Gritsenko, Yaniv Slor Futterman, Lu Gao, Cheng Zhen, Hui Lu, Yuan-Ying Jiang, J. Berman   +7 more
semanticscholar   +1 more source

Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review

Antibiotics, 2023
Fungal infections are becoming one of the main causes of morbidity and mortality in people with weakened immune systems. Mycoses are becoming more common, despite greater knowledge and better treatment methods, due to the regular emergence of resistance ...
Ali A. Rabaan, Tarek Sulaiman, Shamsah H. Al-Ahmed, Zainab A. Buhaliqah, Ali A. Buhaliqah, Buthina AlYuosof, Mubarak Alfaresi, Mona A. Al Fares, Sara Alwarthan, Mohammed S. Alkathlan, Reem S. Almaghrabi, Abdulmonem A. Abuzaid, Jaffar A. Altowaileb, Maha Al Ibrahim, Eman M. AlSalman, Fatimah Alsalman, Mohammad Alghounaim, Ahmed S. Bueid, Awad Al-Omari, Ranjan K. Mohapatra   +19 more
doaj   +1 more source

Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents

Antimicrobial Agents and Chemotherapy, 2022
Candida auris is an urgent antimicrobial resistance threat due to its global emergence, high mortality, and persistent transmissions. Nearly half of C.
S. Jacobs, Jonathan L. Jacobs, Emily K. Dennis, S. Taimur, M. Rana, D. Patel, M. Gitman, G. Patel, S. Schaefer, K. Iyer, Jang I. Moon, Victoria Adams, P. Lerner, T. Walsh, Y. Zhu, M. R. Anower, M. Vaidya, S. Chaturvedi, V. Chaturvedi   +18 more
semanticscholar   +1 more source

Repurposing non-antifungal drugs auranofin and pentamidine in combination as fungistatic antifungal agents against C. albicans

Frontiers in Cellular and Infection Microbiology, 2022
Fungal infection is a serious global health issue, causing approximately 1.5 million mortalities annually. However, clinically available anti-fungal drugs are limited, especially for multidrug-resistant fungal infections.
Jiaying Lin, Xueyi Xiao, Yijing Liang, Huimin Zhao, Yingxiao Yu, Peiyan Yuan, Sha Lu, Xin Ding   +7 more
doaj   +1 more source

Antifungal Drugs and Drug-Induced Liver Injury: A Real-World Study Leveraging the FDA Adverse Event Reporting System Database

Frontiers in Pharmacology, 2022
Aims: We aimed to estimate the risk of drug-induced liver injury (DILI) from various antifungal treatments with azoles and echinocandins causing in real-world practice. Methods: We performed disproportionality and Bayesian analyses based on data from the
Zhi-xuan Zhou, Xue-dong Yin, Yu Zhang, Qi-hui Shao, X. Mao, Wen-juan Hu, Yunfang Shen, Bin Zhao, Zhi-ling Li   +8 more
semanticscholar   +1 more source

Comparative Genome Sequence Analyses of Geographic Samples of Aspergillus fumigatus—Relevance for Amphotericin B Resistance

Microorganisms, 2020
Amphotericin B (AMB) is a major fungicidal polyene agent that has a broad spectrum of action against invasive fungal infections. AMB is typically used as the last-line drug against serious and life-threatening infections when other drugs have failed to ...
Yuying Fan, Yue Wang, Jianping Xu
doaj   +1 more source

Variability in antifungal and antiviral use in hospitalized children [PDF]

, 2017
We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S, Goldman, Jennifer L, Hersh, Adam L, Kronman, Matthew P, Lee, Brian R, Newland, Jason G, Ross, Rachael K   +6 more
core   +2 more sources